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AP Biology
Overview
Cell membrane separates living cell from
nonliving surroundings
thin barrier = 8nm thick selectively permeable allows some substances to cross more easily than others
hydrophobic vs hydrophilic
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Phosphate
hydrophobic
hydrophilic
Fatty acid
Arranged as a bilayer
Phospholipid bilayer
polar hydrophilic heads nonpolar hydrophobic tails
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Membrane is a collage of proteins & other molecules embedded in the fluid matrix of the lipid bilayer
Glycoprotein
Extracellular fluid
Glycolipid
Peripheral protein
Cytoplasm
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Filaments of cytoskeleton
cholesterol in membrane
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Membrane Proteins
Proteins determine membranes specific functions
cell membrane & organelle membranes each have unique collections of proteins peripheral proteins
loosely bound to surface of membrane cell surface identity marker (antigens)
Membrane proteins:
integral proteins
penetrate lipid bilayer, usually across whole membrane
transmembrane protein transport proteins
Why are proteins the perfect molecule to build structures in the cell membrane?
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2007-2008
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into membrane
On outer surfaces of
membrane
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H+
Examples
water channel in bacteria
Porin monomer b-pleated sheets Bacterial outer membrane
COOH
H+
Cytoplasm
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Plasma membrane
Inside
Transporter
Enzyme activity
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Cell adhesion
important in organ & tissue development basis for rejection of foreign cells by immune system
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Any Questions??
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Diffusion
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movement of water
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diffusion
osmosis
NO!
OUT OUT IN
waste ammonia salts CO2 H2O products
polar molecules
H 2O
ions
salts, ammonia
outside cell
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sugar aa
H 2O
large molecules
starches, proteins
inside cell
aa
sugar
NH3 AP Biology
salt
outside cell
channels move specific molecules across cell membrane facilitated = with help no energy needed
high
low
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The Bouncer
Active Transport
Cells may need to move molecules against
concentration gradient
shape change transports solute from one side of membrane to other protein pump conformational change costs energy = ATP low
ATP
high
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The Doorman
Active transport
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antiport
symport
Simple diffusion
diffusion of nonpolar, hydrophobic molecules lipids high low concentration gradient
Facilitated transport
diffusion of polar, hydrophilic molecules through a protein channel high low concentration gradient
Active transport
ATP
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Transport summary
simple diffusion
facilitated diffusion
active transport
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ATP
How about large molecules? Moving large molecules into & out of cell
through vesicles & vacuoles endocytosis
exocytosis
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exocytosis
Endocytosis
phagocytosis
pinocytosis
non-specific process
receptor-mediated endocytosis
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The Special Case of Water Movement of water across the cell membrane
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2007-2008
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Hypertonic - more solute, less water Hypotonic - less solute, more water
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freshwater
balanced
saltwater
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balanced
ATP
plant cells
turgid
freshwater
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ATP
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plant cells
plasmolysis = wilt
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saltwater
1991 | 2003
Peter Agre
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Roderick MacKinnon
Rockefeller
John Hopkins
Osmosis
.05 M
.03 M
Cell (compared to beaker) hypertonic or hypotonic Beaker (compared to cell) hypertonic or hypotonic Which way does the water flow? in or out of cell AP Biology
Any Questions??
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Thank you
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