THE PHILOSOPHY OF SCIENCE

THE HUMAN BEING

AS THE UNITY OF
BIOPSYCHOSOCIAL

FROM PHYSICAL POINT OF VIEW, THE GENESIS OF

OF THOSE EXIXTENCIES, BASED ON TRIAS
EXISTENTIALISM
1. THE BIG CREATION
THE CREATION OF BILLION LAWS OF
PHYSICS
2. THE BIG BANG
THE CONSEQUENCY OF ACTIVATION
OF THE LAWS OF PHYSICS
( GRAVITATION & DIESEL LAWS )
3. THE BIG CRUNCH
THE CONSEQUENCY OF BILLION LAWS OF
PHYSICS (GRAVITATION LAWS) RECYCLING
MECHANISM OF THE BIG BANG AND
THE BIG CRUNCH LEADS TO ETERNITY

THE LAW OF
GRAVITATION
LEADING TO
DENTIFICATION
OF ENERGY AND
CRITICAL
DENSITY OF
ENERGY LEADING
TO EXPLOSE

NAMELY THE BIG

BANG

SCIENTIFIC SYSTEM :
a. THE PHILOSOPHY OF SCIENCE
b. THE ONTOLOGY. EPISTEMOLOGY, THE AUXIOLOGY
C. STRUGGLE FOR SURVIVAL OF THE DISCIPLINE OF
SCIENCE
1, THE THEORITICAL SCIENCE
a. NOMOTHETIC THEORITICAL SCIENCE
b. DESCRIPTIVE THEORITICAL SCIENCE

2. THE APPLIED SCIENCE

a. NORMATIVE APPLIED SCIENCE
b. TELEOLOGIC APPLIED SCIENCE

c. COMPREHENSIVE APPLIED SCIENCE

d. FINALISTIC APPLIED SCIENCE
e. COMPLEMENTARY APPLIED SCIENCE
3. PROFESSIONALISM

(ETHICS, POSTULATE, PARADIGMA)

HEALTH SCIENCE IS ALWAYS BASED

ON FUNDAMENTAL TRUTH CALLED
POSTULAT
1. THE BIO-ORGANIC POSTULATE
(BEFORE 1950)
2. THE BIOCELLULARY POSTULATE
(1950 - 2000)
3. THE BIOMOLECULARY POSTLATE
(AFTER 2000 CALLED THE THIRD
MELLINNEUM)

Bio-organic postulate
1.INTERDEPENDENCY
ORGANON

organon
organon

2.Feed back mechanism

3.Equilibrium

organon

organon

Biocellulary postulate
The second millenium : The naumena

of life
The cell
The tissue

organ

Central coordination :
Diencephalon (Thalamus,
hypophyse, hypothalamus,

mitochondria

The gap junction,

100 Ang

The cell
The receptor (15.000)

Endoplasmic
nucleus reticula in
cytoplasma
150.000
Mitocho
dria

ribosome

Apparatus Golgi
Lysosome Centrosome

The component

p
: BIOMOLECULARY POSTULATE
The third millrnnium

Life is indeed the mechanic biological

process, within the self propelling biochemistry reaction leading to have the
effect of
1. Growth mechanism,
2. Reproduction
3. Differentiation
4. Evolution

POSTULATIC BACKGROUND :
The changing postulate

1. Bio-organic
2. Biocellular
3. Biomolecular
overlapping
bioorganic

Biocellular

TELEOLOGIC

T
PARADIGMA

E
L
E
area O
L
O
G
Biomolecular
I
C

1.METALOPROTEINASE I
a. Angiopoetin for capillary bed
b. vasculopoetin for vascularity

THE CELL

2. METALOPROTEINASE II
For nutritional cytocine

3. METALOPROTEINASE III
For extracellulary matrix (ECM))

22.P.72

a. For the frame of ECM ( collagen, elastin,

fibroprotein

22.P.92

b. For the basic ontent uf spaces of the frame

( mucopolysacharide fluid )
c. For the substances supporting the living cell
( GAG, laminin, nutrition, mineral,
aminoglican, hyalin, etc )
4. METALOPROTEINASE IV
For protocollagenase and proto stromelysin

(active after contact with the proteinase enzym

THE INTERDEPENDENCY
THE CELL
GAP-JUNCTION
200 ANGSTROM

RECEPTOR c-AMP

THE ECM
RECEPTOR c-GMP

THE ACTIN MECHNISM

THE INTEGRIN MECHANISM
THE CMPONENT

The postulate of science

1. Bio-organic postulate
2. Biocellular postulate
3. Biomolecular postulate

1.
2.
3.
4.

