Scheme of Study for M. Tech.

(5 year Integrated) Industrial Biotechnology for students admitted from 2007-08 VIII Semester: CODE MIBCBT801R01 MIBDBT804 MIBDBT805 MIBDBT806 MIBDBT807 MIBDBT808 MIBDBT809 MIBDBT810 MIBDBT811 MIBDBT812 MIBDBT813 COURSE Particle Mechanics & Mechanical Operations Biotechnology in Environmental Processes CAD of Process Equipment Basic Bioinformatics Biohydrometallurgy Products of Primary Metabolism Products of Secondary Metabolism Advanced Biochemistry Biotransformations Product Quality Management Transport phenomena (Students to choose any five from the above courses) Downstream Processing Laboratory II Basic Bioinformatics Laboratory Seminar Total L-T-P-C 3-1-0-4 4-0-0-4 3-1-0-4 3-1-0-4 4-0-0-4 4-0-0-4 4-0-0-4 3-1-0-4 4-0-0-4 4-0-0-4 4-0-0-4

MIBCBT802R01 MIBCBT803R01 MIBCBT804R01

0-0-3-2 0-0-3-2 0-0-3-1 20/23-4/1-9-29

3-1-0-4 MIBCBT801R01: PARTICLE MECHANICS & MECHANICAL OPERATIONS UNIT- I 15 periods

Particulate solids: Particle shape, size; methods of particle size measurements; screen analysis; sampling. Screening equipments; effectiveness of screening; storage of solids; Angle of repose; angle of slide; pile volume calculation. UNIT- II 15 periods

Size reduction: Principles of comminution, energy and power requirements in comminution, laws of crushing; size reduction equipments; open and closed circuit operation. Classification: Terminal settling velocity; classification equipments; centrifugal classification cyclones, hydro-clones Sedimentation, Batch and continuous; thickeners; Differential settling calculation. UNIT- III 15 periods

Filtration: Filter press and other batch filters; Rotary-drum filter and other continuous filters, filter media, filter aids, centrifugal filtration, filtration calculations. Flotation: Flotation equipments and reagents. UNIT- IV 15 periods

Mixing: Mixing of solids and pastes, mixers for pastes and dry powders, power requirements, mixer effectiveness, mixing index in blending granular solids. Agitation: Agitation and mixing of liquids, equipments, flow pattern and power consumption in agitated vessels, agitator design. TEXT BOOKS: 1. Unit Operations of Chemical Engineering, W. McCabe, J. C. Smith & P. Harriot, 7/e, McGraw-Hill, 2005. 2. Introduction to Chemical Engineering, Badger & Banchero, 1/e, Tata McGraw-Hill, 1997. REFERENCES: 1. Mechanical Operations for Chemical Engineering, 3/e, C. M. Narayanan & B. C. Bhattacharya, Khanna Publications, 2001. 2. Principles of Unit Operations, L. Foust & L. W. Wenzel, John Wiley, New York. 3. Chemical Engineering, J. M. Coulson & J. F. Richardson, vol. 2, 5/e, Asian Book Pvt. Ltd, 1998

4-0-0-4 MIBDBT804: BIOTECHNOLOGY IN ENVIRONMENTAL PROCESSES UNIT- I 12 periods

Biotechnology of solid waste treatment: Uncontrolled long-term bioconversion of garbage by deposition in sanitary landfills, controlled aerobic or anaerobic bioconversion of wastes, thermic treatment of wastes Technology and strategies of solid waste treatment: Factors influencing composting, composting systems, composting technologies: non-reactor systems, enclosed reactor systems, in-vessel reactor systems UNIT- II 12 periods

Microbiology of solid waste treatment: Introduction, heat production by microorganisms, phases of composting, compost pile as microbial habitat, microorganisms of composting, hygienic aspects of composting, pytopathogenic aspects of composting, mass and heat balances in composting UNIT- III 12 periods

