Professional Documents
Culture Documents
Professor Meng
Yunlian
Introduction
Dendritic cells
Langerhans cells in epidermis
Interdigitating cells in spleen and lymph nodes
Follicular dendritic cells in lymphoid nodules
Microfold cells in small intestine
Function of APCs
APCs have the capacity to capture the antigens, and
to partially digest the protein of antigen into small
peptides. The lymphocytes can only recognize the
small peptides presented by APCs. In this way,
APCs transport the antigens to lymphocytes and
elicit the immune response.
Mononuclear phagocytic system (MPS)
Name Location
Monocyte Blood
Macrophage C.T., lymph node,
spleen
Kupffer cell Liver
Alveolar macrophage Lung
Osteoclast Bone
Microglia CNS
Interdigitating cell Lymphoid tissue
Langerhans cell Epidermis
Major Histocompatibility Complex (MHC)
Germinal center
middle sized lymphocytes large
lymphoblasts
Lymphoid organs
Subcapsular sinuses
Peritrabecular sinuses
Medullary sinus
Blood
circulation
Function
①An efficient surveillance.
②Promote the communication among immune
system.
③Provide for more rapid and more persistent
immune responses.
Spleen
The spleen is the largest lymphoid organ of the body.
Structure
Capsule The capsule of spleen is the visceral layer of
peritoneum which is formed by connective tissue with
smooth muscles and mesothelium.
Trabeculae connective tissue with smooth muscles.
Parenchyma lymphoid tissue
white pulp, red pulp and marginal zone
spleen.ppt
White pulp
Periarterial lymphatic sheath
T cells surround the central artery forming
Periarterial lymphatic sheath. There are also some
macrophages and interdigitating cells.
thymus dependent area
Lymphoid nodules (splenic corpuscle)
B cells
white pulp.ppt
Red pulp
Splenic cord lymphoid cord, including T cell , B
cell, plasma cell, macrophages, and blood cells.
Place for filtering blood
Splenic sinus specialized capillary; rod-like
endothelium, incomplete basal lamina, large spaces
between endothelium; large and irregular lumen.
This permits blood cells to pass through the wall of
splenic sinus freely.
red pulp.ppt
Marginal zone
It is between the white pulp and red pulp, about
100um width. There are T cells, B cells, macrophages
and numerous APCs.
Marginal sinusoids the branches of central artery,
channels for lymphocytes entering lymphoid tissue
from blood.
This region seems to be specialized for bringing
antigens (confined to circulating blood )into contact
with lymphocytes in the spleen so that an appropriate
immune response can be started against the antigens.
Blood supply of spleen
splenic A trabecular A
penicillar Arterioles
Open circulation
Closed circulation
splenic sinuses splenic cords
splenic vein
blood circulation.ppt
Lymph vessels of the spleen
Traditionally, it has been held that in the spleen lymph
vessels are confined to the capsule and trabeculae.
Recent studies have shown, however, that they are
present in all parts of the spleen. Lymphocytes
produced in the spleen reach the blood stream mainly
through the lymph vessels.
Functions
Filter blood The spleen acts as a filter for worn out
red blood cells. Normal erythrocytes can change shape
and pass easily through narrow passages. However,
cells that are aged are unable to change shape and are
trapped in the spleen where they are destroyed by
macrophages.