Professional Documents
Culture Documents
Response
Learning Outcomes:
List the changes in external and internal
environment faced by an organism
State why organisms have to be
sensitive to the changes in environment
Clarify through examples the meaning
of stimulus and response
State the components and pathways of
information due to external and internal
stimuli
State the meaning of coordination.
Changes occur in
internal environment
Sugar
level,
body
temperature & osmotic
pressure of the blood.
Type of receptor
Location of receptor
Light
Photoreceptor
Sound
Mechanoreceptor
Ears
Chemical
Chemoreceptor
Touch
Mechanoreceptor
Skin
Pressure
Mechanoreceptor
Pain
Pain receptor
Skin
Gravity
Mechanoreceptor
Ears
Air
Temperature
Thermoreceptor
Skin
Type of receptor
Location of receptor
Body temperature
Thermoreceptor
Hypothalamus
(in brain)
Osmoreceptor
Hypothalamus
(in brain)
Blood pH
Chemoreceptor
Medulla oblongata,
aortic and carotid artery
Chemoreceptor
Blood pressure
Baroreceptor
Pancreas
Aortic and carotid
artery
Afferent
neurone
carries nerve
impulses to
Triggers
nerve
impulses
Afferen
t
pathwa
y
detected
by
External Stimulus
(Sound of car horn)
Efferen
t
pathwa
y
Efferent
neurone
carries
nerve
impulses to
Effector
(Muscles in leg)
reacts to
cause
Response
(Move away
from the
incoming car)
Sends
nerve
Integrating centre impulses
(Brain)
impulses
Afferen
t
Receptors in the skin
pathwa
(heat receptor)
y
detected
by
Internal Stimulus
(High body temperature)
Efferen
t
pathwa
y
Efferent
neurone
carries
nerve
impulses to
Effectors
(Skin and
endocrine
glands)
reacts to
cause
Response
(Increase heat
loss)
Sensor
y
Transmits information
Interprets information
Formulates appropriate responses
to effectors
Controls and coordinates functions
throughout
body
and
helps
maintain homeostasis
Integrat
ion
Moto
r
The nervous
nerve cells called
Consists
of
e.g.
Cranial
nerve
Spinal
nerves
of millions of
Carries
impulses to
CNS
Carries
impulses
away from
CNS
Components of CNS:
1) The Structure Of Human Brain
The brain is composed of
three main parts:
~ cerebrum
~ cerebellum
~ brain stem
(pons & medulla
oblongata)
There are other
components such as:
~ thalamus
~ hypothalamus
* pituitary glands
(not component of nervous
system)
Refer textbook page 79,
Figure 3.5
16
Thalamus
Cerebellum
Pituitary gland
Medulla oblongata
a) Cerebrum
The cerebrum, the largest part and most
complex of the human brain, is divided into
left and right hemispheres.
The hemispheres are covered by a thin layer of
grey matter known as the cerebral cortex.
Each hemisphere has folds and grooves to
increase the surface area of the
cerebrum. (to store more neurons)
The left hemisphere controls all activities on the
right side of the body.
The right side controls all activities on the left
side of body.
The right hemisphere of the cerebrum is
associated with creativity and artistic
ability.
