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Intracellular Fluid (ICF) : 40% Interstitial Fluid (ISF) : 15%} Intravascular Fluid (IVF) : 4% } 20% Transcellular Water (TCW) : 1-2%} (joints, CSF, pleural cavity, peritoneal cavity; eye, GI secretions)
Fluid Movement
Hydrostatic Pressure: Moves fluid across a pressure gradient (Fluid moves from capillaries to ISF by hydrostatic pressure) Will not move if BP
Fluid Movement
Osmotic Pressure Moves from an area of lesser solute concentration to greater concentration. Low serum protein shift to ISF
DEFINITION OF EDEMA
The Accumulation of Abnormal Amounts of Extravascular
Classification
1) Interstitial pitting edema 2) Intracellular edema non pitting edema
Interstitial Edema
Edema Fluid in interstitial tissue Occurs when hydrostatic pressure or osmotic pressure moves fluid into third space.
Edema
Causes: Colloid osmotic pressure (kidney disease) Capillary permeability (inflammation; burns) Capillary hydrostatic pressure (congestive heart disease) Lymphatic obstruction (cancer) Sodium & water excess (renal failure)
TYPES OF EDEMA
GENERALIZED LOCALIZED
Inflammation Lymphatic Obstruction Venous Obstruction Thrombophlebitis Chronic lymphangitis Resection of reg lymph nodes Filariasis CARDIAC HEPATIC RENAL NEPHROTIC SYNDROME ACUTE GN CRF IDIOPATHIC Malnutrition Other Cyclic Myxedema Vasodilator-induced Pregnancy-induced Capillary leak syndrome
Pathogenesis of edema
Starling forces Capillary damage Reduction of effective arterial volume Reduced cardiac output Renal factors The renin-angiotensin-aldosterone (RAA) system Arginine vasopressin (AVP) Endothelin Natriuretic peptides
odema
DEMA
CARDIAC EDEMA Diagnosis History of Heart Disease Cardiac enlargement Evidence of Pulmonary Edema Orthopnea Exertional Dyspnea Basilar rales Evidence of Volume Expansion Venous distention Hepatic Congestion Hepatojugular Reflux Ventricular Gallop Rhythm
Pulmonary Edema
HEPATIC EDEMA Diagnosis History of Liver Disease Evidence of Chronic Liver Disease Spider Angiomas Palmar Erythema Jaundice Hypoalbuminemia Evidence of Portal Hypertension Venous Pattern on Abdominal Wall Esophogeal Varices Ascites
LIVER DISEASE
Liver Cirrhosis
Ascites
Renal Na Retention
Systemic Edema
RENAL EDEMA Diagnosis History of Renal Disease Evidence of Albumin Loss Proteinuria Hypoalbuminemia
RENAL EDEMA Diagnosis Nephrotic Syndrome Hyaline Casts Oval Fat Bodies Lipid Droplets/Casts Acute Glomerulonephritis Hematuria Erythrocyte Casts Leukocyte Casts Pyuria
Urinalysis
Hypoalbuminemia
Renal Na Retention
Systemic Edema
CARDIAC
HEPATIC
RENAL
Absent
Absent
Severe/Moderate
Absent/Trace
Severe
DISTRIBUTION OF EDEMA Important guide to the cause One leg or to one or both arms Venous and/or lymphatic obstruction Resulting from hypoproteinemia generalized especially in eyelids and face Facial edema : trichinosis, allergic reactions, myxedema Associated with heart failure : more extensive in the legs
ASCITES
DEFINITION FREE FLUID IN THE ABDOMINAL CAVITY
JAMA 1992;267:2645-2648
PATHOPHYSIOLOGY OF ASCITES
HYDROSTATIC PRESSURE
CIRRHOSIS CHF CONSTRICTIVE PERICARDITIS
OSMOTIC PRESSURE
NEPHROTIC SYNDROME MALNUTRITION PROTEIN LOSING ENTEROPATHY
SHIFTING DULLNESS
METHOD OF EXAMINATION BEGIN BY PERCUSSING AT THE UMBILICUS AND MOVING TOWARD THE FLANKS. THE TRANSITION FROM AIR TO FLUID CAN BE IDENTIFIED WHEN THE PERCUSSION NOTE CHANGES FROM TYMPANIC TO DULL. ROLL THE PATIENT ON THEIR SIDE AND PERCUSS AS BEFORE. THE AREA OF TYMPANY WILL SHIFT TOWARDS THE TOP AND THE AREA OF DULLNESS TOWARDS THE BOTTOM.
JAMA 1992;267:2645-2648
Reference
Kasper DL, Braunwald E et.al Harrisons Principles of Internal Medicine,16th Ed, Mc-G raw Hill, 2005: 212 - 216