Biological waste gas purification technology, performance parameters, process principles. Bioscrubbers: Design of activated sludge tank and absorption columns, special types of bioscrubbers Biofilters: Fundamentals and description of biofiltration, construction and procedure variants, sizing of biofilters Trickling filters: Construction and operation guidelines, strategies to avoid clogging, modeling of trickling filters Membrane procedures in biological waste gas purification, combination of membranes and microorganisms, membrane reactors UNIT- IV 12 periods

Industrial waste-water sources and treatment strategies: Waste water flow fractions from industrial plants, kinds and impact of wastewater components, production-integrated environmental protection, wastewater composition and treatment strategies in food processing industry UNIT- V 12 periods

Biofilms in bio-filtration: Introduction, extracellular polymeric substances, life in biofilms, biofilter microbial communities Bio-filtration processes for removal of organic matter: Methods of determination of biodegradable organic matter, effect of treatment processes on biodegradable organic matter, characterization of biofilters for BOM removal, effect of process parameters on efficiency of biofilters for BOM removal, modeling of biofilters Laws, statutory orders & directives on waste & waste-water treatment TEXTBOOK: Biotechnology, Volume 11, Environmental Processes, 2/e, H.-J. Rehm & G. Reed (Eds.), Wiley-VCH, Weinheim, 2001. REFERENCES: Environmental Biotechnology: Principles & Applications, B. E. Rittmann . P. L. McCarty, McGraw-Hill International, 2001. 3

3-1-0-4 MIBDBT805: CAD OF PROCESS EQUIPMENT UNIT I 12 periods

Properties Evaluation: Physical properties of liquids, gases & mixtures: density, viscosity, thermal conductivity, diffusivity, specific heat, latent heat, vapor pressure. Estimation of thermodynamic properties; liquid-phase activity coefficients; liquid-liquid equilibrium data. UNIT II Programs for the design of pipes & pumps, storage & pressure vessels. UNIT III 12 periods 12 periods

Programs for the design of shell-and-tube heat exchangers, condensers, single- & multipleeffect evaporators. UNIT IV 12 periods

Programs for the design of drying equipment like tray dryer, spray dryer, fluidized bed dryer. UNIT V Programs for the design of rotary-drum filter & centrifugal filter. Programs for the design of centrifuges, crystallizers & extractors. TEXTBOOK: Computer-Aided Design of Chemical Process Equipments, Bhattacharya & Narayanan, New Central Book Agency, 1992. Chemical Engineering, 3/e, R.K. Sinnott, J.M. Coulson & J.F. Richardson (Eds.), Vol. 6, Butterworth Heinemann, 2002. REFERENCES: Plant Design & Economics for Chemical Engineers, 5/e, Peter & Timmerhaus, McGrawHill, 2003. 12 periods

3-1-0-4 MIBDBT806: BASIC BIOINFORMATICS UNIT I 14 periods

Overview of bioinformatics: the scope of bioinformatics; bioinformatics & the internet; useful bioinformatics sites on the www. Data acquisition: sequencing DNA, RNA & proteins; determination of protein structure; gene & protein expression data; protein interaction data. Databases contents, structure & annotation: file formats; annotated sequence databases; miscellaneous databases. UNIT II 13 periods

Retrieval of biological data: data retrieval with Entrez & DBGET/LinkDB; data retrieval with SRS (sequence retrieval system). Searching sequence databases by sequence similarity criteria: sequence similarity searches; amino acid substitution matrices; database searches, FASTA & BLAST; sequence filters; iterative database searches & PSIBLAST. Multiple-sequence alignment, gene & protein families: multiple-sequence alignment & family relationships; protein families & pattern databases; protein domain families. UNIT III 10 periods

Phylogenetics, cladistics & ontology; building phylogenetic trees; evolution of macromolecular sequences. Sequence annotation: principles of genome annotation; annotation tools & resources. UNIT IV 12 periods

