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Generally, the effector molecules induce inflammatory response that eliminates antigen without extensively damaging the hosts tissue. Under certain circumstances, however, the inflammatory response can have deleterious effects, resulting in significant tissue injury, serious disease or even death. Such an inappropriate and damaging immune response is termed hypersensitivity.
Classification of Hypersensitivity
Hypersensitivity reactions are divided
2. Antibody-Mediated Hypersensitivity
History
The concept of "allergy" was originally
introduced in 1906 by the Austrian Pediatrician von Pirquet , after he noted that some of his patients were hypersensitive to entities such as dust, pollen, or certain foods. He called this phenomenon "allergy" from the Greek word 'alol', meaning, 'change in the original state, an allergic reaction is the result of the body's change when it adversely responds to a harmless substance.
Allergy
Allergy is a hypersensitivity disorder of the immune system. Allergic reactions occur to normally harmless environmental substances known as allergens. The term allergy is used to describe a response, within the body, to a substance, which is not necessarily harmful in itself, but results in an immune response and a reaction that causes symptoms and disease in a predisposed person, which in turn can cause inconvenience, or a great deal of misery.
Allergy Types
Allergic rhinitis Asthma Atopic eczema Anaphylaxis
Insect venom
Drug allergies Food allergies
the environment known as allergens. Almost anything can be an allergen for someone. Allergens contain protein, which is often regarded as a constituent of the food we eat. In fact it is an organic compound, containing hydrogen, oxygen and nitrogen, which form an important part of living organisms. The most common allergens are: pollen from trees and grasses, house dust mite, moulds, pets such as cats and dogs, insects like wasps and bees, industrial and household chemicals, medicines, and foods such as milk and eggs. Less common allergens include nuts, fruit and latex.
stimulate b cells to form IgE-secreting plasma cells. The secreted IgE molecules bind to IgE-specific Fc receptors on mast cells and blood basophils. Second exposure to the allergen leads to cross-linking of the bound IgE,triggering the release of pharmacologically active mediators cause smooth muscle contraction,increased vascular permeability and vasodilation.
Causes
Common allergens associated with type I hypersensitivity.
protein Plant Pollens Drugs Foods Insect Products Bee venom Mold spores Animal hair and dander Latex
Foreign Serum
Vaccines
Ragweed
Sulfona mides
Symptoms
swelling of the nasal mucosa
allergic sinusitis redness and itching of the conjunctiva Sneezing, coughing, wheezing, sometimes outright attacks of asthma feeling of fullness, possibly pain, and impaired hearing
Skin
Gastrointestinal
Diagnosis
A variety of tests now exist to diagnose
allergic conditions; these include testing the skin for responses to known allergens or analyzing the blood for the presence and levels of allergen-specific IgE.
Treatments
Treatments for allergies include allergen
avoidance, use of anti-histamines, steroids or other oral medications, immunotherapy to desensitize the response to allergen, and targeted therapy. New technology approaches to decreasing IgE overproduction, and regulating histamine release in allergic individuals
Celebrity Allergies
Referances
www.wikipedia.org