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Immune System
A complex of
lymphoid organs
highly specialized
cells
circulatory system
separate from
blood vessels
Immune System
Lymphatic vessels
form a circulatory
system that operates
in close partnership
with blood circulation
Carries lymph, a fluid
that contains WBCs
(chiefly lymphocytes)
Lymph nodes provide
meeting grounds
Fungi
Bacteria
Candida albicans
Tubercule bacillus
Staphylococci
Myeloid progenitor
Monocyte
Lymphocyte
progenitor
Macrophage
Basophil
Dendritic cell
Neutrophil
B cell
NK cell
Thymus
Mast cell
CD8
T cell
CD4
T cell
Plasma
cell
Eosinophil
Association
Association between
between
immunodeficiency
immunodeficiency and
and
cancer
cancer
cause of
immunodeficiency
primary
(inherited)
immunodeficien
secondary
cy
(acquired)
immunodeficiency
malari
a
autoimmuni
ty
malignanc
y
lymphoma
s
lymphoma, cervical
cancer, liver cancer,
skin cancer, Kaposis
sarcoma.
Burkitts lymphoma
lymphom
a
Tumors
Tumors stimulate
stimulate an
an immune
immune
response
response
Animals
Animals can
can be
be immunized
immunized against
against
tumors
tumors
Immunity
Immunity is
is transferable
transferable from
from
immune
immune to
to nave
nave animals
animals
Tumor
Tumor specific
specific antibodies
antibodies and
and cell
cell
have
have been
been detected
detected in
in humans
humans
with
with some
some malignancies
malignancies
Etiology Of Tumor
1) Inherited :
Expression of inherited oncogene
e.g. viral gene incorporated into host gene
2) Viral:
- Human papilloma, herpes type 2, HBV, EBV (DNA)
- Human T-cell leuckemia virus (RNA)
3) Chemical:
- Poly cyclic hydrocarbons cause sarcomas
- Aromatic amines cause mammary carcinoma
- Alkyl nitroso amines cause hepatoma
4) Radiological: Ultraviolet & ionizing irradiation
5) Spontaneous: failure in the cellular growth control
Immunity
Immunity against
against
tumor
tumor
All
All components,
components, specific
specific and
and
nonspecific,
nonspecific, humoral
humoral and
and
cellular
cellular affect
affect tumor
tumor progression
progression
and
and growth
growth
Antigens expressed on
tumor cells
Major Histocompatabili
Complex antigens
TST
A
TATA
TSTA
Tumor-specific
transplantation Ag
Tumor-associated
transplantation Ag
: unique to a tumor
Play an important role in tumor rejection.
TATA : shared by normal and tumor cells
Tumor-associated developmental Ag (TADA)
Tumor-associated viral Ag (TAVA)
Tumor
Tumor associated
associated transplantation
transplantation
antigens
antigens:: shared
shared Ag
Ag on
on virally
virally induced
induced tumors
tumors
Discovery
Discovery of
of tumor
tumor specific
specific
transplantation
transplantation antigens,
antigens, TSTA
TSTA
Escape
Escape from
from
immunosurveillance
immunosurveillance
Lack of
Neo-antigens
Escape
Escape from
from
immunosurveillance
immunosurveillance
Lack of
Neo-antigens
Escape
Escape from
from
immunosurveillance
immunosurveillance
Lack of
class I MHC
Escape
Escape from
from
immunosurveillance
immunosurveillance
Tumors secrete
Immunosuppressive
molecules
Escape
Escape from
from
immunosurveillance
immunosurveillance
Class I MHC
tumo
r
B7
tumor
Ag
CD28
CTL
Utility of Immunology
in
Cancer Treatment
Use
Use of
of tumor
tumor associated
associated antigens
antigens
monoclonal
monoclonal antibodies
antibodies
Monoclonal
Monoclonal antibodies:
antibodies:
use
use as
as aa diagnostic
diagnostic tool
tool
Immunotherapy
Immunotherapy of
of tumors
tumors
active immunotherapy
specific
nonspecifi
c
nonspecific
specifi
c
passive immunotherapy
LAK cells,
cytokines
antibodies alone or conjugated
with other agent, activated T
cells
Non-specific
Non-specific immunotherapy
immunotherapy
BCG, P. acnes,
muramyl
dipeptide
pyran, poly I:C
bacterial
products
activate macrophages
and NK cells (via
cytokines)
synthetic
molecules
interferon production
cytokines
IFN-, IFN-, IFN-, IL2, TNF-
activate macrophages
and NK cells
Cytokine
Cytokine immunotherapy
immunotherapy
IFN
IFN
remission of hairy
cell leukemia,
weak effect on
carcinomas
remission of
ovarian carcinoma
IL-2
remission in renal
cell carcinoma and
melanoma
TNF
reduction in
malignant ascites
increased expression
of class-I MHC,
possible anti tumor
effect
increased expression
of class-I MHC, Tc
and NK cell
activation
T cell proliferation
and activation, NK
cell activation
macrophage and
lymphocyte
activation
Thank You