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OF LEIOMYOMA
CLASSIFICATION BY
LOCATION
Submucosal - lie just beneath the endometrium
Intramural - lie within the uterine wall
Subserosal - Lie in the serosal surface of the
uterus or may bulge out from the myometrium
and can become peduculate
PREDISPOSING FACTORS:
1. AGE is a risk factor in the disease process of the
uterine leiomyomas. this is due to the differences of
estrogen and progesterone levels in females as they
get older and undergo the processess of menopause.
2. RACE although an actual connection between the
disease process and race have yet to been validated
and affirmed, many studies have shown that particular
races such as Amercian and African American are
more susceptible to tumor growth in the endometrial
lining among premenopausal women.
PREDISPOSING FACTORS:
3. HEREDITY Women whose mothers have had
myoma themselves are more susceptible to getting
the disease that those who have no family history of
the disease.
4 EARLY MENARCHE AND NULLIPARITY Studies have
suggested that an early start of menarche (less than
the average of 13) and nulliparity contribute to the
development of a uterine leiomyoma, however, how
this connection or relationship between the risk
factors and the disease are unknown. It is beleived
that these facotors are precipitated because of the
estrogen and progesterone levels in the body.
PRECIPITATING FACTORS:
1. HIGH FAT DIET AND OBESITY is also considered
source of estrogen where as diets rich in fiber and
low in fat decreases estrogen rearbsorption. Fat has
an enzyme that converts adrenal steroids to
estrogen.
PRECIPITATING
FACTORS:
3. ORAL CONTRACEPTIVES promotes estrogen
domincance and eventually influence the growth of
the cells in the uterus