18
The left hemisphere is associated with
Cerebrum
Motor area
Ta
m ct
us ile
cl &
e
se
ns
leg
al
t
en
arm
m
er ies
h
ig it
Eyes
H tiv
Head
ac
speechFace hearing
front
back
vision
Tasting
Movement
Hearing
Body balance
22
Dorsal root
(sensory
neurons)
Contain axon
of afferent
neurone
Dorsal root
ganglion
Contain cell
bodies of
afferent
neurone
31 spinal nerve
emerged from spinal
cord
Consists
myelinated
axons of
neurones
Cell body
Contains a nucleus,
cytoplasm and other
Serves as a control
organelles
centre
Neurilemma
Forms the cell
membrane of a
neurone
Myelin sheath
Insulates the axon
and speeds up the
transmission of
impulses
Dendrites
Carry the impulses
towards the cell body
Nucleu
s
Dendron (Transmits
impulse
Axon
towards
the cell impulse
body)
(Transmits
away
from the cell body)
Nodes of Ranvier
Where the neurilemma
constricts,
helps
to
speed up transmission of
nerve impulse
Muscle fibres
Dorsal root
(sensory
neurons)
Contain axon
of afferent
neurone
Dorsal root
ganglion
Contain cell
bodies of
afferent
neurone
31 spinal nerve
emerged from spinal
cord
Consists
myelinated
axons of
neurones
33
Contains a nucleus,
cytoplasm and other
Serves
as a control
organelles
centre
Neurilemma
Myelin sheath
Dendrites
Carry the impulses
towards the cell body
Nucle
us
Dendron
transmits impulse towards
the cell body)
Axon
Transmits impulse away
from the cell body)
Nodes of Ranvier
Where the neurilemma
constricts,
helps
to
speed up transmission of
nerve impulse
Muscle
fibres
Efferent
neurone
Interneurone
Interneurone
Synapse
A synapse is the site where one neurone
connects to another neurone
Synapse occur between the synaptic knobs of
the terminals of the axon of the presynaptic
neurone and a dendrite of a postsynaptic
neurone
The
tiny gap between the two neurones is
known as the synaptic cleft
When an impulse reaches a synapse, the small
synaptic vesicles clustered at the tip of the
axon release chemical substances called
neurotransmitters
To cross the synaptic cleft requires the actions
of neurotransmitters.
Examples
of
neurotransmitters
are
acetylcholine, dopamine, noradrenalin and
serotonin.
Synaptic
knob of
terminal
axon of
presynapti
c neurones
Dendrite
of
postsynapt
ic
/ synapse
Synapse
The neurotransmitter diffuses across the
synaptic cleft to generate fresh impulses
in the adjoining neurone
After performing their function, the
neurotransmitter is quickly broken down
by enzymes and rendered inactive
Because of this, nerve impulses are made
to travel in one direction only.
Neurotransmitters tend to be small
molecules, some are even hormones.
The time for neurotransmitter action is
between 0.5 and 1 millisecond.
Synaptic
knob of
terminal
axon of
presynapti
c neurones
Dendrite
of
postsynapt
ic
/ synapse
51
Cont
Arrival of the action potential causes some of the
vesicles to move to the end of the axon and
discharge their contents into the synaptic cleft.
Released neurotransmitters diffuse across the cleft,
and bind to receptors on the other cell's membrane,
causing ion channels on that cell to open.
Neurotransmitters tend to be small molecules, some
are even hormones. The time for neurotransmitter
action is between 0.5 and 1 millisecond.
The neurotransmitters cross the cleft, binding to
receptor molecules on the next cell, prompting
transmission of the message along that cell's
membrane.
Acetylcholine and noradrenaline are the examples of
a neurotransmitter.
52
Control by cerebrum
Voluntary Action
(under the control of the will of individu
Voluntary Action
Initiated by the motor centres of the
cerebral cortex
The pathway of transmission of information
in voluntary action
Stimulus
Response
Afferent nerve
Receptors
Effector
Efferent nerve
Sensory
areas of
the
cerebral
cortex
Motor area
of the
cerebral
cortex
Involuntary Action
Reflex Action
A quick automatic response to an external
stimulus
Happen very rapidly
Without conscious control
Involves contraction of skeletal muscles and
spinal cord only.
The nerve pathway involved in a reflex action is
called a reflex arc
The knee jerk reflex is a two-neurone reflex arc
(no interneurone)
The withdrawal of hand from hot object reflex is
a three-neurone reflex arc
ITeach Biology Form 5
Parkinson's disease is a
degenerative disorder of
the CNS that often
impairs the sufferer's
motor skills and speech.
It is due to the reduced
level of
neurotransmitters called
dopamine in the brain.
It is characterized by
tremor, a slowing of
64
B. Alzheimers Disease
Alzheimers disease is neurological disease
characterized by increasing loss of memory and
intellectual ability.
The diease is associated with the shrinkage of
brain tissues and lack of neurotransmitter such
as acetylcholine.
