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Definition
A quantitative Bence-Jones protein test
measures the specific level of abnormal
proteins (Bence-Jones proteins) in your
urine
Alternative Names
Immunoglobulin light chains - urine;
Urine Bence-Jones protein
Normal Results
A normal result means no Bence-Jones
proteins are found in your urine.
What Abnormal Results Mean
Bence-Jones proteins are rarely found in
urine. If they are, it is usually associated
with multiple myeloma.
An abnormal result may also be due to
Waldenstrom's macroglobulinemia, chronic
lymphocytic leukemia, or amyloidosis.
amyloidosis
Considerations
Urine immunofixation is the best test for
detecting Bence-Jones proteins
test
Normal
Negative
Positive
Amyloidosis (primary), benign monoclonal
gammopathy, cryoglobulinemia, Fanconi
syndrome (adult), hyperparathyroidism,
multiple myeloma (high levels indicate
poor prognosis), osteomalacia, and
Waldenstrm's macroglobulinemia.
macroglobulinemia
A low-molecular-weight, light-chain
immunoglobulin synthesized by malignant
plasma cells in the bone marrow and
initially broken down and reabsorbed by
the kidneys.
Preparation
Obtain a clean specimen container without
preservatives
Procedure
Obtain a 25-mL first morning-voided,
random urine specimen in a clean
container. A fresh specimen may be taken
from a urinary drainage bag.
Postprocedure Care
Send the specimen to the laboratory and
refrigerate.
Sabah eid
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