FEV1/FVC ratio - Wikipedia, the free encyclopedia

http://en.wikipedia.org/wiki/FEV1%_predicted

FEV1/FVC ratio
From Wikipedia, the free encyclopedia

(Redirected from FEV1% predicted) The FEV1/FVC ratio, also called Tiffeneau index, is a calculated ratio used in the diagnosis of obstructive and restrictive lung disease.[1][2] It represents the volume of air exhaled in the first second.[3] See the Wikipedia article on spirometry for the definitions of FEV1 and FVC. Normal values are approximately 80%.[4] Predicted normal values can be calculated online (http://www.dynamicmt.com/dataform3.html) and depend on age, sex, height, weight and ethnicity as well as the research study that they are based upon. A derived value of FEV1% is FEV1% predicted, which is defined as FEV1% of the patient divided by the average FEV1% in the population for any person of similar age, sex and body composition.

TLC

Total lung capacity: the volume in the lungs at maximal inflation

RV

Residual volume: the volume of air remaining in the lungs after a maximal exhalation

ERV

Expiratory reserve volume: the maximal volume of air that can be exhaled from the end-expiratory position

Disease states
In obstructive lung disease, the FEV1 is reduced due to an obstruction of air escaping from the lungs. Thus, the FEV1/FVC ratio will be reduced.[3] More specifically, the diagnosis of COPD is made when the FEV1/FVC ratio is less than 70%.[5] The Global Initiative for Obstructive Lung Disease (GOLD) criteria also require that values are after bronchodilator medication has been given to make the diagnosis. According to the European Respiratory Society (ERS) criteria, it is FEV1% predicted that defines when a patient has COPD--that is, when the patient's FEV1% is less than 88% of the predicted value for men, or less than 89% for women.[5]. In restrictive lung disease, the FEV1 and FVC are equally reduced due to fibrosis or other lung pathology (not obstructive pathology). Thus, the FEV1/FVC ratio should be approximately normal, or even increased due to an increased FEV1 value (because of the decreased compliance associated with the presence of fibrosis in some pathological conditions).[3]
IRV

Inspiratory reserve volume: the maximal volume that can be inhaled from the end-inspiratory level

IC

Inspiratory capacity: the sum of IRV and TV

IVC

Inspiratory vital capacity: the maximum volume of air inhaled from the point of maximum expiration

VC

Vital capacity: the volume equal to TLC RV

VT

Tidal volume: that volume of air moved into or out of the lungs during quiet breathing (VT indicates a subdivision of the lung; when tidal volume is precisely measured, as in gas exchange calculation, the symbol VT or VT is used.)

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FEV1/FVC ratio - Wikipedia, the free encyclopedia

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References
1. ^ Swanney MP, Ruppel G, Enright PL, et al (December 2008). "Using the lower limit of normal for the FEV1/FVC ratio reduces the misclassification of airway obstruction" (http://thorax.bmj.com /cgi/pmidlookup?view=long&pmid=18786983) . Thorax 63 (12): 104651. doi:10.1136/thx.2008.098483 (http://dx.doi.org /10.1136%2Fthx.2008.098483) . PMID 18786983 (https://www.ncbi.nlm.nih.gov/pubmed/18786983) . http://thorax.bmj.com/cgi/pmidlookup?view=long& pmid=18786983. 2. ^ Sahebjami H, Gartside PS (December 1996). "Pulmonary function in obese subjects with a normal FEV1/FVC ratio" (http://www.chestjournal.org /cgi/pmidlookup?view=long&pmid=8989055) . Chest 110 (6): 14259. doi:10.1378/chest.110.6.1425 (http://dx.doi.org/10.1378%2Fchest.110.6.1425) . PMID 8989055 (https://www.ncbi.nlm.nih.gov/pubmed /8989055) . http://www.chestjournal.org /cgi/pmidlookup?view=long&pmid=8989055. 3. ^ a b c http://www.gp-training.net/protocol/respiratory /copd/spirometry.htm 4. ^ "Forced Expiration" (http://oac.med.jhmi.edu /res_phys/Encyclopedia/ForcedExpiration /ForcedExpiration.HTML) . http://oac.med.jhmi.edu /res_phys/Encyclopedia/ForcedExpiration /ForcedExpiration.HTML. Retrieved 2009-04-21. 5. ^ a b Nathell, L.; Nathell, M.; Malmberg, P.; Larsson, K. (2007). "COPD diagnosis related to different guidelines and spirometry techniques" (http://www.pubmedcentral.nih.gov /articlerender.fcgi?tool=pmcentrez&artid=2217523) . Respiratory research 8 (1): 89. doi:10.1186/1465-9921-8-89 (http://dx.doi.org /10.1186%2F1465-9921-8-89) . PMC 2217523 (https://www.ncbi.nlm.nih.gov/pmc/articles /PMC2217523/?tool=pmcentrez) . PMID 18053200 (https://www.ncbi.nlm.nih.gov/pubmed/18053200) . http://www.pubmedcentral.nih.gov /articlerender.fcgi?tool=pmcentrez&artid=2217523. [1] (http://respiratory-research.com/content/8/1/89)

FRC

Functional residual capacity: the volume in the lungs at the end-expiratory position

RV/TLC% Residual volume expressed as percent of TLC VA VL Alveolar gas volume Actual volume of the lung including the volume of the conducting airway. FVC Forced vital capacity: the determination of the vital capacity from a maximally forced expiratory effort FEV1 Volume that has been exhaled at the end of the first second of forced expiration FEF x Forced expiratory flow related to some portion of the FVC curve; modifiers refer to amount of FVC already exhaled FEF max The maximum instantaneous flow achieved during a FVC maneuver FIF Forced inspiratory flow: (Specific measurement of the forced inspiratory curve is denoted by nomenclature analogous to that for the forced expiratory curve. For example, maximum inspiratory flow is denoted FIFmax. Unless otherwise specified, volume qualifiers indicate the volume inspired from RV at the point of measurement.) PEF The highest forced expiratory flow measured with a peak flow meter MVV Maximal voluntary ventilation: volume of air expired in a specified period during repetitive maximal effort

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