Gold Collection Hallmark findings

Autosplenectomy

Sickle cell anemia: switch a glu val in chain Low O2 increased sickling Aplastic crisis w/ B19 (Parvovirus ssDNA) infection Salmonella osteomyelitis Vaso-occlusive painful crisises Hydroxyurea as Txt (increased HbF) & Bone marrow transplant

 Brushfield Spots

 Downs

 Call-Exner Bodies

Granulosa cell tumor: associated w/ endometrial hyperplasia & carcinoma Granuloma-Theca cell tumor

 Charcot Triad

 Multiple sclerosis = nystagmus, intention tremor, scanning speech

 Cold Agglutinins

Mycoplasma pneumoniae Infectious mononucleosis

 Cotton Wool Spots

HTN Aka, cytoid bodies seen w/ SLE (yellowish cotton wool fundal lesions)

 Curschmanns Spirals

 Bronchial asthma

 Donovan Bodies

Granuloma inguinale (STD)

 Glitter Cells

Acute Pyelonephritis

 Michealis-Gutmann Bodies

Malakoplakia lesion on bladder due to macros & calcospherites (M-G Bodies): usually due to E. Coli

 Non-pitting Edema

Myxedema Anthrax Toxin

 Owls Eye Cells

CMV Reed Sternburg Cells (Hodkins Lymphoma) Aschoff cells seen w/ Rheumatic Fever

 Pautriers Microabscesses

Mycosis fungoides (cutaneous T-cell lymphoma), Sezary

 Psammoma Bodies

Papillary adenocarcinoma of the thyroid Serous papillary cystadenocarcinoma of the ovary Meningioma Mesothelioma

 Rash on Palms & Soles

2Syphilis RMSF Coxsackie virus infection: Hand-FootMouth Disease

 Reinke Crystals

Leydig cell tumor

 S3 Heart Sound

LR Shunt (VSD, PDA, ASD) Mitral Regurg LV Failure

 S4 Heart Sound

Pulmonary Stenosis Pulmonary HTN

 Schwartzman Reaction

 Neisseria meningitidis impressive rash with bugs

 Smith Antigen

SLE (also anti-dsDNA) Malar Rash, Wire loop kidney lesions, Joint pain, False (+) syphilis test (VDRL) 90% 14-45 yo females also seen w/ use of INH; Procainamide; Hydralazine = SLE-like syndrome

 Thyroidization of Kidney

 Chronic pyelonephritis

 Warthin-Finkeldey Giant Cells

Measles

 Whipples Triad

CNS dysfunction Hypoglycemic episodes - glu injection reverses CNS Sympts

 Ground Glass on chest x-ray (Hyaline)

Due to Pneumocystis carinii Seen w/ Atelectasia

 Honey Combing of the lung

Seen w/ Asbestosis (a restrictive lung disease)

 PAS(+) Dutcher Bodies

 Waldenstroms Macroglobulinemia = increased IgM = Hyperviscosity

 Ground Glass in Abdomen(Hyaline)

 Seen in the hepatocytes of healthy carriers of HBsAg in liver biopsies

 Ground Glass Appearance (Hyaline)

Seen w/ Progressive Multifocal Leukoencephalopathy oligodendrocytes Nuclei seen in Papillary CA of the thyroid (malignant)

 Devics Syndrome

Neuromyelitis Optica A variant of multiple sclerosis: rapid demyelination of the optic nerve & spinal cord w/ paraplegia

 c-erb B2

 Breast Cancer association

 Foster-Kennedy Syndrome

A tumor causing blindness & loss of smell w/ papilloedema

 Red Nucleus Destruction

 Intention tremors of the arm

 Ventral Spinocerebellar tr.

 Unconscious proprioception of lower extremities

 Dorsal Spinocerebellar tr.

 Unconscious prorpioception & fine motor movements

 Cuneocerebellar tr.

 Unconscious proprioception & fine motor movements of upper extremities

 Ventral Spinothalamic tr.

 Light touch perception

 LMN Lesion

Werndig Hoffman (progressive infantile muscular atrophy) Poliomyelitis

 Sensory Pathway Lesion

Subacute Combined Degeneration = Friedrichs Ataxia = B12 deficiency Tabes Dorsalis (Neurosyphilis)

 Suprachiasmatic Nucleus

 Controls circadian rhythm

 Ventromedial Nucleus

 Satiety center. Savage behavior & obesity when lesioned

 Lateral Nucleus

 Induces eating. Starvation when lesioned

 Arcuate Nucleus

 Releases PIF (dopaminergic neurons)

 Acanthocytes

 RBSc w/ spiny projections. Seen in Abetalipoproteinemia.