Professional Documents
Culture Documents
BY
Prof.Dr/ Ahmed
Gamal AZab
Definition
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Pathology
Characteristicclusters of lymphocytes
( lymphorrhages) in between the muscle
fibres.
Thymus gland : may show hyperplasia or a
thymic tumor (thymoma) .
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Incidence
Female : male = 2 : 1
Mean age of onset : 26y in F, 30y in M.
Close relationship w/thyrotoxicosis, SLE,
rheumatoid arthritis, biliary cirrhosis, M.S,
and cancer.
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Clinical picture
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Diagnosis
1- Clinical fatigue tests : inducing fatigue by asking the
patient to count to 100 { > dysarthria } or maintain
looking up { > ptosis } .
2- Prostigmine test { 1.5mg prostigmine + 0.5mg
atropine IM }.
3- Tensilon test { edrophonium HCL} : 2mg iv
followed,if no idiosyncrasy ,by 8mg > improve
myasthenia after a minute.
4- EMG : repititive stimulation test >diminished
amplitude after repeated stimulation .
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Diagnosis { cont..}
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Crisis in Myasthenia
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Lambert-Eaton(myasthenic-myopathic)
syndrome
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