Structural bioinformatics: conceptual models of protein structure; the relationship of protein three-dimensional structure to protein function; the evolution of protein structure & function; obtaining, viewing & analyzing structural data; structural alignment; classification of proteins of known three-dimensional structure: CATH & SCOP; introduction to protein structure prediction; structure prediction by comparative modeling; secondary structure prediction; advanced protein structure prediction & prediction strategies. UNIT V 11 periods

Microarray data analysis: microarray data, analysis methods; microarray data, tools & resources; sequence sampling & SAGE. Bioinformatics in pharmaceutical industry: informatics & drug discovery; pharmainformatics resources. Basic principles of computing in bioinformatics: running computer software; computer operating systems; software downloading & installation; database management. TEXTBOOK Bioinformatics, D. R. Westhead, J. H. Parish & R. M. Twyman, Viva Books Private Limited, New Delhi, 2003.

4-0-0-4 MIBDBT807: BIOHYDROMETALLURGY UNIT I 12 periods

Introduction to hydrometallurgy- Construction of Eh-pH Diagrams. Different types of metallurgical processes- High Pressure- Precipitation- Solvent Extraction- Column Chromatography- Their limitations. Concept of Biohydrometallurgy-Definition-Different biohydrometallurgical processes-Bioleaching-Bioremediation-Bioaccumulation-Bioflotation and Bioflocculation- its Significance and Importance. Ores and Minerals- their definition and difference. Techniques of determination of Metal ion concentration in Minerals-ores. UNIT II 12 periods

Fundamentals and Principle of Bioleaching-Importance of Bioleaching- Mining Zones- Acid Mine Drainage [AMD]- Its features and Characteristics- Mechanism of Bioleaching- Direct and Indirect Methods- Galvanic Conversion- its role in Metal dissolution. Bioleaching technology Shake Flask- Column Leaching-In situ Leaching-Dump Leaching Heap Leaching-their significance and applications in biohydrometallurgy. Microbes in Bioleaching: Leptospirillum- Acidithiobacillus ferrooxidans-Acidithiobacillus thiooxidans- their isolation from AMD-Morphology. Culture Characteristics-AcidiophilicAtmospheric Carbon-di-oxide fixation-Nitrogen Fixation-Growth & Nutrition requirement. Properties of Microbes- pH, Different energy source (Fe2+; Reduced forms of Sulphur) and the mechanism of energy generation. Detection of Purity of Cultures- Solid Medium-SEM Images-Counting of Cells from Liquid Medium. Mixed Cultures- Role in Bioleaching. UNIT III 12 periods

Introduction to Mineral Processing-Scope & Importance. Basic Units of Operation. Definitions of Gangue-Concentrate-Tailing-Yield and Recovery Processess. Sulphide Minerals-their Relevance in Bioleaching of metals-Different Sulphide Minerals of metals used in bioleaching-their properties and characteristics. Refractory Sulphide Ores-Definition & Importance. Concentration of Minerals-Fundamentals of Flotation Method-reagents used and their importance. Characteristics of Minerals Evaluation of Mineral Properties Particle Size-Its features & Methods of Obtaining different average Particle Size-Ball Milling Technique. Determination of Particle Size-Laser Diffraction Method. Introduction to Particle Size separation processes-Role of Particle Size in Bioleaching. Pulp-density-Effect on Bioleaching of Sulphide Minerals. UNIT IV 12 periods

Commercial applications of biohydrometallurgy-Copper Extraction-By Insitu-Dump-Heap Leaching. Bioleaching of Uranium. Bioprocessing of Refractory Sulphidic Ores Concentrates-Flow Sheet for biotreatment & Cyanidiation of Gold-Biotechnological approach for Gold recovery by Biooxidation processes. Galvanic Interaction of metal Recovery Role of Redox Potentials in metal dissolution- Role of Acidophilic Organism in Galvanic Processes-Regeneration of Ferric ions- Maintenance of Oxidative environment. Introduction to Deep Sea Nodules-Their significance and Importance.