Signs of Alzheimer's: memory loss,
disorientation to time and place, problems with
abstract thinking, misplacing things, changes in
mood or behavior.
Risk factors :
i. Age
Most individuals with the disease are 65 or
older.
ii. Family history
66
Another risk factor is family history.
c. Epilepsy
Epilepsy is a brain disorder that causes
people to have recurring seizures. The
seizures happen when clusters of nerve
cells, or neurons, in the brain send out the
wrong signals.
Epilepsy has many possible causes,
including illness, brain injury and abnormal
brain development.
Doctors use brain scans and other tests to
diagnose epilepsy. It is important to start
treatment right away. There is no cure for
epilepsy, but medicines can control seizures
for most people. When medicines are not
working well, surgery or implanted
67 devices
d. Multiple Sclerosis
Multiple sclerosis is a
CNS disorder marked by
decreased nerve function
with initial inflammation
of the protective myelin
nerve covering and
eventual scarring.
The symptoms of MS can
be different from person
to person. Visual,
sensory, and motor signs
and symptoms are all
part of MS.
68
e.Poliomyelitis
Poliomyelitis (polio) is a
highly infectious disease
caused by a virus.
It invades the nervous
system, and can cause
total paralysis in a matter
of hours.
The virus enters the body
through the mouth and
multiplies in the intestine.
Initial symptoms are fever,
fatigue, headache,
vomiting, stiffness in the
neck and pain in the
limbs.
Polio mainly affects
children under five years
of age.
There is no cure for polio,
69
Chapter 3 Coordination
And Response
3.3 Role Of Hormones
In Humans
Function Of Hormones
A) in reproduction
~ Follicle Stimulating Hormone (FSH)
~ Luteinising Hormone (LH)
~ Oestrogen
~ Progesterone
~ Testosterone
B) in growth
~ Growth hormone (GH)
~ Thyroid stimulating hormone (TSH)
~ Thyroxine
C) in homeostasis
~ insulin
~ glucagon
~ antidiuretic hormone (ADH)
~ aldosterone
~ adrenaline
Groups Of Hormone
Can be classified into two groups:
a) Steroid hormone:
~ produced from a lipid called
cholesterol
b) Non-steroid hormone:
~ are made up of proteins, small
peptides and modified amino acids
* Control the
pituitary
gland
* Produces hormones
to regulate activities of
other endocrine gland
2
3
4
5
Hormones
Function
Anterior
pituitary gland
Follicle Stimulating
Hormone (FSH)
Luteinising
Hormone (LH)
Adrenocorticotrophic
Hormone (ACTH)
Stimulates
hormones.
adrenal
cortex
to
release
Growth hormone
Prolactin
Hormones
Function
Posterior
pituitary
gland
Oxytocin
Thyroid gland
Endocrin
e gland
Hormones
Function
Thyroxin
Increases body
temperature
Adrenal Gland
Endocrine
gland
Hormones
Adrenal
cortex
medulla
Function
Aldosterone
Increases reabsorption of
salt in kidneys
Adrenaline and
noradrenalin
Adrenal Gland
Kidney
Pancreas
Endocrine
gland
Pancreas
Function
Hormones
Insulin
(secreted by beta cells of
islet of Langerhans)
Glucagon
- Increases blood glucose level
(secreted by alpha cells of Converts glycogen to glucose
islet of Langerhans)
pancreas
A Look At History
Islet of Langerhans
~ Paul Langerhans, German anatomist
discovered clusters of cells in the
pancreas.
~ He called them Islet of Langerhans.
~ Each islet includes beta cells which
secrete
insulin and alpha cells which secrete
glucagon.
Ovaries
Endocrine
gland
Hormones
Function
Oestrogen
Stimulates
development
of
female
secondary sexual characteristics,
repair of the uterine lining,
stimulates the development of eggs and
female reproductive organ
Ovaries
Progesterone
Testis
Endocrine
gland
Testis
Hormones
Testosterone
Function
Stimulates
development
of
secondary sexual characteristics
Stimulates
sperm
production
development of testes
male
and
Bio Insight
Endocrine glands are amazingly small
The pituitary gland is only as large as a pea.
