NINA ROSYIDAH NOVI WIRAKUSUMAH SELLY BERMAWI SITI NURAINI WAHYUNI YULIANI FARIDA JAFAR

GENERAL

GENERAL
Tuberculosis is a disease of respiratory tract infections are common in Indonesia. Delay in diagnosis and adherence to treatment has a great impact because TB patients will transmit the disease to the environment, so the number of patients is increasing. If not treated properly the disease can lead to death for the sufferer.

PREVALENCE
Based on WHO 2011, in 2010 Indonesia ranked fourth highest number of Tuberculosis sufferers world after India , China, South Africa. http://www.globalhealthfacts.org/data/topic/map.aspx?ind=12

PREVALENCE
In Indonesia Prevalence of Tuberculosis in 2010, the highest are: Gorontalo 6.9 %, West Papua 6.7 %, East Nusa Tenggara 6.5 % , Central Sulawesi 5.4 % and Jambi 5.3 % (http://www.litbang.depkes.go.id/sites/download/b uku_laporan/lapnas_riskesdas2010/Laporan_riske sdas_2010.pdf)

SYMPTOMPS AND DIAGNOSE

Symptoms of TB
Cought and phlegm countinously

for 3 weeks or more Blood sputum Shortness of breath Chest pain Loss of appetite and weight loss fever more than a month weakness

DIAGNOSIS
Clinical symptoms Physical examination Bacteriological examination Examination of sputum or sputum microcopically Chest x-ray

METHOD
x-ray to determine the spots that exist in the lungs Sputum examination

TREATMENT
TRADE MARK GENERIC

INHA 400 ( Isoniazid, Vit B6) Dosage: Adults 4-5 mg/kg/daily, maximum 300 mg/daily. Children 10-20 mg/daily. Side effects: peripheral Neuritis, optic neuritis, nekrotis anti-hepatotoxic, insomnia, hypersensitivity reaction, agranulocytosis, hepatitis (mainly in patients > 35years), other side effects that occur are the mouth feels dry.

RIFAMPICIN (RIMACTANE)
Dosage and Adminitration: Mycobacterial Infection:Tuberculosis: Adult Weighing ,50kg: 450mg daily; 50kg: 600mg daily. Children: 1020 mg/kg daily. Maximum permissible daily dose : 600mg Side effects: The most common is skin rash, fever, reddish of urine, sputum, nausea and vomiting

TREATMENT
TRADE MARK
RIMACTAZID Rifampicin, Isoniazid Dosage and Administration : Adults: Rimactazid 225/200 is intended for use in patients weighing 47-50kg; patients in this weight group, with regard to body constitution, are in a relativety good state of nutrition. Patients with body weight <50kg: one Rimactazid 450/300 captab daily. The usual dosage is 2 captabs once daily = 450mg rifampicin + 400mg INH.
Pharmacology: Rifampicin inhibits the DNA-dependent RNA polymerase of sensitive bacterial strains. Isoniazid is a specific antituberculoos agent exerting a strong bacteridal effect mainly on rapidly growing population of Mycobacterium tuberculosis

conclusion and management care

conclusion Tuberculosis is a disease of respiratory tract infections. usually its showed by spesific symptoms such as: Blood sputum, Cought and phlegm countinously for 3 weeks or more. Delay in diagnosis and adherence to treatment has a side effect because TB patients will transmit the disease to the environment. If not treated properly the disease can lead to death for the sufferer Management care give BCG immunization in infants Avoid contact with infected person

Prevention is better than cure

THANKYOU