HUMAN DISEASE

DETECTION
ARCHITECTURE USING
DIP&ANN
PROJECT GUIDE
Mrs. M.JENATH M.E .,AP/ECE
PROJECT MEMBERS
G.R.PRIYADHARSHINI 420412106073
V.SUSITHRA
R.NAFSIN
M.THARAGESHWARI

Genes and genetic mutation

Basic physical and functional unit of heredity.
made up of DNA, act as instructions to
make molecules called proteins.
vary in size from a few hundred DNA bases to
more than 2 million bases
GENETIC MUTATION
Misspelling of genes,
Is a permanent change of
the nucleotide
sequence of the DNAor other genetic
elements.

What does genetic mutation leads

to?
Genetic mutation leads to disorders in humans
E.g. :all types of cancers, polycystic kidney
disease, autism, colorblindness, goiter deafness,
diabetes, MERS and
so
on..

DNA Microarray
DNA Microarray:
Its a bio chip which can store millions
of DNA experimental genes and
reference genes DNA Microarray
procedure.
Disease probing is done by Adaptive genetic algo

PRESENT SYSTEM

LIMITATIONS OF THE EXISTING

SYSTEM
The major limitations are:
Used only for detecting diseases in infants
Doesnt include the changes in surroundings which is more
related to the emergence of disease
Doesnt rely on the changes in DNA over time
In order to overcome the above limitations, a new
system is proposed which includes:
Architecture for predicting diseases for all human beings .
Diseases which are caused due to change in surroundings,
habits and stress levels in people can also be found
Change in DNA over time can be found out and proper
treatment is given to people for prevention.

PROPOSED SYSTEM

CONCLUSION
In the proposed architecture, two hidden
layers are used in artificial neural
networks.
Image segmentation method used is
Adaptive ellipse method.
Using this architecture, we can the predict
the probability of disease and disorder in
humans

REFERENCES
[1] Sathish Kumar.S., and N. Duraipandian., "An Effective
Identification of
Species from DNA Sequence: A Classification Technique by
Integrating
DM and ANN.", International Journal of Advanced Computer Science
and Applications, Vol. 3, No.8, 2012.
[2] Khan, Omniyah Gul M., et al., "DNA base-calling using
artificial neural
networks.", Biomedical Engineering (MECBME), 2011 1st Middle East
Conference on. IEEE, 2011.
[3] Kim, Kyung-Joong, and Sung-Bae Cho., "Evolving
artificial neural
networks for DNA microarray analysis.", Evolutionary Computation,
2003. CEC'03. The 2003 Congress on. Vol. 4. IEEE, 2003.
[4] Fitch, J. Patrick, and Bahrad Sokhansanj., "Genomic
engineering:
moving beyond DNA sequence to function.", Proceedings of the IEEE
2000.
[5] Elhadi, Gamal F., R. M. Farouk, and Abdalhakeem T.
Issa., "Protein
sequence for clustering DNA based on Artificial Neural Networks.",

[7] Molla, Michael, et al., "Using machine learning to

design and interpret
gene-expression microarrays.", AI Magazine, 2004.
[8] Mry, Tarik., "DNA Microarrays in Medicine: Can the
Promises Be
Kept?.", Journal of Biomedicine and Biotechnology, 2002.
[9] Hewett, Rattikorn, and Phongphun Kijsanayothin.
"Tumor classification
ranking from microarray data.", BMC genomics, 2008.
[10] Zhao, Xin, and Leo WK Cheung.,"Kernel-imbedded
Gaussian processes
for disease classification using microarray gene expression data.",
BMC
bioinformatics, 2007.
[11] Beiko, Robert G., and Robert L. Charlebois., "GANN:
genetic algorithm
neural networks for the detection of conserved combinations of
features
in DNA.", BMC bioinformatics, 2005.
[12] Lee, Chien-Pang, et al., "Gene selection and sample
classification on
microarray data based on adaptive genetic algorithm/k-nearest