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CYCLE
INTRODUCTION
STEPS IN UREA
CYCLE
2. FORMATION OF CITRULLINE
3. SYNTHESIS OF ARGININOSUCCCINATE :
4. CLEAVAGE OF
ARGININOSUCCINATE :
Argininosuccinate cleaved by
argininosuccinate lyase to yield
arginine and fumarate.
The arginine formed by this reaction
serves as the immediate precursor of
urea.
Fumarate produced in the urea cycle is
hydrated to malate, -fumarate that librated here
provides a connecting link with TCA cycle and
gluconeogenesis.(see later)
5. FORMATION OF UREA :
Glutamine-
Amines-
- 4 ATP
+10 ATP
H2 O
CO2
CO2