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Hx:
1. age >65 increases risk 2. drug, alcohol, tobacco use, 3. current medications 4. use alternative therapies 5. past surgeries & how tolerated 6. ALLERGIES
assessment: Neurologic- LOC, motor & sensory fxn, risk falls Cardiovascular & respiratory Renal & hepatic fxn Musculoskeletal fxnarthritis-may affect position
Fluid/e-lyte balance- no K+ imbalances Contageous dxneed to clear up before surgery Medication hx- do need heart, respiratory, seizure meds
Module 7.1: Discuss The Preoperative Assessment Psychosocial assessment: 1. Level of anxiety 2. Ability to cope 3. Family or support persons
Urinalysis- bun, creatinine, fasting glucose, protein, pathogens, sp.gr, e-lyte balance CBC-RBC, WBC Platelet, Hct, Hgb
Pt, PTT INR AST, ASL (liver fxn) Type and crossmatch X-ray, EKG ABGs
Module 7.1: What are the NSG Interventions during the pre-operative period? Hx & physical Baseline Vs, skin prep Preoperative teaching Confirmation informed consent NPO and bowel preparation, administration regular meds, drains, tubes Removal personal items Offer bed pan Administer pre-op drugs, raise side rails i.d pt, surgical site and procedure one last time
Atropine- decrease saliva, gastric juice production and sweat Scopolamine- inhibits emesis and motion sickness Robunol- decreases gastric juices
S.E: dry mouth, orthostatic hypotension, urinary retention, constipation, thick, dry pulmonary secretions, blurred vision, tachycardia
anesthesia: decreases anxiety, induces sleep, relaxes muscles Lorazapam (ativan) Diazepam (valium) Flurazepam (dalmane) Midzolam (versed) S.E: confusion and amnesia
Module 7.1 : What are the Preoperative Medications and their S.E?
Antiemetics
Inhibit nausea and
Antihistamines
vomiting Trimethobenzamide (tigan) Ondansetron (zofran) Aprepitant (emend) Metaclopramide (reglan) S.E: headache, dizziness, diarrhea, fatigue
vistaril)
Informed consent
Discuss criteria informed consent The physicians What is the nurses role in informed consent? To witness that the
responsibility to give informed consent and explain all risks involved, outcomes etc. Involves: Adequate information Understanding and comprehension Voluntary signing
Intraoperative period
Who is responsible for positioning
Allergies?
Common:
Latex Betadine- contained
in shell fish
Intraoperative period
Discuss spinal anesthesia.
Is local anesthesia injected into the
Useful for cardiac and respiratory patients Watch for spinal headache and hypotension
Postoperative period
Complications
Complications
hypoxia check Delayed emergence Confusion , N/V Hypo/hyperthermia Decreased UOP Wound problems: infection, dehiscence, evisceration
Postoperative period
Lab tests, results &
WBC=4000-10000/mm
Neutrophils-55-70% Macrophage-28% Monocyte-3-4% Eosinophil-1-2% Basophil-1%
interpretation:
HCT=35=34%, HgB=12-18g/dL,
platelet=200,000-200,000, RBC=45million PT, PTT, INR- increase suggest bleeding BUN=20-30mg/dL, creatinine=.6-1.0mg/dL Increase suggest kidney problem
Fasting glucose=70-110mg/dL ABG: acidosis/alkalosis E-lytes: Na+ and K+ Liver fxn tests (AST, ASL)-
auscultate BS, maintain airway Monitor cardiovascular status-assess skin temp, pulses, heart rate, BP Musculoskeletal- ask pt move limbs Neurologic- assess LOC, call pts name
Temperature
hypothermia/hyperther mia
Normal temp <100.4 in 1st 24hrs
Fluid/e-lyte- monitor
Assess q2
Compensatory: SNS activated and releases epinephrine and norepinephrine causing vasoconstriction of periphery..shunts blood to heart and brain
s/s: slightly normal BP, tachypnea, cool dry pale skin, thirst
s/s: decreased: LOC, BP, increased: HR, RR, hypothermia, cool, clammy pale skin
refractory: Exacerbation anaerobic metabolism vasodilation and leaky capillaries, proteins leak into tissues, blood pools, respiratory/cardiac arrest DEATH
w/ nsg interventions
3 types sxn: Intermittent- used single lumen tubes- 80-100mmHg High-100-120mmHg not used Continuous-used double lumen tubes-60-120mmHg
to det. If working properly, listen for sxn Connect to NG tube-watch for gastric contents Assess appearance gastric contents Document Check connections q30min for 2hrs to assure proper fxning
Aspirate stomach contents, if >100 or double hold Instil 30-60 cc H2O Administer feeding Instil 30-6- cc H2O
Section 4.2:
Discuss the Types of wound healing 1. Primary intention- wound approximated ex. Surgery 2. Secondary intentionwound allowed to stay open & fill in with granulation tissue ex. P-ulcer 3. Tertiary intention- wound stays open 3-5dys decrease edema and infection, then closed via primary intention ex. Dirty wounds What are the various drains?
