AMIRAH ZAINAB BINTI MAMAT@MUHAMMAD

10-3-41

General architecture of the main salivary glands

Stroma Parenchyma Secretory units(acini) Myoepithelial cells Types of Acini Duct System

Stroma
CT component of salivary gland that support and convey vascular and nervous supply. CT tissue capsule- cover and separate CT septa (trabeculae)arise and divide Reticular stromainfiltrated by lymphocytes and plasma cells

Parenchyma
Secretory units ( Acini)
Acini ( blind sac) Unit structure formed of group of secretory cells surrounding a lumen and resting on a basement membrane. Acini ( serous/mucous/mixed) Cells are separated from the basal lamina by modified epithelial cell( basket cells/ myoepithelial cells)

 Myoepithelial cells
Flattened, branched cells with many processes that acinus like( basket ) Form hemidesmosomal junctions with basal lamina and desmosomal junctions with acinar and ductal cells they embrace. Contain in their cytoplasm abundant actin and myosin filaments which mediate contraction of these cells and squeeze the acinar secretion into the duct. Surround also the cells lining the duct system particularly the intercalated ducts. Myoepithelial cells acquire a spindle shape and lie parallel to the length of the duct.

Types of acini found in salivary glands

Mucous acini Serous acini Mixed acini

Mucous acini

Serous Acini

Mixed Acini

Duct system
The intralobular ducts The interlobular ducts The interlobar ducts The main duct

Intralobular ducts

Intercalary ducts
thin walled ducts lined by flat or low cuboidal cells. Drain the secretory units directly Represent first segments of the intralobularducts Add bicarbonates and adsorb chlorides from the serous acinar secretion. Very short or absent in mucous glands.

The secretory striated ducts

Intercalary ducts unite together to pour into larger segments of the intralobular ducts called the secretory striated ducts. Salivary glands appear as relatively large, eosinophilic rounded or oval structures with a wide lumen. Lined by cuboidal or low columnar cells with indistinct boundaries. Have central rounded nucleai and eoisiniophilic granular cytoplasm. The basal cell membrane forms deep infoldings lodging mang regularly arranged mitochondria(striated appearance) denote active ion transport across the basal membrane. Pump sodium out of the cells and add water to modify saliva as it passes through them.

The interlobular ducts

As terminal part of the striated secretory ducts leave the lobules, they unit to form larger ducts with a wider lumen. Found within the interlobular connective tissue septa between the lobules Lined by tall columnar epithelium.

The interlobar ducts

larger ducts formed by the union of the interlobular ducts as they continue into the interlobar septa between the lobes. Lined by tall columnar epithelium

The main duct

Terminal duct of the salivary gland, which opens into the oral cavity. Formed by union of interlobar ducts Lined at its beginning by stratified columnar epithelium which gradually becomes non keratinized stratified squamous epithelium similar to that lining the oral cavity where it opens.

References
http://www.pathologyoutlines.com/topic/salivary glandsnormalhistology.html http://www.vivo.colostate.edu/hbooks/pathphys /digestion/pregastric/salivary.html http://www.vetmed.vt.edu/education/curriculum /vm8054/labs/lab17/examples/exglandstruc7.htm http://quizlet.com/13878953/histology-chapter11-salivary-glands-textbook-and-power-pointand-xerostomia-flash-cards/