The Influence of Ocular Anatomical Variables on

Individual Structure-Function Maps

Jonathan Denniss1,2
Allison M. McKendrick1
Andrew Turpin1,2
1Optometry

& Vision Sciences

2Computing & Information Systems

Purpose

Present an anatomically-customisable
computational model relating VF to ONH

Purpose

Show effects of anatomy on S-F maps

Retina as spherical
surface

Divided into grid

Fovea

Disc

Shortest
path

Ordered growth
2

90

180

270

seq(0.75, 1.04, length = length(0:360))

Fibres bumped according

to room in sector

NRR area=room in sector

50

100

150

200

250

300

350

PM sectors

For each point:

if distance to ONH > d
room in PM sectors

40

!!!
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Fovea
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122412231225

0
20
40

lattitude degrees

20

11871156113311061092109010931125115511681210

DH

ONHy

DV

Customisable
to anatomy

ONHx

Axial Length
ONHx (H position)
ONHy (V position)
DH (H diameter)
DV (V diameter)

H+V cup diameters

Fovea diameter

Simulation: 11550 maps

Axial Length
ONHx (H position)
ONHy (V position)
DH (H diameter)
DV (V diameter)

[20, 21, 22 30] mm

[13, 14, 15 18] degrees
[-1, 0, 1 5] degrees
[1.2, 1.4, 1.6 2.4] degrees
[1.4, 1.6, 1.8 2.6] degrees

Constraint: (DV-0.6) < DH < (DV+0.4)

5% least frequently mapped sectors removed

5% trimmed

1 deg sectors

40

Sectors in retina space

!!!!!!!!!
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0
20
40

lattitude degrees

20

10841041 996 958 941 929 928 939 953 968 985 10271060

40

20

0
longitude degrees

20

40

Jansonius et al
Vis Res 2009; 49: 2157-2163

Garway-Heath et al
Ophthalmology 2000; 107: 1809-1815

bimodal?

Thanks to D.B. Henson

Univ. Manchester, UK

Reducing noise in suspected glaucomatous visual

fields by using a new spatial filter
Gardiner et al.
Vis Res 2004; 44: 839-848

Conclusions
Anatomy affects mapping at many locations
-potential cause of S-F discordance

Model useful for individual eyes where some

simple biometric parameters known
-any retinal location/VF pattern
-any anatomy

Future use

Custom VF test patterns for individual patients

Thank you
Funding:

Supercompu0ng:
Helpful discussion:
Drs. N.M. Jansonius, C. Matsumoto & F. Tanabe

jdenniss@unimelb.edu.au