Cellulose gum as a replacement for Guar gum

The price and availability of guar gum has been the subject of great concern in the pharmaceutical industry recently. WALOCELTM Cellulose Gum can be considered as a replacement for guar gum in a variety of applications. Cellulose gum is widely and consistently available. WALOCELTM CRT A products comply with the regulations and directives in the current version of The United States Pharmacopoeia / The National Formulary (USP/NF), the Food Chemicals Codex (FCC) and the Codes of Federal Regulations of Food and Drug Administration (FDA), Part 21 CFR.182.1745 (GRAS). Property Comparison: Properties Cold and hot water soluble Dissolution time Transparent solution Flavor Viscosity range Viscosity shear Viscosity heat Synergy pH stability Moisture holding Ionic / non ionic Guar gum Medium fast Not transparent, cloudy Bean flavour 5000 -7000 1% Shear thinning Heat thinning with xanthan gum 5 7, loss below about 3.5 Good Non ionic Cellulose gum Fast Very transparent and clear Neutral 30 to 50,000 2% Shear thinning Heat thinning with methyl cellulose with guar Loss below 3.2 Good Ionic

Applications: Cellulose gum can be considered for use in pharmaceutical applications such as syrups and liquid laxatives. Cellulose gums to consider to replace some or all guar gum in your formulation: The viscosity of a typical guar gum is between 3500 and 5000 mPas at 1%; a close match for this viscosity would be WALOCELTM CRT 40000 PA. Higher viscosity grade guars could be matched by WALOCELTM CRT 50000 PA 07. It may be that lower viscosity cellulose gums can be useful for giving different performance characteristics. There is an interesting synergy between cellulose gum and guar gum which could benefit many from a cost in use point of view. In the following chart, the optimum ratio of cellulose gum to guar gum for maximum viscosity is shown for a 1% total concentration of the combined gums.

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9000 8000 7000 6000 5000 4000 3000 2000 1000 0

guar only

expected viscosity actual viscosity

CRT 10000 /guar 20/80

CRT 30000 / guar 30/70

CRT 50000 / guar 35/65

Synergy of cellulose gum and guar combinations wrt viscosity

The synergy produced by combining the gums in ratios between 20/80 and 35/65 gives 2 + times the viscosity of just the combination of viscosity values. This suggests that if manufacturers wish to reduce their usage of guar gum without completely replacing it, they should consider evaluating a blend of guar and cellulose gum in their formulation.

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