All the bodys endocrine tissues would fit into
the palm of ones hand.
The quantity of hormone produced is also
slight.
Eg:
~ the average woman produces only about 5 ml
of
estrogen in her entire lifetime.
Hormones are very powerful and are effective
at concentration as low as one part per million.
Secretion Of Hormones
Various (3) ways hormones are produced:
1) secretion of hormones regulated by
another hormone
2) secretion of hormones regulated by
levels
of certain substances
3) secretion of hormones regulated by
nervous system
1) Secretion Of Hormones
Regulated
By
Another
Hormone
Example:
~ The release of the hormone thyroxine is regulated by the
thyroid-stimulating hormone (TSH)
~ A high level of thyroxine:
1) inhibits the release of the thyroid-stimulating hormone
from pituitary gland
2) so, stops the release of additional thyroxine from thyroid
gland.
~ A low level of thyroxine:
1) stimulates the secretion of the thyroid-stimulating
hormone
2) then, stimulates the thyroid gland to secrete thyroxine.
The effect of
deficiency of the
hormone
Growth
hormone
(GH)
Thyroxin
Goitre enlargement of
thyroid gland
Cretinism (in children)
Hypothyroidism
(in
adult)
Insulin
Diabetes
mellitus
(diabetes)
Antidiureti Diabetes inspidus
c hormone - Large volume of urine is
(ADH)
excreted and body loses
a lot of water
The effect of
excess of the
hormone
Gigantism
children)
(in
Hyperthyroidism
(in adult)
Hypoglycaemia (Low
blood sugar level)
Oedema
accumulation
of
excess fluids in the
body
Cretinism
Hypothyroidism
Hyperthyroidism
Gigantism
Dwarfism
Diabetes inspidus
Oedema
Diabetes mellitus
Hormones
GH
GH and
Thyroxine
Insulin
Oestrogen
Oestrogen
and
Progesterone
Progesterone
Uses
Treat dwarfism
Treat cretinism
Treat diabetes mellitus
treat the problem of secondary
sexual development,
menstruation or menopause
and prevent osteoporosis
used in the conctraceptive pill
to alter the hormonal balance in
the menstrual cycle and
prevent ovulation
used to strengthen and thicken
the wall of the uterus to
Extra info
Cretinism
~ can be prevented by the addition of a small amount of
iodine in
table salt or food.
Diabetes mellitus
~ two types of diabetes mellitus
Type I ~ diabetes is due to LITTLE or NO secretion of
insulin.
~ usually occurs before the age of 15
~ requires insulin injections to keep the normal
blood glucose
level
Type II ~ diabetes is due to the cells not being able to
properly
respond to the hormone
~ develops after the age of 40
3.4 Homeostasis In
Humans
Homeostasis
The regulation / maintenance of physical and chemical
factors in the internal environment at constant level for
the body cells to function optimally.
Physical
factors
Chemical
factors
- Body temperature
- Blood pressure
- Partial pressure of oxygen and carbon dioxide
- Osmotic pressure
- Sugar levels
Importance of homeostasis:
To ensure physiological processes proceed at optimum
rates to promote harmonious growth and development
To ensure survival of organisms
Introduction of Concept of
Homeostasis in Humans
The term was coined in 1932 by
Walter Bradford Cannon from the Greek homoios
(same, like, resembling) and stasis (to stand, posture).
Homeostasis is the maintenance of the internal
conditions within tolerable limits, which is one of the
fundamental characteristics of living things.
* The excretory system plays an important role in
homeostasis. The primary organs are the kidneys.
103
104
Right kidney
Left kidney
Blood in
from heart
Right
renal vein
Left renal
artery
106
Dorsal aorta
Renal vein
Cortex
Medulla
Right
kidney
Carries
oxygenated
blood
together with nitrogenous waste
products from the heart to the
kidney
Ureter
Stores urine
Urethra
Renal vein
Each kidney
about
one
nephrons
Renal artery
contains
million
One nephron
pelvis
cortex
medulla
ureter
Human Kidney
The figure shows a
longitudinal section of a
kidney.