UNIT V

12 periods

Fundamentals and Mechanisms of bioremediation-biosorption and bioaccumulation processes. Impact of these processes on environmental ecology maintenance. Microbes involved in these systems-Fungi-Classification and Important members of this family involved in these process. Mechanism of biosorption of Chromium-Lead-Arsenic by exopolysaccharides of Fungi-bacteria and their relevance in pollution control. TEXTBOOKS Principles and Practice of Bioleaching, W.C. Cooper & D.B. Dreisigner (Eds.)., Vol 1-3., Elsevier Publications, 1995. Biohydrometallurgy and the Environment towards the Mining of 21st century, Part B., R.Amils., Ballester (Eds)., Elsevier Publications, 2001 Mineral Biotechnology: Microbial Aspects of Mineral Beneficiation, Metal Extraction and Environmental Control, S. Komar Kawatra., K.A. Natarajan (Eds.), Society for Mining Metallurgy and Exploration, 2004. REFERENCES: Biohydrometallurgy : Fundamentals, Technology and Sustainable Development: Part A, V.S.T. Ciminelli, O. Garcia. Jr (Eds.), Elsevier Publications, 2001. Microbes Minerals and Environment, K.A. Natarajan., 1/e, Geological Survey of India, 1998.

4-0-0-4 MIBDBT808: PRODUCTS OF PRIMARY METABOLISM UNIT I 12 periods

Sugar-based raw materials for fermentation applications: Provenance of sugar and raw materials, quality parameters for sugar, raw materials as substrates, molasses Starch-based raw materials for fermentation applications: Starch, Maltodextrins, Liquid Syrups, Dextrose, Sorbitol, Selection of starch-derived raw materials for fermentation UNIT II 14 periods

Production of Ethanol: Raw materials, technical amylolysis, starch degradation by autoamylolysis, mashing processes, fermentation, distillation Ethanol Potential source of energy and chemical products: Yeast fermentation, Ethanol fermentation with bacteria, Immobilized cell systems, substrates for production of industrial alcohol, industrial processes, by-products in ethanol fermentation, Ethanol as liquid fuel, potential markets for ethanol UNIT III 10 periods

Microbial production of glycerol and other polyols: Processes for glycerol production, recovery of glycerol, applications of glycerol Microbial production of acetone and isopropanol: Biochemistry and genetics of solventproducing clostridia, strain improvement, continuous culture, cell recycling, alternative substrates UNIT IV 12 periods

Microbial production of Lactic acid: Biology and Biochemistry of industrial Lactic Acid fermentation, production strains, industrial production including product quality Microbial production of Citric acid: Regulation of citric acid accumulation, production procedures, product recovery and purification, citric acid from other substances and organisms, process kinetics, utilization of citric acid UNIT V 12 periods

Microbial production of Gluconic acid: Fungal gluconate production, regulation of gluconate accumulation, industrial production procedures, product recovery and processing, utilization of gluconic acid and gluconates Production and use of amino acids: Market of amino acids, production of amino acids used in food, feed, pharmaceutical and cosmetic industries TEXTBOOK Biotechnology, Volume 6, Products of Primary Metabolism, 2/e, H.-J. Rehm & G. Reed (Eds.), Wiley-VCH, Weinheim, 2001.

4-0-0-4 MIBDBT809: PRODUCTS OF SECONDARY METABOLISM UNIT I 12 periods

General aspects of secondary metabolism: The importance of secondary metabolites as drugs, secondary metabolism an expression of cellular and organismic individuality, biosynthetic pathways, variability of structures of secondary metabolites, new products of secondary metabolism UNIT II 12 periods

Regulation of bacterial antibiotic production: Themes in the regulation of antibiotic production, regulation of antibiotic production in streptomycetes and their relatives, genetics of antibiotic production UNIT III 12 periods

Screening of novel receptor-active compounds of microbial origin: Assay methods for screening, receptor antagonists, receptor agonists, inhibitors of virus receptor binding gp120-CD4 binding inhibitors Microbial siderophores: Bacterial siderophores, fungal siderophores, transport mechanisms UNIT IV 12 periods