Jackson Pratt & Hemovac-
closed systems to maintain sxn, empty drainage, open port and put pressure on device, then recap port to establish sxn Penrose drain- open gravity system Purpose drains= to promote healing of the underlying structures
Systemic complications
1.
2.
3.
4.
5.
Infiltration/extravation- edema above the site, cool skin, leaky fluid, mottled skin D/C, cold compress Thrombosis- clot in vein red, swollen painful site D/C , cold compress Phlebitis-inflamed vein red, pain at site 1. D/C, warm compress Thrombophlebitis- D/C, cold then warm compress Infection- red, pain, drainage, pus 1. D/C, express drainage.
2. 3. 4.
5. 6.
Embolism: air, pulmonary, catheter (place left side &trendelenburg for air, tourniquet catheter) Hematoma- put pressure on site Systemic infection Speedshock-stop infusion, notify DO, VS Circulatory overload- elevate HOB, keep warm, assess edema, decrease rate, notify DO Allergic rx.
Section8.1: Inflammation
Define inflammation
The response of the tissues to damage
Exudate production
Exudate consists dead cell,
Histamine release in
response to injury vasoconstriction followed by vasodilation & influx blood into injured area Fluid, proteins, leukocytes into site, as blood slows leukocytes emigrate into tissues and engulf pathogens. This causes bone marrow produce and release more WBC
WBC, pathogen etc Thromboplastin, fibrinogen and platelets form network to wall off area
Section8.1: Inflammation
Discuss the medications of inflammation (SE)
1. 2.
3.
4. 5. 6. 7.
Decongestants- Sudafed Antihistamines-block histamine effects Sympathomimeticepinephrine CorticosteroidsAntipuritic- topical lotions ex. Calamine lotion Mast cell stabilizercromalyn blocks leukotrines immunotherapy
increases blood flow to the area Cold causes vasoconstriction DO NOT GIVE HEAT WHEN:
1st 24hr after trauma,
Haemorrhaging, Malignant tumour, Skin conditions cause redness, blisters DO NOT GIVE COLD WHEN: Open wound, poor circulation, allergy/hypersensitivity to cold
down
Decreased: metabolism,
UOP, HR (bradycardia) Constipation, dysrhythmias, chest pain activity & cold intolerance Dyspnea Dry, scaly skin MYXEDEMA COMA
s/s:everything speeds up
Warm, moist skin Expthalamous Goiter Tachycardia Increased: RR, HR, BP, metabolism Weight loss Heat intolerance Muscle weakness and wasting Increased tissue sensitivity THYROID STORM
s/s:
Weight gain, acne,
ACTH Restrict fluid & Na+ ingestion Monitor I/O, weight, & sp. Gr Radiation therapy, surgery, bblockers Assess psychosocial needs
Hirsutism, hypervolemia Increased: HR, BP Straie Activity intolerance Hypergylcemia Poor wound healing
radiation (make sure increase fluid intake to help excrete it), SSKIs and thyroid drugs until it is within normal size and fxning.