A longitudinal section
through a kidney shows
three distinct areas:
A. an outer region called
the cortex
B. a middle region called
the medulla
C. an inner region open
into the ureter,
called the pelvis.
proximal
convoluted tubule
Bowmans capsule
distal convoluted
tubule
Bowmans
capsule
Pelvis
loop of Henle
Proximal convoluted
tubule
Collecting duct
U-shaped
loop of Henle
Distal convoluted
tubule
Reabsorption
Secretion
tubule
Efferent arteriole
Bowmans capsule
glomerulus
Blood
Afferent arteriole
1. Ultrafiltration
Blood from the renal artery is supplied to each Bowman's
capsule by arterioles and capillaries which eventually
form a ball of tiny capillaries inside the capsule called a
glomerulus.
The afferent arteriole which leads to the glomerulus has a
larger diameter than the efferent arteriole which leaves the
glomerulus.
The blood in the glomerulus is under high hydrostatic
pressure.
As a result, the fluid in the glomerulus is forced / diffuse
out into the lumen of the Bowmans capsule.
Only small molecules can be filtered, large molecules
such as blood protein and blood cells cannot pass
through the tiny pores in the walls of the capillary and
Bowmans capsule.
1. Ultrafiltration
Blood (together with unfiltered substances)now leaves the
Bowman's capsule in another arteriole and then diffuse
through many tiny blood capillaries that twine themselves
round and round the tubules.
Now, the substances which have been filtered out in the
glomerulus called as glomerular filtrate.
The main component: water, urea, glucose, amino acids
and salts.
2. Reabsorption
As the filtrate passes through the proximal convoluted
tubule, all the glucose, amino acids, hormones, vitamins,
and some salts are reabsorbed by active transport into the
blood capillary. But, urea is not reabsorbed.
With these solutes now removed, the glomerular filtrate
becomes dilute, and about 65% of water is reabsorbed
into the blood capillaries by osmosis.
As the filtrate passes along the loop of Henle, about 20%
of the water and some salts (sodium and chloride ions)
are reabsorbed into the blood capillaries.
At the Loop of Henle, the ion content is also adjusted to
maintain the blood pH of between 7.3 - 7.4.
As the fluid passes on through the distal convoluted
tubule and collecting duct, some adjustments are made
and further reabsorption of water and salt may take place,
depending on the current needs of the body.
3. Secretion
Along the distal convoluted tubule, waste products such as
urea, uric acid and ammonia are secreted out from the blood
capillaries into the distal convoluted tubule by active
transport.
This process is called secretion.
Secretion takes place in the renal tubules (proximal, loop of
Henle, distal) and collecting ducts but is especially active at
the distal convoluted tubule.
Some drugs and other toxic substance are also secreted out
from the blood capillaries by simple diffusion.
The final filtrate which remains in collecting duct is called
urine.
The major constituents of urine are water, mineral salts,
nitrogenous products (urea), ammonia, creatinine and bile
pigment.
From the collecting ducts, the urine flows down the pelvis,
ureter, bladder and the urethra and is finally excreted.
Normally, urine is clear and ranges from pale to deep yellow in
colour. It is slightly acidic
Afferent arteriole
Bowmans capsule
Glomerular filtrate
Blood capillary
Glucose,
amino
acid,
mineral salts reabsorped
through active transport
Proximal convoluted
tubule
Loop of Henle
Active
secretion
ammonia, urea
Distal convoluted
tubule
More
mineral
reabsorped
Collecting duct
of
salts
Ureter
Urine containing 95% water with urea, ammonia, uric acid,
creatinine, sodium chloride and potassium ions.
Body (cells)
What Is Creatinine?
What Is Creatinine?
Creatinine is a chemical waste molecule that is
generated from musclemetabolism.
Creatinine is produced from creatine, a molecule of
major importance for energy production in muscles.
Approximately 2% of the body's creatine is converted
to creatinine every day.
Creatinine is transported through the bloodstream to
the kidneys.
The kidneys filter out most of the creatinine and
dispose of it in the urine.
Because the muscle mass in the body is relatively
constant from day to day, the creatinine production
normally remains essentially unchanged on a daily
basis.