Lantibiotics: The unique chemistry and structure of lantibiotics, lantibiotic structures in solution, genes/proteins involved in lantibiotic biosynthesis and genetic regulation, biological activities of lantibiotics, applications of lantibiotics UNIT V 12 periods

Secondary products from plant cell cultures: Secondary product formation in suspension cell culture, products of commercial interest accumulating in traces, secondary product formation in hairy root cultures, plant tissue culture as new source for chemicals Biotechnological drugs as anti-tumor agents: Prescreening for antineoplastic agents, classical anticancer drugs, non-classical approaches to antitumor drugs TEXTBOOK Biotechnology, Volume 7, Products of Secondary Metabolism, 2/e, H.-J. Rehm & G. Reed (Eds.), Wiley-VCH, Weinheim, 2001.

4-0-0-4 MIBDBT810: ADVANCED BIOCHEMISTRY UNIT I Enzymes: nomenclature & classification; biological roles. Enzymes, Characteristics & Three-Dimensional Structure: chemical nature & characteristics; colloidal & catalytic nature; specificity of enzyme action; thermolability; reversibility of a reaction; pH sensitivity; 3D structure of enzymes; ribonuclease; lysozyme; chymotrypsin. Enzymes, Mechanism of Enzyme Action: energy mechanics of enzyme reactions; MichaelisMenton equation; Lineweaver-Burk equation; significance of Km & Vm values; active site Fischer & Koshland models; enzyme reaction rates; modifiers of enzyme activity activation, regulation & inhibition; reversible & irreversible enzyme inhibition; bisubstrate reactions; allosteric enzymes sequential & concerted models. Metabolic Concepts: definition & terminology; functions of metabolism; classical subdivisions of metabolism; metabolic pathways, central pathways; catabolism & anabolism; unifying themes of metabolic pathways activated carriers, key reactions, modes of regulation; regulation of metabolic pathways; evolution of metabolic pathways. UNIT II 14 periods 16 periods

Bioenergetics: concept of energy, thermodynamic principles; relationship between standard free energy change & equilibrium constant; standard free energy changes at pH 7.0; ATP as universal currency of free energy in biological systems; free energy of hydrolysis of ATP & other organophosphates; structural basis of the high group transfer potential of ATP; ATP hydrolysis & equilibria of coupled reactions; role of high-energy phosphates as the energy currency of the cell; interconversion of adenine nucleotides. Glycolysis: general considerations; ten reaction steps of glycolysis phosphorylation of glucose, isomerization of glucose 6-phosphate, phosphorylation of fructose 6-phosphate, etc.; stoichiometry of glycolysis; anaerobic glycolysis & homolactic fermentation; alcoholic fermentation. Pyruvate Oxidation & Citric Acid Cycle: three stages of cell respiration oxidative decarboxylation of pyruvate and its regulation; Krebs cycle, enzymes involved in the acetylCoA catabolism; seven reaction steps of the citric acid cycle condensation of acetyl-CoA with oxaloacetate, isomerization of citrate into isocitrate, etc.; stoichiometry of the citric acid cycle and energy yield; stereospecificity of the citric acid cycle; regulation of the citric acid cycle substrate levels, enzyme levels, etc.; amphibolic roles of the citric acid cycle biosynthetic roles & anaplerotic roles; glyoxylate cycle. UNIT III 19 periods

Electron Transport & Oxidative Phosphorylation: electron flow as source of ATP energy; site of oxidative phosphorylation; ATP synthetase; electron-transferring reactions; standard oxdation-reduction potential; electron carriers pyridine nucleotides, NADH dehydrogenase, ubiquinone, cytochromes; electron transport complexes of the respiratory chain; incomplete reduction of oxygen; mechanism of oxidative phosphorylation chemical, conformational & chemiosmotic coupling hypotheses; oxidation of extramitochondrial NADH, shuttle systems; ATP yield & P:O ratio; roles of electron transport energy; respiratory inhibitors inhibitors 10