Causes: excessive ingestion Ca2+ & VitD, increased PTH production, kidney dx s/s: increase: bone fractures, HR, constipation, lethargy, dyspnea, n/v, anorexia, psychosis, arthritis
excretion Administer calcitonin to decrease bone Ca2+ release Administer mithromycin to bind Ca2+ for excretion Labs: Bun, CBC, creatinine, Ca2+ etc Remove parathyroid gland
PRN medications
Give these as needed
experience (nocioception)
Transduction-pain stimulus-
release chemical mediators Transmission-impulse travels to brain to tell of pain Modulation-release of endogenous opioids, serotonin and norepinephrine to inhibit (dampen) painful impulses Perception-you sense the pain
Discuss PCA
Patient controlled analgesia-
permits patients to administer doses of analgesia Predetermined dose administered Safety mechanisms prevent overdose
autoimmune disease.
A hypersensitivity reaction is an overreaction in
response to an invader or injury An autoimmune disease is a disorder in which the body attacks its own cells, failing to recognize self-cells from non-self cells
B-lymphocyte- fxns in antibody-mediated reactions T-lymphocyte- fxns in cell mediated reactions 1. Cytotoxic T- kills cells containing foreign proteins 2. Memory T3. Helper T-CD4+- recognition of self cells 4. Suppressor T-CD8+-inhibits hypersensitivity rxs
antibody-mediated immunity (through the B-cell system). Characterized by the production of antibodies in response to a foreign substance Cell-mediated immunity is initiated through the T-cell system. Responsible for immunity within the cell through the recognition of antigens within the cell.
against: Bacterial viral infections Respiratory gastrointestinal pathogens Cell-mediated immunity protects against: Transplant rejection Tumours Contact hypersensitivity Fungal infections
mediated immunity?
Humoral- bacterial infections, anaphylactic shock,
to an antigen forming an immune complex which releases lymphokines stimulates antigen to destroy the pathogen Ex. Poison ivy, graft rejection, positive TB test, sarcoidosis
Tx: antihistamines,
prednisone
Hypersensitivity 1 type
reactions which are atopic allergic reactions Also involve the release of histamine See an increase in eosinophil count
tongues, & eyes) Mucus production Bronchospasm, stridor Dysrhythmias, rapid weak pulse hypotension
3. 4. 5.
6. 7.
Antihistamines- inhibit effects histamines Decongestants- phenylephrine, pseudophedrine Sympathomimetic- epinephrine Corticosteroids- allergic rhinitis Antipuritic- topical lotions ex. Calamine lotion, camphor, methanol, phenol Mast-cell stabilizer- inhibit release histamines and leukotrinescromalyn (nasalcrom) Immunotherapy- adm. Small amts of allergen in progressive strengths to build immunity.
Hypersensitivity type 2-
Hypersensitivity type 4:
Hypersensitivity type 3: in
response to excessive antigens in system antigen-antibody complex which deposits in blood vessels, tissues and joints.
destroy the antigen tissue damage (no histamine in this rx) Puritis, vesicles, localized burning, scaling
What is the purpose of cellmediated immunity? Provides immunity (protection) within the cell Fights: First Read The Contract: Fungal infections Rejection of transplants Tumours Contact hypersensitivity
which increase their susceptibility to infection? Elderly have decreased immune fxn which increases their risk of infection Have decreased thymus gland which: Decreases amount of differentiation T-cells More pre-curser cells Delayed hypersensitivity response
Autoimmunity is an immune response against self. Antibodys or lymphocytes attack healthy cellscant recognize ex. Lupus, rheumatoid arthritis.
