Professional Documents
Culture Documents
MY
SMS 1084
Dr. Mohanad R. Alwan
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Protection & Nutrition of CNS
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Protection
• Bone
– Cranial bones & vertebral arches
• Meninges
– Dura mater
– Arachnoid mater
– Pia mater
• Cerebrospinal fluid (CSF)
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Meninges
Definition
Meninges = membranes covering the brain
and spinal cord
They are
1. Duramater
2. Arachnoid mater
3. Pia mater
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Meninges
• Dura mater
• Arachnoid mater
• Pia mater
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Duramater
Two layers of dense fibrous tissue
In the skull outer layer takes the place of periosteum
on the inner surface of the skull
Inner layer covers the brain
Forms a partition between the two cerebral
hemispheres called the falx cerebri
Between the cerebellar hemispheres – falx cerebelli
Between the cerebrum and cerebellum – tentorium
cerebelli
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Spinal Dura mater
• Foms a loose sheath around the spinal cord
• Extends from the foramen magnum to the S2 vertebra
• Then it invests the filum terminale
• Fuses with the periosteum of the coccyx
• It is an extension of the cerebral dura
• It is separated from the periosteum of the vertebrae
and ligaments within the neural canal by the epidural
space.
• Applied anatomy : epidural space – epidural
anaesthesia
• Subarachnoid space of the spinal canal – spinal
anaesthesia
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Arachnoid mater
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Pia mater
• Inner most layer of the meninges
• Fine connective tissue
• Contains minute blood vessels
• Closely invests the brain
• Completely covers the convolutions
• Dips into fissures
• Invests the spinal cord
• Beyond the end of the spinal cord continues as the
filum terminale
• Pierces arachnoid mater and with dura mater fuses
with periosteum of the coccyx
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Meninges - Arachnoid and Pia
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Cerebrospinal Fluid
• Similar to blood plasma
composition
• Formed by the choroid
plexus
• Forms a watery
cushion to protect the
brain
• Circulated in arachnoid
space, ventricles, and
central canal of the
spinal cord
Slide 7.46
Cerebrospinal fluid (CSF)
• Production: floor of the lateral ventricle
and third ventricle, by choroid plexus.
From Johanson CE
CSF volume in human
• Total: 164.5 ± 47.8 ml
• Ventricles: 31.9 ± 17.8 ml
• IIIrd ventricle: 0.95 ± 0.62 ml
• Extraventricular: 132.6 ± 43.2 ml
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Function of CSF
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Cerebrospinal fluid (CSF)
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Circulation of cerebrospinal fluid
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Ventricles and Location of the Cerebrospinal
Fluid
Figure 7.17a
Slide
What is the Blood Brain Barrier?
• Structural and functional barrier which
impedes and regulates the influx of
most compounds from blood to brain.
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Functions and Properties of the BBB
• Ions
• Amino Acids and organic acids
• Glucose and other carbohydrates
• Biogenic amines
• Nucleotide precursors
• Peptides, proteins and lipoproteins
• Steroid and thyroid hormones
• Vitamins, trace metals
• Chemotherapy agents, antibiotics
Transport at the BBB
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