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Blood
The only fluid tissue in the
human body
Classified as a connective tissue
Living cells = formed elements
Non-living matrix = plasma
Protection.
Regulation
Blood Plasma
Composed of approximately 90 percent water
Includes many dissolved substances
Nutrients
Salts (metal ions)
Respiratory gases
Hormones
Proteins
Waste products
Plasma Proteins
Albumin regulates osmotic pressure
Clotting proteins help to stem blood loss
when a blood vessel is injured
Antibodies help protect the body from
antigens
Formed Elements
Erythrocytes = red blood cells
Leukocytes = white blood cells
Platelets = cell fragments
Figure 10.2
Blastocyst
Hemopoiesis
Adult produces 400 billion platelets, 200 billion RBCs and
10 billion WBCs every day
Hemopoietic tissues produce blood cells
yolk sac produces stem cells
colonize fetal bone marrow, liver, spleen and thymus
Hematopoiesis
Leukocyte Terms
Leukocytosis- A rise in production of WBC
count, usually due to response to infection.
Leukopenia- Abnormally Low WBC count
Types of Leukocytes
Granulocytes
Granules in their
cytoplasm can be
stained
Include neutrophils,
eosinophils, and
basophils
Figure 10.4
Eosinophiles
Function: Phagocytosis of
antigen-antibody
complexes; allergens
Release enzymes to weaken
or destroy parasites such as
worms.
Appearance: Nuceus has 2
large lobes
Basophil
Appearance:
Function: Secretes
Histamine,( a
vasodilator)
Secretes heparin ( an
anticoagulant)
Neutrophils
Appearance
Nucleus usually with 35 lobes in S-C shaped
array
Functions:
Phagocytosis of bacteria
Release of antimicrobial
chemicals
Agranulocytes
Lymphocytes
Nucleus fills most of the cell
Play an important role in the immune response
Monocytes
Largest of the white blood cells
Function as macrophages
Important in fighting chronic infection
Lymphocytes
These are cells involved in the..
IMMUNE RESPONSE
There are: B-Lymphocytes
and
T-Lymphocytes
Monocytes
Largest of the WBCs
They resemble lymphocytes
however they contain much
more cytoplasm.
They are macrophages.
Granulocyte Functions
Neutrophils ( in bacterial infections)
phagocytosis of bacteria
release antimicrobial chemicals
Hemoglobin
Iron-containing protein
Binds strongly, but reversibly, to
oxygen
Each hemoglobin molecule has four
oxygen binding sites
Each erythrocyte has 250 million
hemoglobin molecules
Hemoglobin
Control of Erythrocyte
Production: Homeostasis
Figure 10.5
Fate of Erythrocytes
Unable to divide, grow, or
synthesize proteins
Wear out in 100 to 120 days
When worn out, are eliminated by
phagocytes in the spleen or liver
Lost cells are replaced by division
of hemocytoblasts
Stop
Destruction of RBCs
Macrophages phagocytize and destroy damaged
RBCs primarily in the liver and the spleen.
Subunits are HEME, the iron-containing portion
and globin, the protein.
The hemo further decomposes into biliverdin which
decomposes into bilirubin (orange)---excreted in
Bile.
Fe returns to hematopoietic tissue for reuse.
SUBSTITUTION MUTATION
Hematocrit
When analyzing blood the 3 most important measurements
are RBC count, hemoglobin concentration and Hematocrit.
Hematocrit stands for total blood volume.
Usually 4.6 -6.2 million RBCs / uL in men
4.2 -5.2 million RBCs / uL in women
Why the difference?
What is Hemostasis?
This is the stoppage of bleeding
Important when blood vessels are damaged
to prevent excessive blood loss.
Hemostasis includes: blood vessel spasm,
platelet plug formation and blood
coagulation(Formation of a clot)
Platelets (Thrombocytes)
Derived from ruptured multinucleate cells
(megakaryocytes)
Needed for the clotting process
Normal platelet count = 300,000/mm3
Undesirable Clotting
Thrombus
A clot in an unbroken blood vessel
Can be deadly in areas like the heart
Embolus
A thrombus that breaks away and floats freely in
the bloodstream
Can later clog vessels in critical areas such as the
brain
Agglutination of Erythrocytes
Antibodies
secreted by plasma cells
as part of immune response to foreign matter
Agglutination
antibody molecule binding to antigens
causes clumping
ABO
Group
Your ABO blood type is determined by presence
or absence of antigens (agglutinogens) on RBCs
Rh
Group
Rh (D) agglutinogens discovered in rhesus
monkey in 1940
Rh+ blood type has D agglutinogens on RBCs
Rh frequencies vary among ethnic groups
RH Factor