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Figure 15-4 Transmembrane potential (Vm) of a cardiac muscle fiber varies inversely with the potassium concentration of the external medium. The straight line (EK) represents the change in transmembrane potential predicted by the Nernst equation for potassium. (Redrawn from Page E: Circulation 26:582, 1962.)
Figure 15-5 Concentration of sodium in the external medium is a critical determinant of the amplitude of the action potential in cardiac muscle (upper line) but it has very little influence on the resting membrane potential (lower line). (Redrawn from Weidmann S: Elektrophysiologie der Herzmuskelfaser, Bern, 1956, Verlag Hans Huber.)
Pacemaker (SA node) action potential: Lowers the resting membrane potential (resting Em ) phase 4 slope no change in sinus rate (heart rate)
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Electrocardiography (ECG)