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Endocrine Glands
Hormones
Can be divided into three groups
Amino acid derivatives
Peptide hormones
Lipid derivatives
Hormones
Endocrine Reflexes
Pituitary Gland
Figure 187 The Hypophyseal Portal System and the Blood Supply to
the Pituitary Gland.
Pituitary Gland
Pituitary Gland
Thyroid Gland
Consists of two lobes of endocrine tissue joined in middle by
narrow portion of gland
Follicular cells
Arranged into hollow spheres
Forms functional unit called a follicle
Lumen filled with colloid
Serves as extracellular storage site for thyroid hormone
C cells
Secrete peptide hormone calcitonin
Chapter 19 The Peripheral Endocrine Glands
Human Physiology by Lauralee Sherwood 2007 Brooks/Cole-Thomson Learning
Thyroid Gland
Thyroid Gland
Synthesis, storage, and secretion of thyroid hormone
Basic ingredients
Tyrosine
Synthesized in sufficient amounts by body
Iodine
Obtained from dietary intake
Synthesis
All steps occur on thyroglobulin molecules within colloid
Tyrosine-containing thyroglobulin is exported from follicular
cells into colloid by exocytosis
Thyroid captures iodine from blood and transfers it into
colloid by iodine pump
Within colloid, iodine attaches to tyrosine
Coupling process occurs between iodinated tyrosine
molecules to form thyroid hormones
Chapter 19 The Peripheral Endocrine Glands
Human Physiology by Lauralee Sherwood 2007 Brooks/Cole-Thomson Learning
Thyroid Gland
Storage
Thyroid hormones remain in colloid until they are split
off and secreted
Usually enough thyroid hormone stored to supply
bodys needs for several months
Secretion
Follicular cells phagocytize thyroglobulin-laden colloid
Process frees T3 and T4 to diffuse across plasma
membrane and into blood
Thyroid Gland
Effects of thyroid hormone
Main determinant of basal metabolic rate
Influences synthesis and degradation of
carbohydrate, fat, and protein
Increases target-cell responsiveness to
catecholamines
Increases heart rate and force of contraction
Essential for normal growth
Plays crucial role in normal development of
nervous system
Thyroid Gland
Secretion
Regulated by negative-feedback system between
hypothalamic TRH, anterior pituitary TSH, and
thyroid gland T3 and T4
Feedback loop maintains thyroid hormones
relatively constant
Regulation of Thyroid
Hormone Secretion
Thyroid Gland
Abnormalities
Hypothyroidism
Causes
Primary failure of thyroid gland
Secondary to a deficiency of TRH, TSH, or both
Inadequate dietary supply of iodine
Cretinism
Results from hypothyroidism from birth
Myxedema
Term often used for myxedema in adults
Treatment
Replacement therapy
Dietary iodine
Chapter 19 The Peripheral Endocrine Glands
Human Physiology by Lauralee Sherwood 2007 Brooks/Cole-Thomson Learning
Thyroid Gland
Abnormalities
Hyperthyroidism
Most common cause is Graves disease
Autoimmune disease
Body erroneously produces thyroid-stimulating
immunoglobulins (TSI)
Characterized by exopthalmos
Treatment
Surgical removal of a portion of the over-secreting thyroid
Administration of radioactive iodine
Use of antithyroid drugs
Adrenal Glands
Embedded above each kidney in a capsule of fat
Composed of two endocrine organs
Adrenal cortex
Outer portion
Secretes steroid hormones
Adrenal medulla
Inner portion
Secretes catecholamines
Adrenal Glands
Adrenal cortex
Consists of three layers or zones
Zona glomerulosa outermost layer
Zona fasciculata middle and largest portion
Zona reticularis innermost zone
Glucocorticoids
Primarily cortisol
Major role in glucose metabolism as well as in protein and lipid
metabolism
Sex hormones
Identical or similar to those produced by gonads
Most abundant and physiologically important is
dehydroepiandosterone (male sex hormone)
Chapter 19 The Peripheral Endocrine Glands
Human Physiology by Lauralee Sherwood 2007 Brooks/Cole-Thomson Learning
Adrenal Glands
Aldosterone
Principal action site is on distal and collecting
tubules of the kidney
Secretion is increased by
Activation of renin-angiotensin-aldosterone system by
factors related to a reduction in Na+ and a fall in blood
pressure
Direct stimulation of adrenal cortex by rise in plasma K+
concentration
Adrenal Glands
Cortisol
Stimulates hepatic gluconeogenesis
Inhibits glucose uptake and use by many tissues, but not
the brain
Stimulates protein degradation in many tissues, especially
muscle
Facilitates lipolysis
Plays key role in adaptation to stress
