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Demographics
Today, the geriatric population makes about 13% of the general population. It is expected to increase to greater than 20% by the year 2030.
Elderly patients however, consumes about 33% of all prescription and OTC drugs . Overall, the elderly have more disease states than the other age groups and therefore require the use of more medications.
Thus effective and safe drug therapy is one of the greatest challenges within the elderly population.
Pharmacokinetics
Is the time course by which the body absorbs, distributes, metabolizes and excrete drugs. In other words, it speaks to how drugs move through the body and how quickly this occurs.
Absorption
Is defined as the movement of a drug from the site of administration, across biological barriers, into the plasma. But as the age increases, it decreases the rate of absorption.
Distribution
Is the movement of a drug from the plasma into the cells. As patient age, total body water declines and fat stores increases.
Pharmacodynamics
Is the time course and effect of drugs on cellular and organ function. In other words, it is what drugs do once theyre in the body.
Drug related problems in the Elderly About one third of drug related hospitalizations occur in persons over 65 years old. Even though medications provide benefit by preventing and treating disease, older people, are more susceptible to drug related problems including adverse drug reactions, polypharmacy, inappropriate prescribing and non compliance
Polypharmacy
It is defined as the prescription, administration, or use of more medications than are clinically indicated in a given patient.
Disease
Benign Prostatic hyperplasia
Drugs Anticholinergics
COPD
Dementia Depression Diabetes Glaucoma HPN HypoKalemia Hyponatremia
B-Blockers
Opioids Corticosteroids Corticosteroids Anticholinergics NSAIDS Digoxin Diuretics,SSRI
Confusion, Delirium
Precipitation or exacerbation ofdepression
Orthostatic
Ostopenia Parkinsons Peptic ulcer
Upper GI bleeding
Compliance
Although age does not affect compliance, about 40% of elder persons do not adhere to their medication regimen. The more complex the medication regimen, the less likely the patient will comply.
Establishing a good relationship with the patient. Providing education about possible side effects Providing clear instructions for how the medication should be taken.
Encouraging questions from the patient And providing home nursing support as needed.
There are several medications available on the market that provide excellent results but are not ideal for use in elderly patients.
Laboratory Values
Lab results for older adults differ from those younger adults thus reference ranges or normals may be different.
Offers few advantages over acetaminophen yet has the same adverse effects as other narcotic meds
Strong cholinergic and sedation effects May cause confusion and sedation
Benadryl
All barbiturates
Highly addictive
Demerol
Catapres
Potential for orthostatic HPN and CNS adverse effects Potential for aspiration and adverse effects Lack of cardioprotective effect in older women; evidence of carcinogenic potential
Mineral Oil
Estrogens only
Medication
Effect
Macrodantin
Cimetadine (tagamet)
Indomethacin
CNS adverse effects; other NSAIDS available with fewer adverse effects Anticholinergic effects, sedation, weakness
Methacarbamol
Increased with Age Alkaline phosphate ANA C-reactive protein Cholesterol, total Clotting factors VII and VIII Copper
Decreases with Age Albumin Aldosterone Serum Calcium HDL cholesterol (women) Creatinine kinase Creatinine clearance
Unchanged with Age Hepatic function test Coagulation tests Biochemical test (serum electrolytes, total protein.) Arterial blood tests Renal function tests Thyroid function tests
Decreases with Age Dihydroepiandrosterone 1,25-dihydroxyvitamin D Estradiol Growth hormone IGF-1 Interleukin 1
Rheumatoid factor
Sedimentation rate Triglycerides Uric Acid
Phosphorus
Platelets Free testosterone Total protein Zinc, serum
Evaluate the bodys ability to metabolize medications. Evaluate the need for medications to treat a condition.
Measuring medication blood levels is important for monitoring the metabolism of the medication so that the correct dosage can be given at the correct intervals to obtain the best results without side effects or adverse effect or adverse drug reactions.
