Professional Documents
Culture Documents
Immune System
NonSpecific
Specific
Phyisic / Mechanic
- Intact Skin - Mucus - Coughing - Sneezing - Saliva, tears, - perspiration, - urine, - Vomiting,diarrhea
Humoral
- Biochemic
- Lysozyme - Neuroam ac - Lactoferrin
Cellular
- Phagocyt - PMN - MN -Cell Nol
Humoral / B Cell
-Imm. Glob - IgM - IgG - IgA - IgD - IgE
Cellular / T Cells
- Th Cell - Tc Cell - Ts/ Tr Cell - Tdth Cell
- NK Cell
- K Cell - Mediator Cell - Eos
- Mast, etc
COMPLEMENT MEDIATORS
A L T E R A L T
MAC
INTERFERON
Interaksi antara molekul2 kostimulator mengatifkan sel T yg dalam keadaan istirahat. Aktifasi oleh APC: melalui TCR & kompleks MHC Tapi tanpa disertai 2 kostimulator (B7) anergi
M cell
Gastrointestinal epithelium
APC
Ag
T Helper / CD4 T cell
MHC class II
TCR
TH1
TH3
TH2
INF- TGF-
IgG
Cellular immunity
IgM IgA
Target cell
Humoral immunity
Hipersensitivitas
2a
5a
6a
8a
9a
29d
30d
31d
Autoimun
Persistent pathogenic autoantibodies Persistent pathogenic immune complexes Persistent damaging autoreactive T cell
Uptake of autoantigen
Some self-antigens are sequestered in specialized tissues and cannot be expressed in the thymus or bone marrow. These are not seen by the developing immune system will not induce self-tolerance. Exposure of T cells to these normally sequestered/tissuespecific self-antigens in the periphery results in their activation.
Antinuclear antibodies
Anti-ss-DNA antibody Anti-ds DNA antibody Anti-polyADP ribose antibody Anti-Scl-70 antibody Anti-centromere antibody Anti-histone antibody
Disease
SLE etc. SLE SLE SSc CREST Drug induce lupus
Chromatin
Anti-U1RNP antibody Anti-Sm antibody Anti-U2RNP antibody Anti-SS-A/Ro antibody Anti-SS-B/La antibody
Nucleus
Anti-PCNA antibody
U1RNP U1, U2, U4/U6, U5 RNP U2RNP hY1~hY5 RNP RNA polymerase III trancription termination factor DNA polymerase auxiliary factor DNA dependent protein kinase activation factor
Type II Hypersensitivity
30-90%
70-95% 50-80% 15-40%
Sm
SS-A (Ro) SS-B (La) Cyclin I (PCNA)
5-30%
20-60% 10-20% 3%
Ku
Ribosomal P proteins Cardiolipin, -2-glycoprotein 1
5-10%
5-20% 20-40%
Malar rash Discoid rash Photosensitivity Oral ulcers Arthritis Serositis Neurological disorder seizure psychosis . Renal disorder proteinuria > 0.5g Casts
Haematologic disorder Haemolytic anemia leukopenia lymphopenia thrombocytopenia Immunological disorder anti-dsDNA anti-Sm anti-phospholipids ANA positivity
Rheumatoid arthritis
Autoantibodies against
Histones
Prevalence
Rare
8%
90-95%
Rheumatoid factors
Fillagrin (keratin)
65-90%
50%
Type IV Hypersensitivity
Defisiensi imun
1.
Struktur HIV
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