Journal Reading

Roles of Adapalene in the

Treatment of Pityriasis Versicolor
Professional Mentor: dr. Bowo Wahyudi, Sp.KK
Click toBy:Nur
edit Darda Hajatulail
2011730078
Master title style

Click
to edit Master
subtitle
styleKELAMIN
STASE
KULIT
DAN

RSUD KOTA BANJAR

2015

Introduction
PITYRIASIS
VERSICOLOR
Fungal Infection of the skin
caused by Malassezia yeast
Diagnosis
Therapies
Characters
-Discrete or
Adapalene
concrescent
gel:
-slightly
Including:
A tretinoin
- Zinc
scaling
derivative
macules
prrithione
-clinical
and a
- Selenium
symptoms
selection
Hypopigmente
Sulfide
-direct
retinoic acid
- Antifungal
d or
microscopy
analogue
hyperpigment
agents
- Retinoic
ed area
-mainly on the
acid cream
upper trunk
However,
there are no reports on adapelene for the tratments of
and
neck
pityriasis versicolor

Subjects and Methods

Clinica
l Trial

A prospective
Double blind
Randomized controlled
study

Main aim
To compare efficacy of
adopalene with 2 % of
ketoconazole cream in
the treatment of
pytiriasis versicolor

Subjects and Methods

All
patients

Han people with pytiriasis

versicolor
clinical symptoms+KOH
examination

Exclusion Criteria:

Patients:
-who had received systemic/topical antimycotic at least 1
month prior to the study
-with serious diseases or other fungal infections
-with pregnant or nursing mothers
-with history of allergic to ketoconazole or adapalene
-who interupted the treatment

Subjects and Methods

Eligble
Patients
Group
One
Adapalene
gel twice
daily for two
weeks

Group
Two
2%
ketoconazole
cream twice
daily for two
weeks

During the
study
period, the
use of
another
drugs was

Subjects and Methods

(Statistics and Analysis)

To compare sex,
age, duration, and
lession affected area
between two group

Students and MannWhitney u test

To compare the
improvement rate
for each treatment
group

The x test
p values<0,05 were
considered as
significant results

Results

Results

Results

Discussion
Treatment with
oral ketoconazole
was effective for
Pytiriasis
Versicolor
Many patients
worry about the
side effects
Prefer topical
therapy

Thus, we try not

only clear
infections fungi,
but also avoid
drug resistence
Possibly promotes
the drugs
resistence of
fungi
Frequent use

Discussion

Tretinoin cream was effective for

treatment of pytiriasis
versicoloradapalene gel is tretinoin
derivitative

Discussion
How can we account for the efficacy
of adapalene in the tratment of
pytiriasis versicolor?
Adapalene

Thus

1. Strip
abnormal
keratynocytes
2. Normalize the dysfunction
3. Dicrease
the
sebum
secretion

Adapalene gel promotes an

environment in hospitable to
Malassezia
yeasts
eliminated together with
the abnormal cell layer

Conclussion
In this study we found that adapalene gel
was not inferior to 2% ketoconazole
cream in the treatment of pityriasis
versicolor.
Adapalene is a favorable option in the
treatment of pityriasis versicolor

References

THANK YOU