Fundamentals of Nanotechnology: From Synthesis to Self-Assembly

Nanotechnology in Cancer Treatment

Background and Introduction

Cancer Development of abnormal cells that divide uncontrollably which have the ability to infiltrate and destroy normal body tissue 1

Chemotherapy

Use of anti-cancer (cytotoxic) drugs to destroy cancer cells. Work by disrupting the growth of cancer cells
Nonspecificity
2

Toxicity Adverse side effects Poor solubility

 Cancer Nanotechnology
interdisciplinary research, cutting across the disciplines of
Biology Chemistry Engineering Physics Medicine Nanoparticles such as Semiconductor quantum dots (QDs) Ion oxide nanocrystals Carbon nanotubes Polymeric nanoparticles Unique Properties
Structural
3

Optical Magnetic

Molecular Cancer Imaging (QDs)

Tumor Targeting and Imaging

Emission wavelengths are size tunable (2 nm-7 nm) 4

High molar extinction coefficients

Conjugation with copolymer size-tunable optical properties of ZnS-capped CdSe QDs improves biocompatibility, selectivity and decrease cellular toxicity 5

 Correlated Optical and X-Ray Imaging High resolution sensitivity in detection of small tumors 6 x-rays provides detailed anatomical locations Polymer-encapsulated QDs No chemical or enzymatic degradations QDs cleared from the body by slow filtration or excretion out of the body

Early Cancer Detection

Early cancer detection by carbon nanotubes Oligonucleotide modified carbon nanotubes as the high-resolution atomic force microscopy tips to determine targeted DNA sequences

can detect change in single base mismatch in a kilobase size DNA strains 7 Nanowires
Metallic , semiconductor or polymer composite nanowires functionalized by ligands such as antibodies and oligonucleotides capturing the targeted molecules the Nanowires changes the conductivity 8 Detect up to 10 X 10-15 concentrations

Targeted Cancer Therapy

Active targeting

Conjugating the nanoparticle to the targeted organ, tumor or individual cells for preferential accumulation 9

dendrimers are synthetic, spherical, highly branched and monodispersed macromolecules

Biodegradable polyester dendrimers Intracellular release of drug component Tunable architectures and molecular weights to leads to optimize tumor accumulation Polyester dendrimer based on 2,2-bis(hydroxymethyl)propionic acid and drug delivery.

Nanoparticle Drugs
Designed by encapsulating, covalently attaching or adsorbing therapeutic and diagnostic agents to the nanoparticle 10 Recently Food and Drug Administration (FDA) approved AbraxaneTM an albumin -paclitaxel (TaxolTM) nanoparticle drug for the breast cancer treatment. Nanoparticle structure was designed by linking hydrophobic cancer drug (Taxol) and tumor-targeting ligand to hydrophilic and biodegradable polymer. Delivers 50% higher dose of active agent TaxolTM to the targeted tumor areas.

Feature Directions
The first major direction in design and development of

nanoparticles are monofunctional, dual functional, tri functional and multiple functional probes. Bioconjugated QDs with both targeting and imaging functions will be useful in targeted tumor imaging and molecular profiling applications. Consequently nanoparticles with three functional groups could be designed for simultaneous imaging and therapy with targeting. The second direction is to study nanoparticle distribution, metabolism, excretion and pharmacodynamics in in vivo animal modals. These investigations will be very impotent in the development and design of nanoparticles for clinical applications in cancer treatment.

Reference
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