Professional Documents
Culture Documents
By :
Bella Anggraeni Sari
Rani Oktaviani Utina
Muh. Taufik Syarifuddin
BAGIAN ILMU KESEHATAN KULIT KELAMIN
FAKULTAS KEDOKTERAN UNIVERSITAS MUSLIM
INDONESIA 2014
Syphilis Curriculum
Epidemiology
Syphilis Definition
Sexually acquired infection
Etiologic agent: Treponema pallidum
Disease progresses in stages
May become chronic without treatment
Syphilis Curriculum
Epidemiology
Transmission
Sexual contact
Congenital infection
Blood products
Syphilis Curriculum
Epidemiology
syphilis incident various country in all the world in
Syphilis Curriculum
Syphilis Curriculum
Early Stage
T.Pallidum
skin or through membran
microlesi forming infiltrates in perivasculer
proliferate in T. Pallidum
hypertrophic in endothelium
obliteration
of the lumen
erosion
Syphilis Curriculum
Advance stage
Syphilis Curriculum
Pathogenesis
Treponema pallidum
Syphilis Curriculum
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Syphilis Curriculum
Clinical Manifestations
Primary Syphilis
Primary lesion or "chancre" develops at the site
of inoculation
Chancre:
painless, bilateral
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Syphilis Curriculum
Clinical Manifestations
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Syphilis Curriculum
Clinical Manifestations
Secondary
Syphilis
Secondary lesions occur 3 to 6 weeks after the
this stage
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Syphilis Curriculum
Clinical Manifestations
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Syphilis Curriculum
Clinical Manifestations
Secondary Syphilis:
Palmar/Plantar Rash
Syphilis Curriculum
Clinical Manifestations
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Syphilis Curriculum
Clinical Manifestations
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Syphilis Curriculum
Clinical Manifestations
Latent Syphilis
Host suppresses the infection enough so
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Syphilis Curriculum
Clinical Manifestations
Manifestations
Gummatous lesions
Cardiovascular syphilis
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Syphilis Curriculum
Clinical Manifestations
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Syphilis Curriculum
Clinical Manifestations
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Syphilis Curriculum
Neurosyphilis
Occurs when T. pallidum invades the CNS
May occur at any stage of syphilis
Can be asymptomatic
Early neurosyphilis occurs a few months to a few
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Syphilis Curriculum
Neurosyphilis - Spirochetes
in Neural Tissue
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Syphilis Curriculum
Clinical Manifestations
Congenital Syphilis
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Clinical Manifestations
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Syphilis Curriculum
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Differential diagnosis
S I
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S III
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Syphilis Curriculum
Diagnosis
Laboratory Diagnosis
Identification of Treponema pallidum in
lesions
Darkfield microscopy
Direct fluorescent antibody - T. pallidum (DFA-
TP)
Serologic tests
Nontreponemal tests
Treponemal tests
Histopatoloy
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Syphilis Curriculum
Primary syphilis
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Syphilis Curriculum
Prevention
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