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Melinda Ong
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Yoel Tanuwijaya
Immune system
The immune system : collection of cells,
Innate imunity
innate immune system: cells and proteins that are
1. Physical epithelial
barrier
Epitelial of the skin, respiratory tract, GI tract
Mechanism:
antimicrobial enzyme lyzozime digest cell
wall
Antimicrobial peptide defensin, cathelicidin,
hisatatins cell membrane
Tight junction between cell
Mucus secretion
Stomach acid acidic ph
Peristaltic
Physical barrier
destroy
Produce antimicrobial protein
cytokine
Machropage cyokine that
stimulate inflammation
causing: capillary dilation,
increase blood flow
Macrophage n DC APC
activate adaptive
3. Dendritic cells
Phagositing microbe that passs through the
epitelial barrier
Express receptor (TLR) that recognize microbe
(PAMP) produce cytokine
Major cell type that capture and display
antigens to T-cell
Link between innate & adaptive
4.Plasma protein
Many circulating protein bind microbes and
lymphocite precursor
But express the receptor that bind
to general bacterial/viral antigen.
Than spesific peptide sequence
Activating receptor to detect
stressed/infected cell with DNA
damage kill them
Produce: macrophage-activating
cytokine IFN-
Adaptive immunity
adaptive immune system, on the other hand, is
1. T-Lymphocye
Thymus-derived lymphocyte
Major population in spleen & peripheral lymp nodes
T cell are only able to recognize peptide fragment
B-lymphocyte
Bone marrow-derived lymphocyte
10-20%- peripheral lymphocytes , bone
POSITIVE
POSITIVE
SELECTION
SELECTION
AND
AND NEGATIVE
NEGATIVE
SELECTION
SELECTION
B
B CELL
CELL
RECEPTOR
(BCR)
(BCR)
ANTIGEN
ANTIGEN
PRESENTING
PRESENTING
CELL
CELL
BONE
BONE MARROW
SYNTHESIS OF B CELL
B CELL DEVELOPMENT
B CELL DEVELOPMENT
BCR enables the cell to bind and, if additional signals are presents, to be
activated by and respond to an epitope on molecules of a soluble antigen.
B cells bind to toxins and digest them to smaller pieces, where the response
ends with descendants of B cell secreting antibodies (via plasma cells).
B CELL SELECTION
POSITIVE
NEGATIVE
B CELL ACTIVATION
T-CELL
T-CELL
INDEPENDENT
INDEPENDENT
ACTIVATION
ACTIVATION
MEMORY B CELL
ACTIVATION
ACTIVATION
1
B
2
A
2
B
3
B
4
A
4
B
Proses Pematangan
Timosit
pyogenic infections
Tidak ada circulating mature B cells, T cells
normal
Tidak ada plasma cells di Bone marrow, lymph
node, atau GI tract
Gen Btk termutasi
Very low serum levels all isotypes
immunoglobulin
TREATMENT
Intravenous Infusion (IVIg)
Muscle Injections (IMIg)
Subcutaneous (SCIg)
Antibiotics
Gene Therapy
Kesimpulan
Daftar Pustaka
Murphy, K. 2012. Janeways Immunobiology.