EARLY-PREGNANCY PERCENT BODY

FAT IN RELATION TO PREECLAMPSIA

RISK IN OBESE WOMEN
By:
R.A Delila Tsaniyah
Maghfiroh Rahayu Nindatama
M. Rizky
Galih Cahya Wijayanti
Ahmad Syaukat
Muhammad Fakhri Altyan
Dwi Lestari
Elisha Jethro Solaiman
Advisor:
Dr. dr. Ferry Yusrizal, Sp.OG. K. M.Kes
DEPARTMENT OF OBSTETRIC AND GYNECOLOGY OF FACULTY
OF MEDICINE UNSRI
MOHAMMAD HOESIN HOSPITAL PALEMBANG

Outline

Background
Preeclampsia is a serious pregnancy complication occurs in 58% of pregnancies in US
Accounts for approximately 15% of all preterm births
Maternal prepregnancy obesity is one of the strongest
modifiable risk factors for preeclampsia
The amount of body fat may help to determine which obese
women will experience preeclampsia
BMI is not an optimal indicator for percent body fat and less
reliable in pregnancy
BIA was used to estimate body fat in pregnancy

Objective
to identify differences of early-pregnancy body fat percentage
and body mass index (BMI) between obese women that
experienced preeclampsia and those who did not.

Materials and Methods

Results

Study participants were aged 23,7 4,1 years; 63% of them were black, and
20% of them were smokers
The average BMI was 33,1 7,8 kg/m2; most were overweight (20%) or
obese (64,1%)
Gestational DM were more common in clinical preeclampsia (6,9%) and
research preeclampsia (14,3%)
Mean gestational age at delivery was 39,5 1,3 weeks (39,0 1,3 weeks for
clinical, 38,1 1,7 weeks for research)
There was no significant differences between obesity metrics (BMI, etc) in
preeclampsia and normal pregnancies

Only the highest category of obese women (BMI>40 kg/m2) was the body fat
percentage significantly higher in preeclampsia compared with who did not
have preeclampsia

Comparing BMI and percent body fat as predictor of preeclampsia in obese women
(BMI> 30 kg/m2)
Higher BMI was associated significantly with higher risk for the research definition of
preeclampsia but not for clinical definition, but not statistically significant any more
after adjustment

Percent body fat was associated significantly with higher risk for both research and
clinical definition of preeclampsia
1% increase in body fat, the risk of clinical preeclampsia increased 12% and the risk
of preeclampsia by the research definition increased 24%

The exact mechanism underlying relationship between percent body fat and
preeclampsia remain unidentified

Conclusions
Early pregnancy body fat appears to be important in the pathophysiology
condition of preeclampsia in obese women

Critical Appraisal
PICO

Validity

Importance

Applicability

Conclusion
This journal is valid, important, and can be applied for the associated future
research.

Thank You