Lab test that is used to monitor the function of kidneys and liver
Blood Urea Nitrogen (BUN) it is used as a gross measure of glomerular function and the production and excretion of urea. Creatinine is a substance removed from the body by the kidneys. Measurement of the creatinin level will give a clue as to the function of the kidneys.
Alkaline phosphatase is an indicator of liver disease. Levels in the blood will rise when excretion of this enzyme is impaired.
Creatinine
Albumin Alkaline phosphate
Renal
Hepatic Hepatic
ALT
AST Direct bilirubin Indirect bilirubin Total Protein
Hepatic
Hepatic Hepatic Hepatic Hepatic
9-51 u/l
13-38 u/l 0.0-0.3 mg/dl 0.1- 1.1 mg/dl 6.0-8.0 g/dl
For medication to work properly, the right drug must be taken in the right amount, by the right route at the right time by the right patient.
Failure to follow these five rights can delay or prevent the outcome intended by the health care provider.
Vision
Another sense that is important to help ensure adherence to prescribed medication to regimens. The ability to find and read the label of medication.
Memory/Cognition
Impaired memory can be a barrier to adherence with medication routiness. Remembering which medications to take and at what times can be difficult if memory is impaired.
Motivation
Is important in adherence to a medication routine. There must be motivation to obtain the medication, to learn about the medication, to take the medication on time and to report inability to take the medication to the physician.
Funding
Many older adults have difficulty purchasing medications due to costs.
Nursing Intervention
Nurses in all settings have a responsibility to help ensure that the five rights are followed for each patient. Specific interventions include:
Medication review Education - ensures that the patient understands the medication instructions etc.
Accommodation note sensory, motor, cognitive limitations that the patient may have that could interfere in the medication Funding assess the patients ability to pay for medications
Tacrine (cognex)
Is taken 4 times a day Can potentially affect the liver, so liver enzymes must be closely monitored. Side effects: Nausea, vomiting, diarrhea, abdominal pain, rash and indigestion.
Donepezil (Aricept)
Probably the most widely used drug although it does not cure Alzheimer or keep it from getting worse. It does help relieve some of the memory loss. Most effective in early stages of the disease. 5mg-10mg per day OD Side effects diarrhea, vomiting, nausea, fatigue, insomnia and weight loss.
Galantamine (Reminyl)
Prevents breakdown of acetylcholine and stimulates nicotinic receptors to release more acetylcholine in the brain. Taken twice a day Side effects diarrhea, vomiting, nausea, fatigue, insomnia and weight loss.
Antiresorptives
Slows the rate of bone remodeling but cannot rebuild bone. Medications in this category include biphosphonates, hormone replacement therapy and SERMs
Chapter 9
Teaching Older Adults
Which is commonly used in teaching adults, has motivation and relevance as two key concepts.
Using andragogy as common principle.
This theory states that self efficacy and outcome expectations affect behavior, motivational level, thought patterns and emotional reactions in response to any situation.
Although older adults still expect the traditional retirement, 69% plan to work post retirement in positions related to teaching, office support, crafts, retail sales or health care. Despite the trends that support postretirement employment, 67% have concerns that age discrimination will be a major barrier in the workplace.
Older learners prefer teaching methods that are easy to access and require small investments of time and money. They expect learning to begin immediately through direct hands on experiences. Reading materials such as newspaper magazines and books are used by 64% of older adults for learning.
Arthritis
May not be able to hold the Highlight area and press mouse and consistently enter to avoid double clicking. clicking Problems with inability to focus. Priming- introduce concepts early on
Attention span
Chapter 10
Promoting Independence in Later Life
This adage, commonly heard, rings true when considering the factors that influence independence in later life. Health, personality, state of mind, and emotional, physical and spiritual support all have a place in the adjustments one makes to aging process.
Although self care and health promotion are indeed important in maintaining independence, aging and accompanying health factors often make this a very difficult period of life. As a person moves from the earlier adjustments of aging (65-75) to the later ones (75-85), circumstances may become even more complex.