Nucleus
Mitochondria
Ribosoma=
Apparatus
Golgi
5. Centrosoma
6. Lysosoma

THE INTERDEPENDENCY
THE CELL
GAP-JUNCTION
200 ANGSTROM

RECEPTOR c-AMP

THE ECM
RECEPTOR c-GMP

THE ACTIN MECHNISM

THE INTEGRIN MECHANISM
THE CMPONENT

At-1R
A
t

At-2R

Endothel
ia

Nutritional Nutrition for the cell

Cytokin
22.p.72

The cell

The fourth fundamental

physical law of nature :
interdependency

ENDOTHELIAL DYSFUNCTION
Endothelin
At-1RAdhesion mol

NO
Ar-2R
Prostacyclin
component

C-AMP
C-Amp
Ca+
Oligopeptide
Oligosachaeride

C-DNA
nucleus

A-Gmp
Ca+
Oligopeptide
Oligosacharide

Endothelium
Nutrition receptor

ENDOTHELIAL RECEPTOR

At-1 R
1.Chol:HDL

A-2R

2. LDL:HDL
1.Atorvastatin
3. LDL:Apo B
2. imidapri
4.Glucose > 150
3. Glycine
5. Oxidant:Antioxidant
4. acethyl choline
6. Ion Ca
5.Miranda citrofolia
7. Homocystein
6.L-Arginin
8. Mt-DNA:c-DNA
9. Auto-immune
10.Hs-CRP
11.Central hormonal/
periphery hormonal
12.Angiotensin II
13.Infected vasculitis
14.Smoking
15.psychogenic distress
16 Ionizing radiation
17. Degeneration process

Ar-3R

At-4R

nutrition R
Cell 22.p.72 et 92
produces
nutrition cytokine

captured by
the endothelial
nutritional recep
tor

reprogramming
of the endothelia
,

pinocytosis, cooking,
extracellularization

STEM CELL PROBLEMS

TECHNOLOGY FOR REPAIRY
MECHANISM BY CELL
TRANSPLANTATION FOR THE
DESTROYED IN VIVO CELLS /
TISSUE / ORGAN

Pleuripotent stem cell

Embryonal stem cell

gastrula
stage
Conception
Conception
ovum
ovum

Omnipotent stem cell

Fat tissue
aspiration

Morula
stage

Blastula
stage

Adult stem cell

1.Blood cell
2. Muscle cell
3..liver cell
4. Nerve cell etc

centrifused
1.

Medulla osseum 4 blood cell

2.

Umbillicus cell

5.muscle cell

3.

Syncitium cell

6. nerve cell

syncitium
7. liver cell

Parkinson therapy by cell transplantation

for producing dopamin

FROM WHERE YOU WILL SEE THOSE SCIENTIFIC

The philosophical outlook

DEVELOPMENTS

1. Availibelity
2. Proliferation
3. Defferentiation
4. Complication
a. teratoma
b. tumor
5. Ethical concern

1. Unprocess stem-cell
2. Expanded cell line
3. Defferentiation to
precussor cell

Some new drugs in cell manipulations

1. FGF-1 for skin cell regeneration
2. Cartidea, glucos amino glycan for ECM
(oral approach)
3. VEGF for recovery of endothelial
dysfunction
4. Sino thymus
sino cytokin
Sino serum
5. Sino embryo
sino regenes
Sino eregenes
6. 28 micro-peptides ( available now )

The nucleus

22p72
22p92

the cell
4. Protocollagenase &
Protostromelycin
protease

Cartidea /
Metalloproteinase
1,2,3,4
GAG

1. Angiopoetin & vasculopoetin

2. Communication & socialization
(cytokine)
3. For building the health ECM
a. The frame (fibroprotein,
collagen, elastin, fibronectin etc)
b. Fluid filling the space built
by rhe frames
(mucopolysaccharide)
c. The conten in the fluidy
mucopolysaccharide
4. for proto collagenase &
protostrmelysin

Inflammation
Ag

immune reaction

Pro inflammatory Il ;
Anti-inflammatory Il
1. Il-1 beta
1. Il-1 alpha
2. Il-2
2. Il-4
3. Il-6
3. Il-10
4. Il-8
Pro inflammatory vaso-active
amine ;
1. prostaglandin
Tgf-alpha
2. anaphylatoxin

ERYTHROPOETIN

IL-2 ,IL-3

THROMBOPOETIN
LEUCOPOETIN

L-T

L-Th
L-Ts
L-Tk
L-Tm

LEOCOCYTE
EOSINOPYL
BASOPHYL
NEUTRPHYL
LYMPHOCYTE
MONOCYTE

L-B
MEDULLA SPINALIS
ERYTHROPOETIC ORGAN
THROMBOPOETIC ORGAN
LEUCOPOETIC ORGAN

Eosinophyl leucopoetin
Basophyl leucopoetin
Neutrophyl leucopoetin
Lymphocyte leucopoetin /
Lymphopoetin

Monocyte leucopoetin