of electron transport, etc.; regulatory controls among glycolysis, citric acid cycle & oxidative phosphorylation. Oxidation of Fatty Acids: lipid metabolism general considerations, activation of fatty acids, oxidation; oxidation of even-chain saturated fatty acids, oxidation pathway; oxidation of unsaturated fatty acids; oxidation of odd-chain fatty acids; oxidation of fatty acids; oxidation of fatty acids; ketogenesis biosynthesis & utilization of ketone bodies, regulation of ketogenesis; fatty acid oxidation in peroxisomes. Biosynthesis of Lipids: acetyl-CoA transport into the cytosol, production of malonyl-CoA, ACP, the fatty acid synthase complex, the priming phase, the elongation phase, stoichiometry; mitochondrial & micosomal fatty acid synthesis; biosynthesis of unsaturated fatty acids; biosynthesis of eicosanoids; biosynthesis of triacylglycerols; biosynthesis of membrane phospholipids in Escherichia coli & in eukaryotes; biosynthesis of cholesterol; biosynthesis of steroid hormones. UNIT IV 11 periods

Oxidation of Amino Acids. Metabolic fates of amino groups: transfer of amino groups to glutamate; removal of amino groups from glutamate; transport of ammonia through glutamine to liver; glucose-alanine cycle. Nitrogen excretion: the urea cycle; the Krebs bicycle; energetics of the urea cycle; genetic defects in the urea cycle. Pathways of amino acid catabolism: degradation of ten amino acids to acetyl-CoA; conversion of five amino acids into -ketoglutarate; conversion of four amino acids into succinyl-CoA; degradation of three branched-chain amino acids in extrahepatic tissues. Inborn errors of amino acid catabolism. Biosynthesis of Amino Acids. Overview: essential & nonessential amino acids; metabolic precursors of amino acids. Nitrogen metabolism: nitrogen cycle; nitrogenase complex; reduction of nitrate & nitrite. Fixation of ammonia into amino acids. Biosynthesis of amino acids: -ketoglutarate precursor family; 3-phosphoglycerate precursor family; oxaloacetate & pyruvate precursor families; phosphoenolpyruvate erythrose-4-phosphate precursor family; ribose-5-phosphate precursor family. Regulation of amino acid biosynthesis. Molecules derived from amino acids: biosynthesis of porphyrins; bile pigments; creatine & glutathione; neurotransmitters; formation of nitric oxide from arginine; auxin. TEXTBOOK Fundamentals of Biochemistry, 6/e, J. L. Jain, Sanjay Jain & Nitin Jain, S. Chand & Co. Ltd, New Delhi, 2005. REFERENCE Biochemistry, 2/e, D. Voet & J. G. Voet, Wiley, New York, 1995.

11

4-0-0-4 MIBDBT811: BIOTRANSFORMATIONS UNIT I Perspectives in bio-transformation [8a. 1: 5-24]. Bio-transformations, practical aspects [8a. 2: 25-36]. Catalytic antibodies [8b. 11: 403-419, brief treatment only]. UNIT II 12 periods 12 periods

Hydrolases, Bio-transformations with lipases [8a. 3: 37-85, brief treatment only]. UNIT III Redox Enzymes, Alkaloids [8a. 7: 327-362]. Yeast [8a.8:363-390]. UNIT IV Carbon-Carbon Bond Formation, using enzymes [8b. 1: 5-40]. Lyases [8b. 2: 41-56, brief treatment only]. UNIT V Industrial bio-transformations [8b. 6: 277-294]. Engineering microbial pathways for amino acid production [8b. 8: 313-332]. 10 periods 12 periods 14 periods

TEXTBOOK Biotechnology, Volume 8, Bio-transformations, 2/e, H.-J. Rehm & G. Reed (Eds.), WileyVCH, Weinheim, 2001.

