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Summary of Medications Role in Psychiatry
Why Medications ?
• Antipsychotics
• Antidepresants
• Anxiolytics
• Hypnotics
• Cognitives
• Psychostimulants
Psychopharmacologic Drugs
Work over A Spectrum
Antipsychotics
Antipsychotics
Treat psychotic symptoms.
Divided into first (typical) and second (atypical)
agents.
Typical/1st generation = D2 receptor antagonist
1. TYPICAL ANTI-PSYCHOTICS
A. Phenothiazine Derivatives
• Aliphatic Derivative: CHLORPROMAZINE
• Piperidine Derivative: THIORIDAZINE
• Piperazine Derivative: FLUPHENAZINE,
PERPHENAZINE, TRIFLUOPERAZINE
C. Butyrophenone: HALOPERIDOL
CLASSIFICATION OF ANTI-PSYCHOTIC DRUGS
2. ATYPICAL ANTI-PSYCHOTICS
• CLOZAPINE
• RISPERIDONE
• SERTINDOLE
• ZIPRASIDONE
• OLANZAPINE
• QUETIAPINE
Typical Antipsychotics
D2 Receptors
Other Receptors
Side Effects of Antipsychotics
High-Potency Low-Potency
Extrapyramidal
Seizures
Symptoms Sedation
Tardive Dyskinesia Orthostatic
Hyperprolactinemia Hypotension
Neuroleptic
Agranulocytosis*
Anticholinergic side
Malignant
Syndrome (NMS)* effects
Weight gain
General principles about adverse effects
Typicals
Atypicals
Risperidone (4-8)
Haloperidol (5-15) Olanzapine (10-
20)
SYNDROME
§ catatonia, stupor, fever, unstable BP,
myoglobulinemia after weeks of
treatment
§ Mechanism: antagonism of dopamine
Neuroleptic Malignant Syndrome
• Triad:
– Extreme muscular rigidity.
– High fever.
– Fluctuating blood pressure.
• Investigation:
– CPK
• Treatment:
– ICU
– Promocriptine
5. PERIODIC TREMOR RABBIT
SYNDROME
Ø Peri-oral tremors after months or years of
treatment
Ø Mechanism : unknown
Ø Rx: Anti-parkinson’s Drugs
6. TARDIVE DYSKINESIA
Supersensivity of D receptors
(cholinergic def)
Ø oral-facial dyskinesia, choreoathetosis,
dystonia
Ø After months or years of RX
Ø Worse on withdrawal
ADVERSE EFFECTS
B. BEHAVIORAL EFFECTS
qPseudo-depression; toxic confusional state
Ø “ browning of vision”
CLINICAL INDICATIONS
A. PSYCHIATRY INDICATIONS
• SCHIZOPHRENIA
• SCHIZO-AFFECTIVE DISORDERS
• MANIC EPISODES IN BIPOLAR DISORDERS
• GILLES DE LA TOURETTE SYNDROME
• SENILE DEMENTIA
B. NON-PSYCHIATRIC INDICATION
• ANTI-EMETIC EFFECT
• ANTI-PRURITIC EFFECT
• PRE-OPERATIVE ANESTHESIA
Antidepressants
Antidepressants
Antidepressants
Remarks Examples Group
Anticholinergic S/E Amitriptyline, nortriptyline Tricyclics
Antihistamine S/E Imipramine & Clomipramine
Adrenergic S/E
As TCA Maprotiline, amoxapine Tetracyclics
• Depressive Disturbances
• Affective Disorders
• Obsessive-Compulsive Disorders
• Panic Disorders
• Eating Disorders
• Psychosomatic Disorders
• Posttraumatic Stress Disorder
• Alcohol and Drugs Withdrawal Symptoms
• Pain Syndromes
• Enuresis
• Narcolepsy
Side Effects of Antidepressants
SSRIs
TCAs
Dry mouth
Constipation
Headache Blurred vision
GI upset Orthostatic
Sedation hypotension
Sexual dysfunction Sedation
Anxiety Conduction
abnormalities
Confusion
Monoamine Oxidase Inhibitors (MAOI)
• Side effects:
– Decrease dose and follow up for relapse.
– Change mood stabilizer
• Early Toxicity:
– Stop lithium
– Encourage fluid intake (oral +/- I.V)
– Follow up for signs deterioration.
• Late Signs of toxicity:
– Stop lithium.
– I.V fluids/Dialysis
Sodium Valproate
• Anticonvulsant.
• Mood of action as mood stabilizer is
not certain.
• Main side effects:
– Weight gain.
– Hair loss
– Liver impairment.
– Teratogenecity.
Anxiolytics
Benzodiazepines
Long Acting Intermediate Short-acting
Clorazepate Clobazam
dipotassium
Lorazepam
Estazolam
Antiparkinsonism
Antiparkinsonism
• Biperidin HCl – Akineton 2mg.
• Diphenhydramine – Benadryl 50mg
• Amantadine – Symmetrel 100mg
• Benztropine mesylate – Cogentin
2mg
• Trihexyphenidyl HCl – Artane 2mg
•
others
Others
• β β λ ο χ κ ε ρ σ
• Cholinesterase inhibitors:
Donepezil, Rivastigmine,
Galantamine.
• Sympathomimetics:
Methylphenidate,
Dextroamphetamine.
Prescribing a Psychotropic Agent
• Making a diagnosis
• Choose a medication:
► Family or personal hx of response
• Starting dose
• Monitor side effects & clinical response
• Adjust dose if needed
•
Failure of Response; What to do?
• Poor Compliance?
•
• Wrong Diagnosis?
•
• Subtherapeutic Dosage?
•
• Subtherapeutic Duration?
•
• Substance Abuse?
•
• Drug-Drug Interaction?