A Story Of Camel
Camels live in the desert. They have several
adaptations that allow them to withstand long
periods of time without any water. How the
nephrons in the kidney of the camels adapt
themselves to the desert environment?
lessOther example:
B. Osmoregulation
Osmoregulation is the process of keeping a
constant amount of water and salts in the
blood to maintain the blood osmotic pressure.
Our bodies need to constantly replace the
water being lost in breathing, sweating, urine
and faeces, as our cells cannot function
without sufficient water.
If there is too much water in our bodies,
however, it will move by osmosis into the
cells, which may swell or even burst.
A balance is needed, and again it is the
hypothalamus which maintains this balance .
124
B. Osmoregulation
When the osmoreceptors in hypothalamus detects too
much water in the blood:
Eg: A person drinks unusually large amount of water.
(Osmotic pressure in the blood decreases)
(a) Pituitary glands
~ NOT stimulated to release ADH.
~ LESS water reabsorbed
(b) Adrenal gland
~ stimulated to release aldosterone
~Cells lining distal convulated tubule and collecting
duct become more
permeable to salts.
~ more salts reabsorbed into blood
(c) This increases the osmotic pressure to its normal
level.
Urine produced is dilute and large in amount.
So the blood water level returns to normal.
dialysis fluid
goes out
Pam
Bubble trap
From radial artery
blood returns
to patient
To vein
Dialysis fluid (containing glucose,
amino a. and inorganic ions and is
isotonic to blood plasma.)
Glucose,
amino acid and
urea
diffuse
out of blood
into
dialysis
fluid
semi-permeable
tube
Donor
kidney
Donor
ureter
Urinary
bladder
Negative Feedback
Mechanisms
1) Regulation Of Blood
Sugar Level
134
135
144
3.5 Practicing A
Healthy Life
(a) Stimulants
(b) Depressants
(c) Hallucinogens
147
(a) Stimulants
Stimulants increase the activity of the either
peripheral nervous system (PNS) , the central
nervous system (CNS) or both.
Stimulants are used :
~ to increase or maintain alertness
~ to counteract fatigue in situations where sleep is
not practical,
~ to counteract abnormal states that diminish
alertness consciousness,
~ to promote weight loss
~ to enhance the ability to concentrate in people
diagnosed with attentional disruptions.
Example of stimulants:
1. Caffeine, found in beverages such as coffee and
soft drinks, as well as nicotine, which is found in
tobacco smoke.
2. other well known stimulants include ephedrine,
amphetamines, cocaine, methylphenidate.
148
(b) Depressants
Drugs which depress the activities of the
nervous system.
Depressants are capable of alternating the
functioning of the cerebrum and give a false
sense of well-being.
E.g. opiates (opium, morphine, heroin and
codeine), barbiturates, tranquilizers, anesthetics
(ether and chloroform) and alcohol (ethanol).
(c) Hallucinogens
Affect perceptions and cause hallucinations.
The user may see and hear things which are
actually non-existent and tend to be highly
emotional.
Alcohol Abuse
Alcohol is kind of depressant.
It weakens the functions of the brain and affects
vision, hearing and speech.
A higher dosage can impair coordination needed to
maintain balance.
The factors may lead to drug and alcohol abuse:
a. A chaotic home environment and lack of affection
from parents
b. Emotional distress
c. Peer influence
d. Curiosity
e. Having parents who take drugs
150
Apical meristem
Zone of elongation
Zone of differentiation
Phloem
Permanent tissues
Axillary
bud
Root hair
Xylem
Phloem
Zone of elongation
Cell elongates
Apical meristem
Root cap
Cells
elongate
Cells undergoing
mitosis
Zone of
elongation
Zone of
division
Inference
The tip of the coleoptile
influences growth in the
zone of elongation
Examples Of Tropism
Phototropis
m
Direction of
light from
one side
Geotropism
Force of
gravity
Region
sensitive
to
stimulus
SPM Tips
Positive geotropism:
~ helps the roots to grow deeper
into the soil
~ allows the roots to grip and
support the
plant upright.
THE END