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Disease
Meraj Ondhia
Definition
Epidemiology
-Prevalence of H. Pylori infection:
Developing countries: 80-90%
Developed countries: 20-50%
-Infection is usually acquired during childhood by
various routes: faecal-oral, oral-oral, kissing or
ingestion of contaminated vomit
-Prevalence of peptic ulcer disease:
Duodenal ulcers: 10-15% of adult population
Gastric ulcers: 3-4 times less common than duodenal
ulcers
Both are common in the elderly
Aetiology
- H. Pylori
- Non-Steroidal Anti-Inflammatory
Drugs
- Zollinger-Ellison syndrome
- Stress
- Crohns Disease
Pathology
Antral Gastritis
-Antral Gastritis is normal result of H. Pylori infection ->
inflammatory response to H. Pylori induces G cells in pyloric glands
to secrete gastrin -> gastrin stimulates parietal cells to produce
gastric acid
-Increased acid production is usually asymptomatic
Duodenal Ulcers
Pathology
Curling ulcer
-Acute duodenal ulcer, complication of severe burns
-Reduced plasma volume leads to ischaemia and necrosis of
duodenal mucosa