At pharmacological levels, can have anti-inflammatory and
immunosuppressive effects
Long-term use can result in unwanted side effects
Adrenal Glands
Secretes both male and female sex hormones in
both sexes
Dehydroepiandrosterone (DHEA)
Only adrenal sex hormone that has any biological
importance
Overpowered by testicular testosterone in males
Physiologically significant in females where it governs
Growth of pubic and axillary hair
Enhancement of pubertal growth spurt
Development and maintenance of female sex drive
Symptoms
Excessive Na+ retention and K+ depletion
High blood pressure
Newborn females
Have male-type external genitalia
Prepubertal males
Precocious pseudopuberty
Adult males
Has no apparent effect
Adrenal Medulla
Modified part of sympathetic nervous system
Primary stimulus for increased adrenomedullary secretion
activation of sympathetic nervous system by stress
Releases epinephrine and norepinephrine
Secreted into blood by exocytosis of chromaffin granules
Vary in their affinities for the different adrenergic receptor
types
Epinephrine
Reinforces sympathetic system in mounting general
systemic fight-or-flight responses
Maintenance of arterial blood pressure
Increases blood glucose and blood fatty acids
Stress Response
Pattern of reactions to a situation that threatens
homeostasis
Stress
Generalized nonspecific response of body to any
factor that overwhelms or threatens to overwhelm
the bodys ability to maintain homeostasis
Stressor
Any noxious stimulus that brings about the stress
response
Stress Response
All the actions are coordinated by the hypothalamus
Generalized stress response
Activation of sympathetic nervous system
accompanied by epinephrine secretion
Prepares body for fight-or-flight response
Catabolism
Breakdown or degradation of large, energy-rich organic
molecules within cells
Two levels of breakdown
Hydrolysis of large cellular molecules into smaller subunits
Oxidation of smaller subunits to yield energy for ATP
production
Chapter 19 The Peripheral Endocrine Glands
Human Physiology by Lauralee Sherwood 2007 Brooks/Cole-Thomson Learning
Metabolic States
Absorptive state
Fed state
Glucose is plentiful and
serves as major energy
source
Postabsorptive state
Fasting state
Endogenous energy
stores are mobilized to
provide energy
Pancreatic Hormones
Pancreas
Endocrine cells Islets of Langerhans
(beta) cells
Site of insulin synthesis and secretion
(alpha) cells
Produce glucagon
D (delta) cells
Pancreatic site of somatostatin synthesis
PP cells
Least common islet cells
Secrete pancreatic polypeptide
Pancreatic Hormones
Somatostatin
Released from pancreatic D cells in direct
response to increase in blood sugar and blood
amino acids during absorption of a meal
Prevents excessive plasma levels of nutrients
Local presence of somatostatin decreases
secretion of insulin, glucagon, and somatostatin
itself
Physiologic importance has not been determined
Pancreatic Hormones
Insulin
Anabolic hormone
Promotes cellular uptake of glucose, fatty acids,
and amino acids and enhances their conversion
into glycogen, triglycerides, and proteins,
respectively
Lowers blood concentration of these small organic
molecules
Pancreas
Diabetes Mellitus
Most common of all endocrine disorders
Prominent feature is elevated blood glucose levels
Urine acquires sweetness from excess blood
glucose that spills into urine
Two major types
Type I diabetes
Characterized by lack of insulin secretion
Type II diabetes
Characterized by normal or even increased insulin
secretion but reduced sensitivity of insulins target cells
Acute Effects
of
Diabetes Mellitus
Pancreatic Hormones
Glucagon
Mobilizes energy-rich molecules from storage
sites during postabsorptive state
Secreted in response to a direct effect of a fall in
blood glucose on pancreatic cells
Generally opposes actions of insulin
No known clinical abnormalities caused by
glucagon deficiency or excess
Excess of glucose can aggravate hyperglycemia of
diabetes mellitus
Hypercalcemia
Reduces excitability
Hypocalcemia
Brings about overexcitability of nerves and muscles
Severe overexcitability can cause fatal spastic contractions of
respiratory muscles
Parathyroid Glands
Calcium Disorders
PTH hypersecretion (hyperparathyroidism)
Characterized by hypercalcemia and
hypophosphatemia
PTH hyposecretion (hypoparathyroidism)
Characterized by hypocalcemia and
hyperphosphatemia
Vitamin D deficiency
Children rickets
Adults osteomalacia