Tx=plasmaphoresis
Complications=hypotension and citrate toxicity Immunodeficiency is the decreased ability of the immune system to protect self due to decreased WBC, improper development or illness ex. Cancer and its treatment
complications? The removal of plasma containing components that cause dx ex. Antigen-antibody complexes Complications: Hypotension Citrate toxicity
antigen or disease Passive immunity results from the induction of antibodys to protect against disease
an antigen
Causes: antibiotics
(penicillin, vanco, tetracycline), insect bite, contrast media, local anesthetic, opiods, food allergies, heat/cold, exercise, insulin, adrenocorticotropic hormone, vasopressin, whole blood and cryoprecipitate, shell fish, pollen
s/s: feelings apprehension, agioedema, bronchoconstriction, wheezes, stridor, weak rapid pulse, dysrhythmias, shock Tx: assess respiratory fxn, put airway and O2, d/c drug causing problem, admin epinephrine, antihistamines, Theophylline, Albuterol, elevate HOB 45 degrees
involving foreign proteins. Complex is deposited in blood vessels, tissues and joints Delayed hypersensitive rx are type 4 reactions involving sensitized T-cells...due to excessive antigens in the system
of CD4 cells (immunity and inflammation) Used to prevent organ rejection in transplants Occurs with the use of corticosteroids, radiation Complications: Increases risk of infection and cancer
mediated immunity there is recognition between the cells that belong to you and those that do not as well as the recognition between normal and abnormal cells
Primary immune
deficiency is congenitalborn with it Secondary immune deficiency occurs due to medical treatment or disease
Having a decrease in T-cells leaves you susceptible to opportunistic infections and disease like cancer
Basic: 2 drugs
Zidovudine &
lamivudine/emtricitabin
Expanded: 3 drugs
Pneumocystis jiroveci
pneumonia Pneumocystis carinii pneumonia Karposi sarcoma Oral candidias Oral hairy leukopenia Varicella zoster Herpes TB
immunosorbent assay Viral load tests- measure amt virus in the blood
multiple partners, anal, vaginal, oral) Blood transfusions Sharing needles Perinatal transmission to newborns Work risk (exposure blood and body fluids)
Good nutrition
Rest Decreased stress
Avoid infections
What is a benign cell? Normal cells growing in the wrong place or at the wrong time.
.
Section 8.3: Cancer: List the characteristics of a normal cell
Limited divisibility Smaller nuclear to
cytoplasm ratio Apoptosis- preprogrammed cell death Differentiated functioneach cell has a specific function for the body Tight adhesion- cells held tightly together by proteins
Morphology: each cell has specific appearance, shape and size Regulated and controlled growth- cells only divide when they have to and when they do it is controlled and regulated Diploid chromosomeshumans have 23 pairs Non-migratory- doesnt wander Contact inhibition- cells stop dividing once surrounded on all sides by cells
Continuous or inappropriate growthnot needed for normal fxn Small nuclear to cytoplasm ratio Specific morphologylook like the parent cells
Specific differentiation
in fxn- performs fxns of parent cell ex. Endometriosiswhen grows abnormal place still acts like endometrial tissue Tight adherence and doesnt wander Has orderly growth and not invasive
cell division Anaplasia- no longer look like the parent cell Loos adhesion- they dont produce fibronecton Migration- wander every-where because of the loose adhesion
ANEUPLOIDY- have broken, lost, damaged too long/short chromosomes Specific fxn lost Does not adhere to contact inhibition
development.
cancer cell
promotion
Any substance which
(they are turned on excessively--overexpressed) by a carcinogen (cancer causing agent chemical, physical or viral) After initiation cell must be able to divide to be cancer
supports or enhances the growth of the cell ex. Hormones like estrogen and insulin
Metastasis
Occurs when a tumour
its own blood supply because the cells in the center become hypoxic TAF(tumour angiogenesis factor) stimulates blood vessel growth Once have blood vessels cells cont grow and divide often change from parent cell allowing it to become more malignant
breaks off from the primary tumour and establishes its own colony
Tissue of origin: 1. Originates glandular tissue=carcinoma 2. Originates connective tissue=sarcoma 3. Originates embryonic tissue=blastoma 2. Biologic behaviour 3. Anatomic site 4. Degree of differentiation1.
What is ploidy?
