Professional Documents
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Chapter 4
Dr Fadel Naim
Ass. Prof. Faculty of Medicine
IUG
Body Membranes
Thin tissue layers that cover surfaces, line cavities,
and divide spaces or organs
Epithelial membranes are most common type
Cutaneous membrane (skin)
Primary organ of integumentary system
One of the most important organs
Composes approximately 16% of body weight
Body Membranes
Mucous membrane (mucosa)
Lines and protects organs that open to the exterior of the body
Found lining ducts and passageways of respiratory, digestive, other
tracts
Lamina propriafibrous connective tissue underlying mucous
epithelium
Mucus is made up mostly of water and mucinsproteoglycans that
form a double-layer protection against environmental microbes
Serous Membranes
Anatomy of Skin
Slide 6
Functions of Skin
Function of Integumentary System
A. Regulation of Body Temperature
B. Protection from Dehydration and Infection
C. Respond to Temperature, Pressure, Pain
D. Excretion of Water, Salts, Urea (nitrogenous waste)
E. Synthesis Vitamin D (essential for Ca + P absorption)
F. First Defensive Barrier of Immune Response
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Excretion
Water
Urea/ammonia/uric acid
Slide 10
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Layers of Skin
Epidermis
Dermis
Subcutaneous layer
beneath dermis
not part of skin
Epidermis
Lacks blood vessels
Keratinized
Thickest on palms and soles (0.8-1.4mm)
Melanocytes provide melanin
Rests on basement membrane
Stratified squamous
Epidermis
Layers of Epidermis
stratum corneum
stratum lucidum
stratum granulosum
stratum spinosum
stratum basale
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Dermis
On average 1.0-2.0mm thick
Contains dermal papillae
Binds epidermis to underlying tissues
Irregular dense connective tissue
Muscle cells
Nerve cell processes
Specialized sensory receptors
Blood vessels
Hair follicles
Glands
Slide 24
Lines of Cleavage
Tension lines in the skin identify the predominant
orientation of collagen fiber bundles.
Clinically and surgically significant because cuts
can result in slow healing and increased
scarring.
Slide 28
Subcutaneous Layer
hypodermis
loose connective tissue
adipose tissue
insulates
major blood vessels
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Slide 31
Skin Color
Genetic Factors
Physiological Factors
varying amounts of
dilation of dermal blood
melanin
vessels
varying size of melanin
constriction of dermal blood
granules
vessels
albinos lack melanin
accumulation of carotene
jaundice
Environmental Factors
sunlight
UV light from sunlamps
X rays
darkens melanin
Skin Color
Melanin
Basic determinant of skin color is quantity, type, and distribution of
melanin
Beta carotene
(group of yellowish pigments from food) can also contribute to skin
color
Hemoglobin
color changes also occur as a result of changes in blood flow
Redder skin color when blood flow to skin increases
Cyanosisbluish color caused by darkening of hemoglobin when
it loses oxygen and gains carbon dioxide (Figure 6-9)
Bruising can cause a rainbow of different colors to appear in the
skin
Other pigments
from cosmetics, tattoos, and bile pigments in jaundice
Slide 33
Cyanosis
bluish color to nail beds and skin
hemoglobin depleted of oxygen looks purple-blue
Erythema
redness of skin due to enlargement of capillaries in dermis
during inflammation, infection, allergy or burns
Slide 34
Skin glands
Sebaceous glands
Secrete sebumoily substance that keeps hair and skin
soft and pliant; prevents excessive water loss from the
skin
usually associated with hair follicles
Lipid components have antifungal activity
Simple, branched glands
Found in dermis except in palms and soles
Secretion increases in adolescence; may lead to
formation of pimples and blackheads
Slide 35
Sweat Glands
Widespread in skin
Originates in deeper dermis
Or hypodermis
Eccrine glands
Apocrine glands
Ceruminous glands
Mammary glands
Sweat glands
Eccrine glands
Most numerous sweat glands; quite small
Distributed over total body surface with
exception of a few small areas
Simple, coiled, tubular glands
Function throughout life
Secrete perspiration or sweat; eliminate
wastes; and help maintain a constant core
temperature
Slide 37
Sweat glands
Apocrine glands
Located deep in subcutaneous layer
Limited distributionaxilla, areola of breast,
and around anus
Large (often more than 5 mm in diameter)
Simple, branched, tubular glands
Begin to function at puberty
Secretion shows cyclic changes in female
with menstrual cycle
Slide 38
Sweat glands
Ceruminous glands
Hair
Distributionover entire body except
palms of hands and soles of feet and a
few other small areas
Fine and soft hair coat present before birth called
lanugo
Coarse pubic and axillary hair that develops at
puberty called terminal hair
Slide 40
Functions of Hair
Protection
Heat retention
Prevents the loss of conducted heat from the
scalp to the surrounding air
Facial expression
Sensory reception
Visual identification
Chemical signal dispersal
Hair Follicles
Epidermal cells
Tube-like depression
Extends into dermis
Hair root
Hair shaft
Hair papilla
Dead epidermal cells
Melanin
Arrector pili muscle
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Appearance of hair
Color
result of different amounts, distribution, types of melanin in
cortex of hair
Growth
hair growth and rest periods alternate; hair on head averages 5
inches of growth per year
Sebaceous glands
attach to and secrete sebum
(skin oil) into follicle
Slide 47
Nails
Consist of epidermal cells
converted to hard keratin
Nail bodyvisible part of
each nail
Rootpart of nail in groove
hidden by fold of skin, the
cuticle
Lunulamoon-shaped
white area nearest root
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Burns
Tissue damage from excessive heat, electricity, radioactivity,
or corrosive chemicals that destroys (denatures) proteins in
the exposed cells is called a burn.
Generally, the systemic effects of a burn are a greater threat
to life than are the local effects.
The seriousness of a burn is determined by
Its depth
Extent
Area involved
The persons age and general health.
When the burn area exceeds 70%, over half of the victims die
Slide 51
Burns
Destruction of proteins of the skin
chemicals, electricity, heat
Slide 52
Types of Burns
First-degree
only epidermis (sunburn)
Slide 53
Types of Burns
Second-degree burn
Slide 54
Types of Burns
Third-degree or full-thickness
destroy epidermis, dermis & epidermal derivatives
damaged area is numb due to loss of sensory nerves
Slide 55
Rule of Nines
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SkinandAgingProcess
Skin Cancer
The most common type of cancer.
The greatest risk factor is exposure to UV
rays of the sun.
The highest incidence is in people who
have had severe sunburns, especially as
children.
Skin Cancer
Most skin tumors are benign and do not
metastasize
The three major types of skin cancer are:
Basal cell carcinoma
Squamous cell carcinoma
Melanoma
Melanoma
Cancer of melanocytes is the most dangerous type
of skin cancer because it is:
Highly metastatic
Resistant to chemotherapy
Melanoma
Melanomas have these characteristics (ABCD
rule)
A: Asymmetry; the two sides of the pigmented area
do not match
B: Border is irregular and exhibits indentations
C: Color (pigmented area) is black, brown, tan, and
sometimes red or blue
D: Diameter is larger than 6 mm (size of a pencil
eraser)
Melanoma
Treated by wide surgical excision
accompanied by immunotherapy
Chance of survival is poor if the lesion is
over 4 mm thick
THE END