CLINICO-THERAPEUTIC MANAGEMENT OF

CANINE PARVOVIRAL GASTRO-ENTERITIS

Signalment:Animal Pup Species Canine Breed Lhasa Apso Sex Male Age 7 months Colour White Parity Body wt. 5.3 kg

Anamnesis:Vomiting Diarrhoea Lethargic Inappetance Not vaccinated

OBSERVATIONS:Temp Resp Pulse MM Dehydration : 105F : 35/min : 96/min : Congested : 6-10%

Vomitus

Faeces

Haematemesis

INVESTIGATION & LABORATORY FINDINGS:F/S:- No ova of parasitic importance could be detected.

Ancylostoma, Coccidia- Ruled out

RBC count :4.5 million/cu.mm (5.5-8.5) Total WBC :12000/cu.mm(6000-17000) DLC Neutrophils :70% (60-70) Lymphocytes : 30%(12-30) ESR : 8mm/hr (5-25) Hb :13.6g% (12-18) Platelet count :2,90,000/cu.mm(2-9 lakhs) VPRC :43% (37-55) MCV :72 fl (60-77) MCHC :31% (32-36)

Lateral flow technique:-

H A Test (Titres from 1/128 to 1/256)

Titre-1/128

H I Test (Titres from 80 to 120)

Titre- 128

TREATMENT GIVEN:1 st day,

1.Inj. Moxel- 500mg Aqua dest ad 5ml Mft.Sig. 5ml I/V 2.Inj.Metrogyl Sig 10 ml I/V 3.Inj.Botropase Sig 1ml as I/V 4. Inj. RANITIDINE
Sig 0.25 ml I/M

5.INJ.EMESET sig 0.2ml I/V 6. Inj. Haemaccel Sig 50 ml I/V 6.Inj.DNS Sig 100 ml I/V 7.Inj.RL Sig 100 ml I/V

1.Inj. Moxel- 500mg Aqua dest ad 5ml Mft.Sig. 5ml I/V 2.Inj.Metrogyl Sig 10 ml I/V 3.Inj.Pantocid Sig 1.2ml I/V 4.Inj.Emeset Sig 0.2ml I/V 5.Inj.DNS Sig 100 ml I/V 6.Inj.RL Sig 100 ml I/V

1.Inj. Moxel- 500mg Aqua dest ad 5ml Mft.Sig. 5ml as I/V 2.Inj.Pantocid Sig 1.2ml as I/V 3.Inj.Emeset Sig 0.2ml as I/V 4.Inj.DNS Sig 100 ml as I/V 5.Inj.RL Sig 100 ml as I/V 7.Inj.Metrogyl Sig 10 ml as I/V 8.Inj.Botropase Sig 1ml as I/V

th,5th,6th,7th Days 4 3rd,4th & 5th - Gradual Improvement

6th

- Showed thirst, Fluid therapy & Anti-emetics stopped

- Normal appetite

7th

Follow up:Soft & Easily digestible diet 24 hr clean water Warmth Vaccination of other pups

Review after 10 days

survival rate

Survived-6, Dead-1

14%

86%

Canine parvo virus -2 Small, non enveloped, ss DNA 2a, 2b, 2c-strains Close relation- FPV, MEV Disease of young to adolescent dogs. Breeds: Rottweiler, Dobermann, German shepherd, Labrador, Staffordshire terrior Myocardial or Intestinal form.

Principally by faecal-oral route

oral, nasal or oronasal exposure IM, IV, S/C In utero infection

Pathogenesis :Oronasal exposure

Regional lymph nodes,pharynx,tonsils

Viremia
Lymphoid tissue, Bone marrow Leukopenia Intestine Crypt necrosis Enteritis, Diarrhoea Lung,Liver,Kidney Minimal pathology

Severe
Gram negative sepsis

Mild Recovery

D.I.C

DEATH!!

Less than 8 weeks of age In utero or oronasal exposure

Cardiac arrhythmia, Cardiac

myopathy, CHF, Pulmonary oedema.

Fever
Vomiting Diarrhoea Depression, anorexia , lethargy

Myocarditis- CHF

DIAGNOSIS
RAPID DIAGNOSIS
Antigen dependant immunochromatographic

method: Lateral flow technique

RAPID LATERAL FLOW TEST

-ve

+ve

SLIDE AGGLUTINATION TEST

ELISA

PCR

ELECTRON MICROSCOPY

HA HI TEST

DIFFERENTIAL DIAGNOSIS
Ancylostoma caninum infection Coccidiosis Corona virus infection Canine distemper

Foreign body
Poisoning

ARRIVE AT A CONFIRMED DIAGNOSIS AT THE EARLIEST!

TREATMENT
Supportive and Symptomatic

OBJECTIVE
Replacement of fluid loss Prevention of secondary bacterial infection Rest to the G I tract
Antibiotics

Haemocoagulants

H2 blocker

Antiemetic 5HT3 blocker

VACCINATION

Inactivated.

Live attenuated/ Modified live.

Whole agent

Sub -unit

6-8 week. 6,9,12,15,18,22week. Once in a fortnight. Weekly. Annual booster. Our Hospital- 12 weeks, 18 week, Annual.

Puppy-DP - Nobivac DHPPiL -Biocan Companion-C3 -Intervet Progard puppy-DP Canigen Virbac Duramune Max PvFort Dodge Megavac-6 - IIM

Formaline- 1% Ethyl alcohol-50-95% Ethylene Oxide F10, Trigene

Treat diseases..?

A HEALTHY POPULATION OF ANIMALS

Craig E. Greene, Infectious Diseases of the Dog and Cat, 5th Edition, 2006, W.B.Saunders Company, pp1387.
Max J. Appel, Virus Infections of Carnivores, Vol.2, 1987, Elsevier Inc., pp.500. Stephen J. Ettinger, Edward C. Feldman, Textbook of Veterinary Internal Medicine, Vol.2, 6th Edition, 2005, Elsevier Inc.,pp1992. ***********************