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Drug Calculations
November 2007
1g=
1,000 mg
1 mg =
1,000 micrograms
1L=
1,000 mL
Answers
0.25 1000 or move decimal point three places to the RIGHT = 250 micrograms
600 1000 or move the decimal point three places to the LEFT = 0.6 mg
A patient is prescribed 200mg of Furosemide I.V. The ampoules available contain 250mg in 10mL. What volume containing the drug do you need to administer? Furosemide
Time
0700-0900 1200-1400
What it is IN
Dose 200mg
Route
Start Date
IV
18.05.07
End Date
1600-1800
2200-2400
Other Time
Furosemide 250mg/10mL
Signature of Doctor
P.Rescriber
What we
WANT
Answer
What you WANT X what it is IN What you have GOT 200 mg 250 mg 10 mL
= 8 mL
A patient is prescribed 250mg of Aciclovir I.V. Aciclovir has to be initially reconstituted with water for injection, then added to a bag of compatible infusion fluid, giving a final concentration of 5mg/mL. How much infusion fluid should be used dilute the reconstituted Aciclovir to achieve this final concentration?
Aciclovir
Time 0700-0900
1200-1400
1600-1800 2200-2400
Dose 250mg
Route
Start Date
IV
18.05.07
End Date
Other Time
Signature of Doctor Additional Comments P.Rescriber
What we
HAVE
CONCENTRATION
Answer
What you HAVE (mg) CONCENTRATION (mg/mL)
250mg 5mg/mL = 50 mL
A 1% (w/v) solution means that in every 100mL of solution you will find 1g of drug. Therefore, how many g of Glucose would there be in 500mL of 5% Glucose?
Glucose 5% 500ml
Answer
A 1% (w/v) solution means that in every 100mL of solution you will find 1g of drug. 100mL = 1g Therefore a 5% w/v must mean that 100mL = 5g Multiply each side by 5 500mL = 25g
1:10,000 strength means that in every 10,000ml of solution you will find 1g of Adrenaline. Therefore, how many mg of Adrenaline would there be in 10mL of 1:10,000 Adrenaline?
Answer
1:10,000 means that 1g of adrenaline is dissolved in 10,000mL. 1g = 10,000mL 1000mg = 10,000mL Divide both sides by 1000 1mg = 10mL
SECTION 4: Duration of Infusion Stated rate (dose per min) Infusion rate (mL/hr)
Stated Rate dose per min
Dose (mg) = Time Rate (mg/min)
Furosemide must be administered at a rate no faster than 4mg/minute. How many minutes would it take to give 200mg of this drug? Furosemide
Time
DOSE (mg)
Dose Route Start Date
0700-0900 1200-1400
200mg
IV
18.05.07
End Date
Furosemide 250mg/10mL
Signature of Doctor
P.Rescriber
Additional Comments
Rate of 4mg/minute
Rate (mg/min)
Answer
Dose (mg) = Time Rate (mg/min)
200mg 4mg/min = 50 minutes
Omeprazole (Losec ) 40mg is diluted in 100mL of compatible infusion fluid. This infusion has to be given over 20 minutes. What rate should you set the infusion pump at, in ml/hr, to deliver this dose?
Omeprazole 40mg/100mL
Answer
Volume (mL) = Time (mL/hr) x 60 Rate (hr)
100ml 20 mins x 60 = 300mL/hr
Acetylcysteine (Parvolex ) 7.5g is diluted in 1000mL of compatible infusion fluid. This infusion has to be given over 16 hours. What rate should you set the infusion pump at, in ml/hr, to deliver this dose?
Acetylcysteine 7.5g/1000mL
Answer
Dose (mL) = Time (mL/hr) Rate (hr)
1000 16 = 62.5 mL/hr
You are required to give a patient Glyceryl Trinitrate as a continuous I.V infusion at 25 micrograms/minute. You have prepared a 50mg in 50mL infusion. What rate should you set the infusion pump at, in ml/hr, to deliver this dose? What we
Glyceryl Trinitrate
What we
Time 07000900 12001400
have
GOT
Glyceryl Trinitrate 50mg/50mL
WANT
Dose Route Start Date
25 micrograms/ IV minute
18.05.07
End Date
60 mins per hr
Signature of Doctor
P.Rescriber
Additional Comments
Continuous Infusion
What its IN
Answer
What you WANT x 60 (60 mins per hr) What you have GOT X what it is IN
25 micrograms x 60 = 1500 micrograms/hr 1500 1000 = 1.5 mg 1.5 mg x 50mL 50 mg = 1.5 mL/hr
Any Questions?
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