A New Diagnostic for

Invasive Fungal Diseases

Rina Arad-Yellin
Idan Bodaker
Bernard (Buddy) Green
Pears Program for Global Innovation
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May 16, 2015

Invasive Fungal Diseases

A growing world-wide problem especially prevalent
and deadly in developing countries such as India
Life-threatening diseases, high mortality rates
Endangers a growing number of immunocompromised patients
Lack of rapid and reliable diagnosis
Treatments are often based on clinical educated
guess causing needless toxicity and expenses
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Semorex Innovative Technology

A rapid diagnostic approach that uses ergosterol, a
unique biomarker for all fungi
The biomarker is extracted from body fluids,
derivatized and analyzed by high performance liquid
chromatography.
The principle was demonstrated with 100 clinical
samples
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Advantages

Quick
Reliable
Sensitive

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Specific
Yes/No Answer
A life-, time- and money-saving test

Semorex Innovative Technology

Extraction of the biomarker, derivatization and
analysis using antibodies is the heart of the new
approach
A small device, based on antibodies, that indicates
the biomarker by a color change is the target of the
program

Schematic of Semorex Lateral Flow Device

Taken from Lab-on-Paper Technology Enhances Medical Diagnostics - Bridget Cunningham,

March 2015

Summary
Novel proprietary diagnostic method for IFDs
Improved method ready for validation and clinical trial to
support regulatory approval
During the current year seek to raise $5 million to
complete development and submit applications for
approval to regulatory agencies
Commercialization via collaboration with large diagnostic
companies with established market presence
Target India as 1st market and then promote in other
developing countries
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Thank You!
Etgar-Grand Challenges Israel (Mashav; Foreign
Ministry; Office of Chief Scientist)
Pears Program for Global Innovation

Michael Giladi, M.D.

Associate Professor of Medicine Infectious Disease Unit and Bernard
Pridan Laboratory for Molecular Biology of infectious Diseases, Tel Aviv
Sourasky Medical Center, Israel

Ronen Ben-Ami, M.D.

Director, Molecular Mycology Laboratory Infectious Disease Unit and
Molecular Biology of Infectious Diseases ,Tel Aviv Sourasky Medical
Center, Israel
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