Professional Documents
Culture Documents
BY DR SANA BUSHRA
Target cells
These contain excess membrane or insufficient haemoglobin and are recognized as target like with red peripheries, central pallor and with a dot of haemoglobin at the centre Post splenectomy Haemoglobinopathies(sickle cell,thalassemia disease plus trait) Severe iron deficiency Obstructive jaundice
Anisocytosis
Variation in size of erythrocytes Iron deficiency anemia Beta thalassemia Megaloblastic anemia
Poikilocytosis
Variation in shape of erythrocytes Severe iron deficiency Beta thalassemia
Heinz bodies
Denatured hemoglobin / hemoglobin remnant stained by supravital staining seen as a dark dot in erythrocyte. Red cell enzyme defects ( e.g G6PD deficiency , pyruvate kinase deficiency) Drugs and chemicals causing haemolytic anaemia
Rouleaux formation
Erythrocytes stacked in rows one on another Inflammation Malignancy
Spherocytes
Seen as spherical cells with no central pallor; give rise to a low MCV Hereditary spherocytosis Immune haemolytic anemia Severe burns Post transfusion
Continued
Combination of iron deficiency with a B12/folate deficiency Iron deficiency anaemia (with microcytosis) and having received a blood transfusion
Basophil stippling
Seen as numerous small dots in the red cell due to alpha chain clumping Lead poisoning Beta thalassemia
Acanthocytes
Red cells with spiny projections protruding from the surface Post splenectomy Abetalipoprotenemia