infection of bone and bone marrow of more than 6 weeks duration characterised by recurrent attacks of inflammation with sinuses discharging. Used to be common sequel to acute haematogenous osteomyelitis. Nowadays, frequently follows an open fracture or operation.
Common organisms Usual causative organisms: S. aureus E. coli S. pyogenes Proteus Pseudomonas S. epidermidis (commonest in the presence of foreign implant)
Pathology Acute OM commonly leads to chronic OM because of > 1 of these reasons:
1) delayed & inadequate tx:
causes spreads of pus within the medullary cavity & subperiosteally
death of a part of the bone (sequestrum formation) 2) type & virulence of organisms body defense mechanism may not be able to control
4) iatrogenic joints replacements & internal fixation of fracture.
Chracterised by formation of a sequestrum, involucrum and discharge of pus.
Clinical Features Chronic discharging sinus Commonest presenting symptoms Onset of sinus may be traced back to an episode of acute OM during childhood Often sinuses heal for short periods, only to reappear with each acute exacerbation Sero-purulent thick pus H/o extrusion of small bone fragments from the sinuses Pain Usually minimal but may become aggravated during acute exacerbations Swelling, redness Malaise, fatigue Non-healing ulcer, deformed/non-united bone Fever (only during acute exacerbation) Physical Examination Chronic discharging sinus Fixed to underlying bone Sprouting granulation tissue at its opening, indicating a sequestrum within the bone Sequestrum may be visible at the mouth of the sinus itself Sinus may be surrounded by healed puckered scars (previous healed sinuses)
Thickened, irregular bone Compare the girth of the affected bone with the normal side Tenderness On deep palpation Usually mild Adjacent joint May be stiff Either due to excessive soft tissue scarring around the joint, or because of associated arthritis of the joint
Investigations Blood ESR: During acute flares: CRP, WCC may be Antistaphylococcal antibody titres may be elevated
Pus culture Organisms cultured from discharging sinuses should be tested repeatedly for antibiotic sensitivity With time, they often change their characteristics and become resistant to treatment
X-ray: - Bone resorption - thickening, irregular & sclerosis of the cortices (surrounding bone). - Sequestra (dense fragments) - Bone cavity - an area of rarefaction surrounded by sclerosis. - Involucrum & cloacae. Radioisotope scintigraphy (bone scan): - sensitive but not specific. - increased uptake at metaphysis.
Treatment Principal of treatment: mainly surgical Antibiotics: During acute exacerbations During post-operative period The aim of surgical intervention is Removal of dead bone Elimination of dead space Removal of infected granulation tissue and sinuses
Operative procedures 1) Sequestrectomy Removal of sequestrum If it lies within the medullary cavity, a window is made in the overlying involucrum & the sequestrum removed Must have adequate involucrum formation before performing sequestrectomy
2) Saucerization A bone cavity is a non-collapsing cavity so that there is always some pent-up pus inside it. This is responsible for the persistence of infection The cavity is converted into a saucer by removing its wall. This allows free drainage of the infected material.
3) Curettage The wall of the cavity, lined by infected granulation tissue, is curettaged until the underlying normal- looking bone is seen. The cavity is sometimes filled with Gentamicin impregnated beads to fill up the dead space. 4) Excision of an infected bone Affected bone can be excised en-bloc without compromising the functions of the limb Close the gap by Ilizarovs method of transporting a viable segment of the bone from adjacent part. 5) Amputation May be preferred in a case with a long-standing discharging sinus, especially if the sinus undergoes malignant change.
Complications Acute exacerbation or flare up Occurs commonly Subsides with a period of rest and antibiotics
Growth abnormalities Shortening when growth plate is damaged Lengthening increased vascularity of the growth plate d/t nearby osteomyelitis Deformity - part of the growth plate is damaged & the remaining keeps growing
A pathological fracture May occur through weakened area of the bone Conservative treatment Joint stiffness May occur because of scarring of the soft tissues or a secondary infection of the joint Sinus tract malignancy A rare complication It occurs many years after the onset of osteomyelitis Squamous cell carcinoma Need amputation Amyloidosis