Professional Documents
Culture Documents
Today
Lecture (Fox and Clauss/Blackford
papers)
Focus on the BI phenotype and its
association with mental health,
especially social anxiety disorder
(SAD)
PSYC 210:
How does N/NE contribute to emotional disorders?
Part 2 of 3
Focus on Behavioral Inhibition (BI) and Social Anxiety Disorder
AJ Shackman
14 April 2015
What is BI?
Intuitive Feel
http://
www.abc.net.au/tv/life/video/LIFEAT1.
BI in Toddlers
Passive Avoidance / Freezing
Avoid unfamiliar events, objects (robot) and
people (intruder)
When faced with such challenges, children
with high levels of BI cease their play,
become quiet, and withdraw to the proximity
of their caregivers
BI in Toddlers
Passive Avoidance / Freezing
Avoid unfamiliar events, objects (robot) and
people (intruder)
When faced with such challenges, children
with high levels of BI cease their play,
become quiet, and withdraw to the proximity
of their caregivers
Retrospectively Assessing BI in
Adults
Reznick and colleagues RSRI
Were you afraid of unfamiliar animals, such as
those you encountered on the street or at
someone elses home?
Did it upset you when your parents left you with a
new, unfamiliar baby-sitter?
Did you ever pretend to be sick in order to avoid
going to school or to other social events?
Did you enjoy meeting new children your age?
Retrospectively Assessing BI in
Adults
Reznick and colleagues RSRI
Were you afraid of unfamiliar animals, such as
those you encountered on the street or at
someone elses home?
Did it upset you when your parents left you with a
new, unfamiliar baby-sitter?
Did you ever pretend to be sick in order to avoid
going to school or to other social events?
Did you enjoy meeting new children your age?
Retrospectively Assessing BI in
Adults
Reznick and colleagues RSRI
Were you afraid of unfamiliar animals, such as
those you encountered on the street or at
someone elses home?
Students: Why
would you want to
Did it upset you when your parents left you with a
assess BI
new, unfamiliar baby-sitter?
via adult selfreport?
Did you ever pretend to be sick in order to avoid
going to school or to other social events?
Did you enjoy meeting new children your age?
Retrospectively Assessing BI in
Adults
Reznick and colleagues RSRI
Were you afraid of unfamiliar animals, such as
those you encountered on the street or at
someone elses home?
Usual
Caveats
About
Did it upset
you whenSelfyour parents left you with a
new, unfamiliar baby-sitter?
Report
Measures
Did you ever
pretend to be sick in order to avoid
going to schoolApply
or to other social events?
Did you enjoy meeting new children your age?
BI in Toddlers
Passive Avoidance / Freezing
They remain vigilant (orient toward source of potential
threat)
May show high levels of distress (reactive) or show
elevated levels of the stress hormone cortisol
Parallels with AT in monkeys (freezing/cortisol) and BIS
(passive avoidance) in adults
BI is a Facet of N/NE
BI in Toddlers
Students
Show of hands, how many of you had some kind of strong fear or anxiety when you were little that you
grew out of
(e.g., strangers, losing your parents, getting lost, monsters, etc.)
Students
Modest Continuity
Reflects Heterogeneity
Fears are thought to be protective, preventing
the child from encountering harm during
periods marked by the onset of walking and
increased exploration
For most kids, the normative fears vanish by 23 years
Modest Continuity
Reflects Heterogeneity
Fears are thought to be protective, preventing
the child from encountering harm during
periods marked by the onset of walking and
increased exploration
For most kids, the normative fears vanish by 23 years
Modest Continuity
Reflects Heterogeneity
But for some kids, childhood is marked by the
persistence of these fears and the
development of new fears, which we would
deem non-normative or age-inappropriate (i.e.,
clinically significant)
Modest Continuity
Reflects Heterogeneity
But for some kids, childhood is marked by the
persistence of these fears and the
development of new fears, which we would
deem non-normative or age-inappropriate (i.e.,
clinically significant)
Modest continuity of BI partially reflects
heterogeneity in the functional significance of
early-life anxiety and inhibition; for some kids,
its a normal part of growing up; for others, a
harbinger of life-long challenges
Modest Continuity
Reflects Heterogeneity
But for some kids, childhood is marked by the
persistence of these fears and the development of
new fears, which we would deem non-normative or
age-inappropriate (i.e., clinically significant)
Modest continuity of BI partially reflects
heterogeneity in the functional significance of earlylife anxiety and inhibition; for some kids, its a
normal part of growing up; for others, a harbinger of
life-long challenges
It also reflects the emergence/maturation of emotion
regulation
confers
liability for Social Anxiety
Disorder (SAD)
MTV Perspective
http://www.mtv.com/videos/true-life-i-have-social-
NIMH Perspective
http://www.nimh.nih.gov/health/topics/social-phobia-social-anxiety-
http://www.nimh.nih.gov/health/topics/social-phobia-social-anxiety-
http://www.nimh.nih.gov/health/topics/social-phobia-social-anxiety-
http://www.nimh.nih.gov/health/topics/social-phobia-social-anxiety-
http://www.nimh.nih.gov/health/topics/social-phobia-social-anxiety-
http://www.nimh.nih.gov/health/topics/social-phobia-social-anxiety-
http://www.nimh.nih.gov/health/topics/social-phobia-social-anxiety-
http://www.nimh.nih.gov/health/topics/social-phobia-social-anxiety-
Bottom Line:
Convergence between the social reticence of extreme BI and
SAD
Students?
What might explain this trajectory?
That is, how does BI become adult
dysfunction?
Quick Recap
Available @
http://
www.sciencedirect.com/science/article/pii/S00057967140006
06
In the second half of the paper, they describe several case
studies of individual patients (e.g. Deandres experience
with social phobia).
Read one or more of the vignettes and comment on what you
found most interesting and, as relevant, how it relates to the
Available @
http://
www.sciencedirect.com/science/article/pii/S00057967140006
06
In the second half of the paper, they describe several case
studies of individual patients (e.g. Deandres experience
with social phobia).
Read one or more of the vignettes and comment on what you
found most interesting and, as relevant, how it relates to the
Available @
http://
www.sciencedirect.com/science/article/pii/S00057967140006
06
In the second half of the paper, they describe several case
studies of individual patients (e.g. Deandres experience
with social phobia).
Read one or more of the vignettes and comment on what you
found most interesting and, as relevant, how it relates to the
Time-Permitting
Review Questions
Which is true?
A. There is one
anxiety disorder
B. There is a whole
family of
anxiety
disorders
A. N/NE and a
disorder-specific
learned
vulnerability (e.g.,
fear dogs)
B. N/NE and an innate
vulnerability
C. N/NE and other
non-specific risk
factors
N/NE is a
A. Cause of emotional
disorders
B. Symptom of
emotional disorders
C. Identical to or
synonymous with
the emotional
disorders
D. A symptom of too
much anxiety
The End
Extra Slides
Genome (Genotype)
Endophenotypes: 6 Criteria
http://www.nimh.nih.gov/health/topics/social-phobia-social-anxiety-
http://www.nimh.nih.gov/health/topics/social-phobia-social-anxiety-