Professional Documents
Culture Documents
Our strategy
To attract the best and brightest from other
research fields and induce them to perform
research on Down syndrome
We achieve this by creating competitive funding
mechanisms to support the best science and the
best scientists at every stage of their career
We have created the following funding
mechanisms:
1. Grand Challenges Grants for Principal Investigators
2. Doctoral and Post-doctoral Fellowships
3. Undergraduate Internships
Blumenthal
Espinosa
Potter
Pharmacology
Neurology
Gardiner
Yeager
Pediatrics
Pediatrics/Bioengineering
Extramural
University of Colorado Anschutz Medical Campus
Pediatrics
Shaikh McLean
Spritz
Hickey
Pharmacology
Immunology
DeGregori
Liu
Kennedy
Perraud
Pearson
Johnson
Hansen
Sullivan
Neurology
Dermatology
DellAcqua
Bettcher
Bilousova
Porter
Integrative Physiology
Dowell
Yi
Klymkoswky
Link
Psychology
Old
Olwin
Chen
Hoeffer
Maier
Junge
Xue
Jones
Stitzel
Boulder Campus
Brianne Bettcher
Investigating the role of
inflammation in cognitive
decline and progression of
Alzheimers disease.
Charles
AA..Hoeffer,
Charles
Hoeffer,
PhD
Charles
Hoeffer,Ph.D.
Ph.D.
Anesthesia
&&Down
ee
Anesthesia
Downsyndrom
syndrom
Investigates
the
impact
of the
Te
st
th
e
id
e
a
th
a
t
ov
e
re
x
p
re
ssion
of
a
k
ey
g
e
n
ee
TeRCAN1
st theideathatgene
overexpre
ssionchromosome
of akeygen
on
on
ch
rom
osom
e
21,
p
rom
ote
s
th
e
d
ev
e
lop
m
e
n
ttofof
onchromosome21, promotes thedevelopmen
AA
lzh
ee
im
ein
rs
ise
aa
se
-re
lala
tete
ddnn
ee
uu
rop
aa
th
ology
21
development
lzh
im
e
rsdthe
d
ise
se
-re
rop
th
ologyof
Alzheimers disease-related
neuropathology
These research projects have the potential to reveal novel approaches for
early detection and treatment of Alzheimers disease.
Ken
aclean, Ph.D.
Ken
Maclean,
PhD
KenM
Maclean,
Ph.D.
Cognition
&&Down
ee cellular
Cognition
Downsyndrom
syndrom
Test
the
impact
of the
Te
ststaahh
igig
hh
lylysp
ee
cifi
c inhh
ibib
itor
ee
yypp
rote
ininaa
ctiv
ee
Te
sp
cifi
itorofofaakk
rote
ctiv
response
tocininunfolded
proteins
in
th
e
U
n
fold
e
d
Prote
R
e
sp
on
se
a
s
a
p
ote
n
tia
l
intheUnfoldedProteinResponseas apotential
caused
by
trisomy
th
ee
ra
pp
ee
uu
tic
rg
ee
ttfor
cog
nn
itiv
eedd
ee
fi21
cits
th
ra
tictata
rg
for
cog
itiv
fi
cits on
All these research projects aim to identify molecular and cellular mechanisms
important for cognition.
Chris Porter, MD
Investigates changes in the
types and numbers of
different immune cells in
Down syndrome
These research projects could illuminate new ways to diagnose and treat autoimmune
disorders in people with Down syndrome.
William
ld,
WilliamOOOld,
PhD
William
ld,Ph.D.
Ph.D.
Protein
Expression
&&Down
ee
Protein
Expression
Downsyndrom
syndrom
Employs
proteomics
technology
SS
tutu
dd
yygg
ee
nn
ee
ssww
ith
lte
re
ddpp
rote
ininee
xp
re
ssio
ntotodd
ev
ee
lop
ithaa
lte
re
rote
xp
re
ssion
ev
lop
to
investigate
changes
in
protein
nn
ew
th
e
ra
p
e
u
tic
stra
teg
ie
s
to
a
lle
v
ia
te
issu
e
s
w
ith
ewtherapeuticstrategies toalleviateissues with
expression
by
trisomy
nn
ee
uu
rod
ev
ee
lop
m
ee
nn
ttaa
nn
dcaused
ee
uu
rod
ee
gg
ee
nn
ee
ra
tiv
ee
pp
aa
tholog
ieie
ss 21
rod
ev
lop
m
dnn
rod
ra
tiv
tholog
in stem cells
The goal of these projects is not only to reveal why there is an increased risk of leukemia
and decreased risk of solid tumors, but also to identify and test gentler,
non-toxic therapies.
Changwei
Liu,
Ph.D.
Changwei
Liu,
PhD
Changwei
Liu,
Ph.D.
Protein
Expression
syndrom
ee
Protein
Expression&
&Down
Down
syndrom
Investigates
the
gene
USP16
SS
tu
dy
eeee
ffe
ctctofofUU
SS
P16
ee
re
xp
re
ssion
on
tu
dyth
th
ffe
P16ov
ov
re
xp
re
ssion
onaa as
on
chromosome
21,
which
lala
rg
eenn
uu
m
bb
ee
rrofofoth
ee
rrce
llu
lala
rrpp
rote
inin
sstotodd
ee
tete
rm
inin
ee
rg
m
oth
ce
llu
rote
rm
known
epigenetic
regulator
ww
hh
ee
th
e
r
U
S
P16
m
ay
b
e
k
ey
to
m
a
ny
p
h
e
n
oty
p
e
s
ther USP16 maybekeyto manyphenotypes
The goal of these projects is to gain better mechanistic understanding of how trisomy 21
affects cellular and organismal behavior at the molecular level,
with the potential for far reaching impacts in the clinic.
Future Directions
1. To continue to support strong basic science on all
aspects of Down syndrome
2. To translate key findings made by our scientists into
novel diagnostics and therapeutic applications
3. To develop alliances with government and private
agencies to develop precision medicine approaches
for Down syndrome
4. To increase our educational and outreach missions
and help disseminate the results of the latest
research among the community.