TB is the leading killer of people with HIV / AIDS. Every year TB kills around 2 million people and 9 million develop the disease. Urgent need for a range of new diagnostic tools for various test indications.
TB is the leading killer of people with HIV / AIDS. Every year TB kills around 2 million people and 9 million develop the disease. Urgent need for a range of new diagnostic tools for various test indications.
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TB is the leading killer of people with HIV / AIDS. Every year TB kills around 2 million people and 9 million develop the disease. Urgent need for a range of new diagnostic tools for various test indications.
Copyright:
Attribution Non-Commercial (BY-NC)
Available Formats
Download as PPT, PDF, TXT or read online from Scribd
Workshop on Medical innovation prizes as a mechanism
to promote innovation and access
Prize for TB low-cost point of
care rapid diagnostic test Pierre Chirac
Médecins Sans Frontières, Paris, France
Campaign for Access to Essential Medicines TB : a global threat... for poor people • The most frequent infectious disease worlwide • Strong link with poverty • Mycobacterium tuberculosis usually affects the lungs but not only • Active pulmonary smear positive TB very infectious • All form of TB are deadly if lefted untreated TB : one of the big killers with AIDS and malaria • Every year TB kills around 2 million people and 9 million develop the disease
• TB is the leading killer of people with HIV/AIDS
• Almost half a million new cases of multi-drug
resistance (MDR) TB are seen every year
• Cases of extensively drug-resistant (XDR) TB are
increasingly being detected (global threat) TB : a neglected disease
• Inadequacy of tools to diagnose and treat
TB • Inadequate pipeline for the future • Lack of basic biological understanding TB : a neglected disease (2)
• Lack of funding and capacity as well as regulatory
barriers • Treatment of TB should be dramatically shortened and simplified TB : a neglected disease (3)
• Strong link TB/HIV
• Dramatic surge of multi-drug resistant TB (MDR-TB) • Urgent need for a range of new diagnostic tools for various test indications MSF and TB
• In areas of chronic conflict or politically
instable contexts
• In 2006, around 29,000 patients in 40
countries around the world. MSF and TB (2)
• Growing number of patients infected with
MDR-TB • Rapid spread of TB among people living with HIV/AIDS. • Lack of reliable, rapid ways to diagnose TB TB diagnostic
• Microscope cheap but only detects around
half of all TB cases • Culture too slow • Improvements to culture remain logistically difficult • More modern methods are too sophisticated TB diagnostic (2) • In MDR-TB, further tests are necessary • Drug resistance can be more rapidly detected by new molecular tests but can’t be done in the remote areas TB and R&D needs
• New diagnostic tools that are simple, reliable, and
adapted for use in remote, resource-poor settings • More potent drugs to shorten the length of treatment • Drugs that do not negatively interact with AIDS drugs • Effective vaccine to protect against the disease MSF assessment of pipeline
• Huge resource gap in TB R&D
• Governments and public agencies must take a leadership role • IGWG could provide the necessary framework for action • Scientists, doctors, public health specialists, laboratory technicians, and FIND should share information and resources • Field needs should guide product development • MSF NY
• The TB community must engage in the
IGWG process • participants of the New York symposium support current discussion at the WHO for a treaty on essential health R&D MSF NY Participants call upon governments, intergovernmental agencies, researchers, drug and diagnostic developers, nongovernmental organizations, and funders to take action in five key areas. • 3. Support new approaches to R&D • 4. Commit to global TB R&D leadership • 5. Increase funding for TB R&D activities MSF and TB next
• Promote an open source/open access model
innovation for TB and neglected diseases: a) case study on how to stimulate and fund TB drugs and diagnostics R&D b) feed outcomes of the expert meeting into the IGWG TB diagnostic test : a good case for a prize • Many examples of prizes that have been offered to stimulate or recognize research, treatment, prevention and care of tuberculosis from 1887 to 2007 • InnoCentive Tuberculosis Prize for PA-824 (2007) for a “Safe and Economical Synthetic Route for PA-824, a candidate drug for tuberculosis.” Funded by the Rockefeller Foundation ($20,000) • low-cost point of care rapid diagnostic test : the next TB prize ?