Professional Documents
Culture Documents
Introduction to
Biochemistry
What is Biochemistry?
Biochemistryis the study of the chemical
substances and vital processes occurring in living
organisms.
Biochemistry dealswiththerole,function,structure
and interactions of biological macromolecules such
asproteins,nucleicacids,carbohydratesandlipids
.
BiochemistryisaResearchDisciplineApplicableto
RealWorld
Medicine:Biochemistryisusefulinunderstandingthe
diseasesanddevelopmentofdrugs
Agriculture:Inagriculture,biochemistryusedtoenhanced
thecropproductivityandqualityofyield,e.g.genetically
modifiedfoods(GMF)
Nutrition:Thevalueofdifferentfoodsources
(plants/animals)canbeexaminedandtheirsuitabilityfor
nutritionalbenefitsisassessed
Biochemistrycanbedividedintothreeareasofstudy
Conformational-structureandthree-dimensionalarrangements
ofbiomolecules.
Metabolismenergyproductionandutilization
Informational-languageforcommunicationinsideandbetween
cells
Biochemistryseekstodescribethestructure,organization,
andfunctionoflivingorganismsinmolecularterms
In order to understand the life on the molecular level,
you must first have a:
Knowledgeofthechemicalstructuresofthebiological
molecules
Understandingofthebiologicalfunctionofthemolecules
Understandingofbioenergeticsthestudyofenergyflow
incells
TheChemicalCompositionofBiomolecules
H, O, C and N make up 99+% of atoms in the human
body
ELEMENT
PERCENTAGE
Oxygen
63
Hydrogen
25.2
Carbon
9.5
Nitrogen
1.4
Hydrogen,Carbon,OxygenandNitrogencompriseover99%of
themassinmostcells
Theseelementsarethebackboneofbiomoleculesbecausethey
arecapableofformingstrongcovalentbonds
Chemical reactions that occur inside the cell are the same that
occur outside the cell
BiomoleculesareCarbonCompounds
orOrganicCompounds
Carbonatomscanfromsingle,doubleandtriplebonds
Moreimportantly,asinglecarbonatomcanformsinglebondswithupto
fourothercarbonatoms
Covalentlylinkedcarbonatomscanformlinearchains,branchedchains
andcyclicstructures
Covalentbondsarethegluethatholdscompoundstogether
Functional Groups
Groupsofotheratomsthatareattachedtothecarbonbackbone
Determinethechemicalproperties/diversityofthebiomolecules
Prokaryotes - Bacteria
Simplest Living System
Prokaryotes are unicellular
Prokaryotes generally have one cellular
membrane.
The interior is known as the cytoplasm
Eukaryotes
Eucaryotes are multicellular
Organelles
Function
Location of main genome; site of most
DNA and RNA synthesis
Mithochondrian
Chloroplast
Endoplasmic reticulum
Golgi apparatus
Lysozymes
Peroxisomes
Cell membrane
Cell wall
Central vacuole