Professional Documents
Culture Documents
Kamil
memon
ENDOCYTOSIS OF M.TB
UNCHECKED
MYCOBACTERIUM
BACILLARY
PROLIFERATION
TUBERCULOSIS
Kamil
memon
Kamil
memon
GI
A
EP NT
ITH CE
C EL LL
CA ELL OID
NE SEO
C R US
OS
IS
Kamil
memon
Primary
Secondary
Hyperplastic caecal
Kamil
memon
Common in india ( in ileoceacal region)
Etiopathogenesis
Kamil
memon
Predominant changes are in the mesentric
lymph node without any significant lesions
in the intestines
Gross
Kamil
memon
• Microscopy
– Initial stage:primary
complex or Ghon’s focus
– Mesentric lymph nodes
are affected with so
typical tuberculous
granulomatous
inflammatory reaction
with caseous necrosis.
– Tuberculous peritonitis
may occur due to
spread of infection.
Kamil
memon
Etiopathogenosis
◦ It occurs due to swallowing of sputum in patient
with active pulmonary TB
◦ Most commonly in the terminal ileum rarely in the
colon
Kamil
memon
• Intestinal lesions are prominent than lesion in
regional lymph nodes.
• Lesion begin in the peyer’s patches or the
lymphoid follicle with formation of small ulcer
that spread through the lymphatics to form
large ulcers which are transverse to the long
axis of the bowel.
• Ulcers coated with caseous material
• Serosa may be studded with visible tubercles.
• Advance cases transverse fibrous strictures and
intestinal obstruction are seen
Kamil
memon
Mucosa and submucosa show ulceration
and muscularis may be replaced by variable
degree of fibrosis.
Tuberculous peritonitis may be observed
Kamil
memon
Secondary to Pulmonary TB
Gross
Caecum or ascending colon are thick walled
Kamil
memon
Presense of caseating tubercles distinguish
condition from Crohn’s disease in which
granulomas are noncaseoating
Kamil
memon
Kamil
memon