Professional Documents
Culture Documents
Overview
1. Introduction: What is a disability?
Stroke
Head Injury & intracranial hypertension
Respiratory failure
1. What is a Disability?
Neuromuscular impairment
Sensory deprivation (vision, hearing or
speech)
Cognitive dysfunction (learning, higher
processing)
http://www.fi.au.dk/uk/jl/bc14/fig1403.jpg
Sensory: Vision
http://general.rau.ac.za/psych/Resources/Honours/Neuropsych/Images.htm
Sensory: Hearing
http://www.brainconnection.com/med/medart/l/anat/990705.jpg
Sensory: Speech
http://home.uchicago.edu/~skipp
er/pages/skipper.et.al.2005b.html
Sensory: Speech
http://www.cerebromente.org.br/n02/historia/areabroca.gif
Cognition
http://ifcsun1.ifisiol.unam.mx/Brain/speech.htm
The cortical association areas are thought to be the anatomical basis for
thought and perception, since stimulation of these areas produce little or no
obvert behavioral changes, but receive sensory input from high-order sensory
systems and project to motor cortex.
http://health.allrefer.com/health/stroke-secondary-to-cardiogenic-embolism-central-nervous-system.html
Neuron
http://www.mb.jhu.edu/tins/media/2004%20Neuron%20Schema1.jpg
http://www-ermm.cbcu.cam.ac.uk/02004477h.htm
http://caspar.bgsu.edu/~courses/Images/Neur/Synapse.jpg
Mitochondria
Mitochondria are structures that turn oxygen and glucose into energy. This
process is especially vital to brain cells. Although the brain accounts for only 2%
of the body's weight, it consumes more than 20% of the body's oxygen. All of
this energy is required because neurons transmit signals among themselves to
an even greater extent than do cells in the rest of the body.
http://www.cytochemistry.net/Cell-biology/mitoch1.htm
Aerobic metabolism
O2
fuel (glucose)
ADP CELLULAR
ATP
RESPIRATION
CO2 H2O
CO2 + H2O
biosynthetic work
mechanical work
transport work
H2CO3 H+ + HCO3
pH
PET can yield metabolic information with high-resolution images, and thus it
has the ability to detect small malignant lesions with increased metabolism for
enhanced cell proliferation.
Sensory: Vision
http://general.rau.ac.za/psych/Resources/Honours/Neuropsych/Images.htm
Eyes open
Congenital blindness
Eyes closed
Blind, recently
http://www.topo.ucl.ac.be/neuro_blindness.html
Children, epilepsy
http://www.md.ucl.ac.be/gren/Projets/Adv/childhoodEpilepsy.html
infants
Normal adult
Changes in brain oxygenation correlate with execution of a mental task (i.e. numerical calculation)
http://ccforum.com/content/9/6/R670
Figure 1
Figure 2
Plumbing
Berne &Levy:
O2
Berne&Levy: Figs. 32-6, p. 522
Hb
CO2
J.B.Wests Respiratory
Physiologythe essentials
O2
HbO2
PaO2
O2 Transport
2.
Cerebral Vasculature
MR Angiography
http://www.mgh-interventional-neurorad.org/diagnostic/mra.html
http://www.psyweb.com/Brain/Bimages/blood2.gif
O2 Carrying Capacity
The maximum amount of O2 that can be made to combine
chemically with Hb in a unit volume of blood. Where...
1g Hb combines with 1.34 ml O2
normal Hb content = 15 g Hb/100 ml of blood
O2 carrying capacity = (15 g Hb/100 ml) (1.34 ml/1 g Hb)
= 20.1 ml O2/100 ml of blood
% saturation of Hb =
HbO2
O2 carrying
capacity
100
http://www.cvm.okstate.edu/Courses/vmed5412/FIGURES/lecture03/fig3_12.gif
Stroke
http://www.mcg.edu/medart/images/2002-AR-Stroke.jpg
What is a stroke?
A stroke is the sudden death of brain cells
due to interruption of blood supply. When
blood flow to the brain is impaired, oxygen
and important nutrients cannot be
delivered. The result is abnormal brain
function.
A stroke is also referred to as a
cerebrovascular accident or CVA.
http://www.medicinenet.com/stroke/article.htm
http://www.ling.upenn.edu/courses/Summer_2004/ling001/images/brain_localization.gif
Causes of stroke, 1
Blockage of artery
Hardening of the arteries leading to the
brain
Causes of stroke, 2
Blockage of artery
Clogging of arteries within the brain (e.g.
lacunar stroke)
http://www.strokecenter.org/education/ais_vessels/ais050.html
Causes of stroke, 3
Blockage of artery
Embolism to the brain from the heart or an
artery
http://health.allrefer.com/health/stroke-secondary-to-cardiogenicembolism-stroke-1.html
Causes of stroke, 4
Rupture of an artery
(i.e. hemorrhage)
Cerebral hemorrhage (bleeding
within the brain substance)
Necrosis
http://medic.uth.tmc.edu/edprog/PATH/NeuroIIa.HTM
Head trauma
Cranial Volumes
10%
Blood
10%
CSF
10%
Extracellular
70% Intracellular
Monitoring ICP
Intraventricular Pressure Catheter
Intracranial Pressure
brain swelling
blood
(tumor)
Causes of stroke
Rupture of an artery
(i.e. hemorrhage)
Cerebral hemorrhage (bleeding
within the brain substance)
ICP
MAP
ICP
( drug overdose )
(brain
Respiratory Failure
5. Re-oxygenation
???
Reperfusion Injury
http://www.theresurrector.com/img/freeradicals.jpg
Re-oxygenation: superoxide
Oxidative Stress
SIGMA-ALDRICH
Re-oxygenation injury
http://cti.itc.virginia.edu/~psyc220/kalat/JK237.fig8.8.principle_area.jpg
http://camilolab.slu.edu/444/graphics/Leeson6-12.jpg
http://www.alscenter.org/images/human_motor_system_400pix.gif
http://stuserv.fullcoll.edu/images/Wheel%20chair%20student2.jpg
http://www.ia.wvu.edu/~magazine/issues/spring2003/htmlfiles/wheelchair.html
Homunculus
http://www.phrenology.com/homunculus.html
http://lcbr.ss.uci.edu/Courses/cog_neuro/lecture_slides/motor_system/Slide4.jpg
Neuron
http://www.mb.jhu.edu/tins/media/2004%20Neuron%20Schema1.jpg
http://www.awa.com/norton/figures/fig0209.gif
Action Potential
http://www.awa.com/norton/figures/fig0209.gif
Action Potential
http://www.awa.com/norton/figures/fig0209.gif
http://gargoyle.arcadia.edu/psychology/blustein/neuro/Lecture_Notes/
Week_1/Week_2/Action_Potential.jpg
http://www.cmj.hr/1999/40/3/400311.htm
Evoked Population
Spike
Overview
1. Introduction: What is a disability?
Stroke
Head Injury & intracranial hypertension
Respiratory failure