General Pathology

Lab 5
2015.09.06
Cyrus Crystan D. Georsua

Signet-ring Cell: palelooking cells with

hyperchromatic nucleus at
one point of the cells
periphery

N:C ratio is
almost 1:8

Signet-ring
Cell
Signet-ring
Cell

Signet-ring
Cell

In a normal cervix, the

squamo-columnar junction
is distinct

In an injured
cervix,
metaplasia
from simple
columnar to
stratified
squamous is
normal

Endocervix =
lined by simple
columnar
epithelium
Ectocervix =
lined by
stratified

Simple Columnar
Epithelium
Squamo-columnar
Junction
Stratified Squamous NonKeratinizing Epithelium

HSIL
because
there is:
(1)Nuclear
atypia:
nucleus
of the
tissue is
not
aligned
with the
basement
membran
e

Dysplastic
Tissue

Basement
Membrane

Mitotic
Figures
are not an
indicator
of
malignanc
y because
tissues
with high
turn-over
rate have
high
mitotic
figures

Normal Mitotic
Figures are
Bipolar

Bizarre Mitotic
Figure

Normal Mitotic
Figure

Normal Mitotic
Figure
Normal Mitotic
Figure
Normal Mitotic
Figure

Cells
undergoing
metaphase
and
anaphase
have 2
purple
condensation
s in 1 cell

Normal Mitotic
Figures are
Bipolar

Mitotic Figures are not

an indicator of
malignancy because
tissues with high turnover rate have high
mitotic figures

Bizarre Mitotic
Figure

Cells undergoing
metaphase and
anaphase have 2
purple condensations
in 1 cell (which are

In a normal
tissue, fibers
grow in an
ordered
fashion.

Swirl
Pattern

Unlike the
herringbone
pattern in
Fibrosarco
ma, the
swirl pattern
in Fibroma
has no
definite
straight line.
Swirl Pattern

In a normal
tissue, fibers
grow in an
ordered
fashion.

Herringbo
ne Pattern

Herringbone
Pattern

Herringbone
Pattern

Unlike the
swirl
pattern in
Fibroma,
the
herringbon
e pattern in
Fibrosarco
ma has a
definite
straight
line.

In a normal
tissue, fibers
grow in an
ordered
fashion.

Herringbo
ne Pattern

Herringbone
Pattern

Unlike the
swirl
pattern in
Fibroma,
the
herringbon
e pattern in
Fibrosarco
ma has a
definite
straight
line.

Lipoma is a
benign
tumor that
microscopic
ally looks
like adipose
tissue
undergoing
hyperplasi
a
Looks like a
regular
adipocyte
with very
clear
cytoplasm
and a small
nucleus
pushed to
the
periphery

Adipocyte

Adipocyte

Liposarcoma
is a
malignant
tumor that
microscopic
ally looks
like adipose
tissue
undergoing
hyperplasi
a
Looks like a
different
adipocyte
with very
clear
cytoplasm
and a
prominent,
hyperchrom
atic nucleus

Adipocyte

Adipocyte

Looks like
capillaries
undergoing
hyperplasi
a

Capillaries
because the
vessel is (1)
small, and

Capillary
Hemangioma

Thyroid
Gland,
histologicall
y, has
Follicles
(the red
thing)
surrounded
by
Follicular
Cells
Follicular
Adenoma
because
there is
dysplastic
growth of
follicular
Cancer because
cells, and no
there is (1) few
capsular
and (2) small
invasion aka
follicles, and (3)
the capsule
there is
is still intact
dysplastic

Follicles

Capsule

Dysplastic
Follicular Cell
Growth

Thyroid
Gland,
histologicall
y, has
Follicles
(the red
thing)
surrounded
by
Follicular
Cells

Follicular
Adenocarcino
ma because
there is
dysplastic
growth of
follicular
cells, and
there is

Capsule

Dysplastic
Follicular Cell
Growth

Capsular
Invasion
Dysplastic
Follicular Cell
Growth

Capsule

Cancer
because
there is
(1) few
and (2)
small
follicles,
and (3)
there is
dysplasti
c growth
of

Polyps are
outgrowth
tissues
from the
normal
tissue

Polyp

Back-to-back
Glands

Hyperplastic
because there is
increased gland to
stroma ratio which
makes the gland

Back-toback
Glands

ModeratelyDifferentiate
d
Adenocarcino
ma because
(1) the
pattern of
the normal
intestinal
gland is still
appreciated
in the tumor,
albeit they
are small, (2)
they are
numerous in
number
compared to
normal, and
(3) they are
small in size
compared to
normal.

ModeratelyDifferentiated
Colonic
Adenocarcinoma

Normal
Intestinal
Glands

PoorlyDifferentiat
ed
Adenocarcin
oma
because (1)
the pattern
of the
normal
intestinal
gland is still
appreciated
, albeit they
are small,
(2) they are
numerous
in number
compared
to normal,
and (3) they
are small in
size
compared
to normal.

PoorlyDifferentiated
Adenocarcinoma

ModeratelyDifferentiated
Adenocarcinoma

The mere
presence of
signet-ring
cells is
indicative of
Poorlydifferentiate
d
Adenocarcin
oma
Signet-ring
Cells are
tumor cells
that are
mucin-filled
and the
nucleus
pushed to the
periphery of
the cell

Signet-ring Cell

Signet-ring Cell

Signet-ring Cell

Fibroadeno
ma is a
benign
tumor of
the breasts
At gross,
the lesion is
palpable,
wellcircumscrib
ed, and
movable

Slit-like Ducts
Myxohyaline
Stroma

Myxohyal
ine
Stroma
Slit-like Ducts

Invasive
Ductal
Carcinoma
is a
malignant
tumor of
the breasts
At gross,
the lesion is
hardly
palpable,
poorlycircumscrib
ed, and
hardly
movable
Unlike
Ductal
Carcinoma
In Situ
(DCIS), the
tumor cells

Tumor Cells
Capsule

Capsular
Invasion

Squamous
Papilloma is
a benignlooking tumor
Papilloma
because it is
an outgrowth
* From the
keyword
papilla (aka
tongue)
Squamous
because,
histologically,
it is lined by
squamous
cells

Papilloma
Squamous Cells

Invasive
Squamous Cell
Carcinoma is a
malignant tumor
found most of the
time at the cervix
Invasive because it
has breached the
basement
membrane
cannot be seen
because there is
dysplastic growth
everywhere and
perhaps most of
the basement
membrane have
been obliterated
Grade 1
Keratinizing
because of keratin
pearls which are

Dysplastic
Growth
EVERWHERE!
Keratin Pearls

Mixed Tumor
because you
see structures
that normally
dont belong in
that particular
tissue

Adipocytes
Skin
In a normal
parotid gland,
you only see
salivary glands
and capsule
Skin is
epithelial in
origin
Adipocytes and
Fibroblasts are

Collagen
Fiber from
Fibroblasts

Normal
Salivary
Gland
Capsule

Teratoma because you

see components coming
from the 3 germ lines:
1) Ectoderm = skin and
neural elements
2) Mesoderm = muscle,
and connective tissue
3) Endoderm = visceral
Sebaceous
structures
Glands

Hair Follicle
Cartilage
Sebaceous
Glands
Adipocytes
You dont normally
see these in an

Neuroendocrine
Elements