Shrey Bhatia

Syndrome
A syndrome is a pattern or collection of symptoms that together indicates a disease

What is Syndrom X ?
collection of symptoms of overall poor health that are also risk factors that increase a persons chance of developing CVD and diabetes

Individuals with MSyn have a 3040 percent probability of developing diabetes and/or CVD within 20 years

MSyn is a complex web of metabolic factors that are associated with a 2-fold risk of CVD and a 5-fold risk of diabetes.

Insulin resistance
Insulin resistance is a particularly important

part of the Metabolic Syndrome equation It can be defined as an impaired response to the physiological effects of insulin, including those on glucose, lipid, and protein metabolism, and the effects on vascular endothelial function.

Complex Dyslipidemia
TG, LDL HDL

Endothelial Dysfunction

Systemic Inflammation

IGT

Insulin Resistance

Atherosclerosis

Hypertension Type 2 Diabetes

Visceral Obesity

NATION USA
7 European countries
South Asia

PREVALANCE OF Metabolic Syndrome

25%

23%
20-25%

European Group for the Study of Insulin Resistance (1999)

Top 25 percent of fasting insulin values among nondiabetic individuals AND two or more:
Central obesity: waist circumference 94 cm (male), 80

cm (female) Dyslipidemia: TG 2.0 mmol/L and/or HDL < 1.0 mmol/L blood pressure 140/90 mmHg Fasting plasma glucose 6.1 mmol/L

American Heart Association/ Updated NCEP

Elevated waist circumference:
Men >40 inches Women > 35 inches

Elevated triglycerides: 150 mg/dL Reduced HDL

Men <40 mg/dL Women <50 mg/dL

Elevated BP: 130/85 mm Hg or on HTN medication

Elevated fasting glucose: 100 mg/dL or use of medication

for hyperglycemia

Total of 548 subjects from Mumbai participated in the study. On applying modified NCEP ATP III, Overall prevalence Males Females 19.52% 25.16% 12.6%

The age-wise distribution of prevalence of MS was found to be the same in 2040 and 4160 age groups (20.61% and 20.76%) Volume 2011 (2011), Article ID 920983, 7 pages
doi:10.1155/2011/920983Clinical Study Prevalence of Metabolic Syndrome in Urban India Apurva Sawant,1 Ranjit Mankeshwar,2 Swarup Shah,1 ,1

Out of 300 subjects selected , over all presence of MSyn as per ATP-III was 5 percent Higher in females ( 7%) as compared to males ( 3%)
Indian med j res 132 December 2010 Printa Kamble, Pradeep k Deshmukh

1.

The term Metabolic Syndrome is a way of identifying individuals at high risk for the development of heart disease and diabetes

2. 3. With the help of various definitions of metabolic

syndrome , high risk group should be identified

4. They should receive education and counseling on

lifestyle modification, and all risk factors for heart disease should be treated promptly and seriously.