The classification of cancer
by cellular characteristics
What is staging? The classifying of cancer based on its clinical manifestations
resemble the cells from which they arose Grade2: tumour cells moderately differentiated and have some characteristics of the parent cell Grade3: tumour cells poorly differentiated but tissue of origin can still be established Grade 4: tumour cells poorly differentiated and can no longer determine tissue of origin
Suppressor genes prevent oncogenes from being overly expressed, but when suppressor genes get damaged oncogenes are over expressed causing cells to become cancerous
Immune function
Advancing age Genetic predisposition
Primary prevention: Avoidance known cancer causing agents- ex. Smoking, use of sun block Modifying associated factorsex. Healthy diet, limit alcohol, safer sex Removal at risk tissuesremoval moles, polyps, etc Chemoprevention- use of drugs, chemicals etc ex. Celecoxib and aspirin reduces risk colon cancer vaccination
Yearly mammogram & breast exam women>40 Yearly PAP women >18 Colonoscopy women & men>50 Yearly fecal occult all adults Yearly prostate exam men>50
Section 8.3: Cancer Treatment: What are some treatment modalities for cancer?
Surgery
1.
2.
3. 4.
biopsy -the removal of some/all of the suspected tissue for examination and testing Debunking-(cancer control/cytoreductive)-removal of parts of a malignant tumour decreasing cancer numbers increasing chances of other treatment working Curative- removal all cancer tissue Reconstructive/rehabilitation-increase fxn, appearance or both
Section 8.3: Cancer Treatment: What are some treatment modalities for cancer?
Radiation therapy
the purpose of radiation therapy is to destroy cancer
cells with minimal damage to normal cells. Use least amt radiation to destroy most amt cells
delivered?
Teletherapy- radiation is external to the patient
(distant), patient isnt radioactive. To be effective must irradiate same place daily---so need tattoo it. Brachytherapy-radiation is within the patient as to have direct contact with the tumour, patient is radioactive.
Section 8.3: Cancer Treatment: What are some treatment modalities for cancer?
s/e: Dry skin, erythema ,changes in taste, anorexia, n/v Fatigue Weight loss, xerostomia: dry mouth; mucositis- irritation, inflammation or ulceration mucosa Bone marrow suppression (WBC, RBC, platelets) NSG: Provide periods rest during activities Monitor weight Small frequent meals High protein, high calorie diet Frequent oral care Administer antibiotic, topical /systemic analgesics, antiemetic
Section 8.3: Cancer Treatment: What are some treatment modalities for cancer?
What are the complications of bone marrow suppression?
What tx can be given to help decrease the risk of infection?
Decreased: WBC,
Biological Response
erythrocytes, platelets increases risk infection, hypoxia and fatigue Tendency to bleed Common cause death during tx
Section 8.3: Cancer Treatment: What are some treatment modalities for cancer?
Chemotherapy: How does chemotherapy cure & increase survival times?
By damaging DNA & interfering with cell division Kills metastic cells-systemic tx
Section 8.3: Cancer Treatment: What are some treatment modalities for cancer?
How is chemotherapy delivered?
IV-major complication
Intraarterial-via artery
is extravation-leaks leads tissue damage recommend central vascular device (groshogg, PICC, infusion ports using Huber needle, infusion pumps)
supplies the tumour Intrathecal-injecting chemo into subarachnoid space Intravisical-into the bladder
Section 8.3: Cancer Treatment: What are some treatment modalities for cancer?
S.E:
1. 2. 3. 4. 5. 6.
n/v
7.
Hemorrhagic cystitis Heart damage Anemia Neutropenia (decreased neutrophils) Thrombocytopenia Alopecia Mucositis
Causes
Excessive intake Renal failure Corticosteroids Cushings syndrome Diabetes insipidus Heat stroke
Causes:
Excessive diaphoresis Diuretics Wound drainage Renal dx NPO Low intake
Causes
v/d Heavy perspiration Use K+ wasting drugs Poor intake Hyperaldosteronism For those on digoxin monitor
IV PUSH!!!!! s/s:
Muscle weakness, leg
NSG: Monitor HR, administer K+, monitor pain, eat K+ rich foods, safety
shock
starvation
Kidneys compensate by
blowing off CO2 to compensate, so CO2 levels fall in response (blow off the acid)