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Introduction
The
cardiovascular system is a transport system bringing nutrients to and returning waste products from the tissues. This system is divided into two main parts:
The circulatory system, consisting of the heart, which acts as a pump, and the blood vessels through which the blood circulates. The lymphatic system, consisting of lymph nodes and lymph vessels, through which colourless lymph flows.
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Introduction (Cont. 2)
The heart pumps oxygen-rich blood via the arteries, arterioles and capillaries to the tissues. Venules and veins bring oxygen-poor blood back to the heart, which shunts it to the lungs to be oxygenated via the pulmonary circulation.
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Carbon dioxide (CO2) is eliminated by the lungs, and other waste products are eliminated by the kidneys. Lymph return some substances that have leaked from the capillaries into the tissues back into the venous system. The exchange of nutrients and waste products in tissues involves the capillaries.
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Introduction (Cont. 4)
The right side of the heart pumps blood to the lungs (the pulmonary system) where gas exchange occurs (CO2 leaves the blood and enters the lungs, and O2 leaves the lungs and enters the blood) The left side of the heart pumps blood into the systemic circulation, which supply the rest of the body; here, tissue wastes are passed into the blood for excretion, and the body cells extract nutrients and O2.
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Blood Vessels
Artery, arteries (arteria = a; arteriae = aa) Arterioles, arterioles (arteriola; arteriolae) Capillaries Venule, venules (venula; venulae) Vein, veins (vena = v; venae = vv)
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The relationship between the heart and the different types of blood vessel.
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The blood vessels that transport blood away from the heart. Vary considerably in size. Their walls consists of three layers:
Tunica adventitia or outer layer of fibrous tissue. Tunica media or middle layer of smooth muscle and elastic tissue Tunica intima or inner lining of squamous epithelium called endothelium.
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Find out the variation of the amount of muscular and elastic tissue amongst blood vessels (Histology).
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Anastomoses are arteries that form a link between main arteries supplying an area (e.g. the arterial supply to the palms of the hands). If one artery supplying the area is occluded anastomotic arteries provide a collateral circulation. End arteries are the arteries with no anastomosis.
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The blood vessels that return blood at low pressure to the heart. Its wall are thinner than those of arteries (what make them different and why?). Some veins posses valves (where the valves abundant and where they absent, and why?) The smallest veins are called venules (venulae, plural; venula, singular)
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Interior of a vein
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The smallest arterioles break up into a number of minute vessels called capillaries. Describe the structure of a capillary wall! The capillary bed is the site of exchange of substances between the blood and the tissue fluid, which bathes the body cells. Sinusoids are wider than capillaries and have extremely thin walls separating blood from the neighbouring cells. The blood pressure in sinusoids is lower than in capillaries and there is a slower rate of blood flow (Why?)
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Blood Supply
The outer layer of tissues of thick-walled blood vessels receive their blood supply via a network of blood vessels called vasa vasorum. Vessels with thin walls and the endothelium of the others receive oxygen and nutrients by diffusion from the blood passing through them.
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The Heart
The heart is a roughly cone-shaped hollow muscular organ. It is about 10 cm long and is about the size of the owners fist. It weighs about 225 g in women and is heavier in men (about 310 g)
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Lies in the thoracic cavity in the mediastinum between the lungs. Lies obliquely, a little more to the left than the right, and presents a base (basis) above, and apex below. The apex is about 9 cm to the left of the midline and the level of the 5th intercostal space (spatium intercostale), a little below the nipple and slightly nearer the midline. The base extends to the level of the 2nd rib.
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Inferiorly (identify) Superiorly (identify) Posteriorly (identify) Laterally (identify) Anteriorly (identify)
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The pericardium
is
made up of two sacs; the outer sac consist of fibrous tissue and the inner of a continues double layer of serous membrane (See Snell, RS. Clinical Anatomy)
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The pericardium
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Myocardium
Composed of specialized cardiac muscle found only in the heart. Not under voluntary control but, like skeletal muscle, cross-stripes are seen on microscopic examination. Thickest at the apex and thins out towards the base (Why?) Each fibre (muscle cell) has a nucleus and one or more branches.
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Cardiac muscle
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Myocardium
The atria and the ventricles are separated by a ring of fibrous tissue that does not conduct electrical impulses (Why this is important?)
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Endocardium
This forms the lining of the myocardium and the heart valves. It is a thin, smooth, glistening membrane which permits smooths flow of blood inside the heart. It consist of flattened epithelial cells, continous with the endothelium that lines the blood vessels.
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The heart is divided into right and left side by the septum (septum interatriale and septum interventriculare), a partition consisting of myocardium covered by endocardium. After birth blood cannot cross the septum from one side to the other. Each side is divided by an atrioventricular valve into an upper chamber, the atrium, and a lower chamber, the ventricle.
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The valves
Valve (valvula = valva) Valvula atrioventriculare dextra (valvula tricuspidalis) Valvula atrioventriculare sinistra (valvula bicuspidalis). The valves open and close passively according to changes in pressure in the chambers.
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Arterial supply Left and right coronary arteries Venous drainage Coronary sinuses Little venous channels (whats the name) (See Sobotta)
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groups of specialized neuromuscular cells in the myocardium which initiated and conduct impulses causing coordinated and synchronized contraction of the heart muscle.
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SA-Node AV-Node AV bundle or bundle of Hiss Purkinje fibres Normally, SANode is the Pacemaker
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The heart is an intrinsic system whereby the cardiac muscle is automatically stimulated to contract without bthe need for a nerve supply from the brain. However, the system can be stimulated of depressed by nerve impulses initiated in the brain (autonomic nervous system) and circulating chemicals including hormones.
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Autonomic nervous system (How this system influencing the heart rate) Circulating chemicals (the homones adrenaline and noradrenaline Whats their effects). Position (upright, lying down)
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Exercise (autonomic nervous system!!!) Emotional states. Gender Age Temperature Baroreceptor reflex.
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Explain!!!
Heart sounds Cardiac output Stroke volume Venous return Blood pressure Control of blood pressure
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Heart Sounds
A heartbeat produces the familiar LUB-DUP sounds as the chambers contract and the valves close. The first heart sound, lub, is heard when the ventricles contract and the atrioventricular valves close. This sound lasts longest and has a lower pitch. The second heart sound, dup, is heard when the relaxation of the ventricles allows the semilunar valves to close.
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Heart murmurs, which are clicking or swishing sounds heard after the lub, are often due to ineffective valves. These leaky valves allow blood to pass back into the atria after the atrioventricular valves have closed, or back into the ventricles after the semilunar valves have closed. A trained physician or health professional can diagnose heart murmurs from their sound and timing. It is possible to replace the defective valve with an artificial valve.
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Location of valve sound on chest wall (Further learning: Snells Clinical Anatomy)
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Pulse
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Main arteries of the left side of the head and the neck
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The superior vena cava and the main veins of the thorax
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Venous drainage from the abdominal organs and the formation of the portal system
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Ductus arteriosus
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