12

4-0-0-4 MIBTDBT812: PRODUCT QUALITY MANAGEMENT UNIT I: 15 periods

Concepts of quality regulatory factor, QC, QA and GMP, their nature and interrelationships comparison of UK EC and USA GMP wider aspects of quality assurance TQM and ISO 9000 UNIT II: 15 periods

Premises: Contamination control location, structure, design, layout, services and cleaning. Equipment: Materials, cleaning, calibration, international standards, maintenance UNIT III: Personnel management: Training hygiene and health Documentation: General in action UNIT IV: 15 periods 15 periods

Quality control and good laboratory practice analytical validation laboratory documentation and records quality assurance in the manufacture of sterile products self inspection and quality audit statistical process control- hazard analysis critical control points TEXTBOOK Quality in the manufacture of medicines and other health care products, Sharp, Sharp and Sharp, Pharmaceutical press, 2000

13

0-0-3-2 MIBCBT802R01: DOWNSTREAM PROCESSING LABORATORY II Packed Bed Distillation: Estimation of HETP Leaching: Estimation of efficiency Batch Adsorption: Estimation of Freundlich Isotherm parameters Rotating-Disc Extraction Column: Demonstration Packed-Bed Absorption Column: Hydrodynamic Characteristics Ball Mill: Estimation of power consumption Hammer Mill Sedimentation: Estimation of particle size distribution Cyclone Separator: Estimation of collection efficiency Filter Press: Estimation of specific cake resistance Centrifugal Filtration: Estimation of filtration efficiency Rotary Drum Filter Estimation of Stefan-Boltzmann Constant

0-0-3-2 MIBTCBT803R01: BASIC BIOINFORMATICS LABORATORY

Internet basics: URL naming & addressing, effective usage of search engines File transfer protocols: Telnet, HTTP, FTP Basic HTML Web server basics Useful Bioinformatics websites Representation of sequence data Bimolecular structure file formats Bimolecular sequence file formats Sequence retrieval system Structural information of macromolecules Sequence Data Retrieval: ENTREZ, NICEPROT. Sequence Analysis Similarity searching using BLAST and FASTA. Repetitive sequence analysis, regulatory sequence analysis, exon-intron analysis.

14

3-1-0-4 MIBDBT813: TRANSPORT PHENOMENA UNIT I 11 periods Mechanism of momentum, heat & mass transport; Newtons law of viscosity; Fouriers laws of heat conduction; Ficks laws of diffusion; pressure & temperature dependence of viscosity; conductivity & diffusivity; theory of viscosity; conductivity & mass diffusivity; NonNewtonian fluids. UNIT II 10 periods Introduction to shell balances; boundary conditions. Velocity distributions in laminar flow; flow of falling film; flow through circular tube; flow through an annulus; adjacent flow of two immiscible fluids; creeping flow around a solid sphere. UNIT III 15 periods Equations of change for isothermal systems: Equation of continuity; equation of motion; equation of mechanical energy; Eulers equation of motion; Navier-Stokes equation; steadystate flow problems; dimensional analysis of equation of change. UNIT IV 12 periods Temperature distributions in solids: Heat conduction with an electrical heat source; heat conduction with nuclear heat source; viscous heat source; chemical heat source; composite walls; cooling fin. UNIT V 12 periods Concentration distributions in laminar flow: Diffusion through a stagnant gas; diffusion with heterogeneous chemical reaction, homogeneous chemical reaction; diffusion into a falling liquid film; forced-convection mass transfer; diffusion & chemical reaction inside a porous catalyst; effectiveness factor. TEXTBOOK 1. Transport Phenomena, 2/e, Bird, Stewart & Lightfoot, John Wiley & Sons, 2001. 2. Transport Process & Unit Operations, 3/e, J. Christie & G. Koplis, Prentice-Hall of India, 2003. 3. Transport Phenomena, J. Thomson, Pearson Education Asia Ltd., 2001. REFERENCES 1. Fundamentals of Momentum, Heat & Mass Transfer, J. R. Welty, R. E. Wilson & L. E. Wick, John Wiley (ISE), 2001. 2. Momentum, Heat & Mass Transfer, Bennett & Mayers, McGraw-Hill, 1982.

15