CAMPBELL

BIOLOGY

TENTH
EDITION

Reece Urry Cain Wasserman Minorsky Jackson

1
Evolution, the
Themes of Biology,
and Scientific Inquiry
Lecture Presentation by
Nicole Tunbridge and
Kathleen Fitzpatrick
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Inquiring About Life

Nothing in biology makes sense except in the light
of evolutionTheodosius Dobzhansky
Evolution is the process of change that has
transformed life on Earth

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 Biology is the scientific study of life

Biologists ask questions such as
How does a single cell develop into an organism?
How does the human mind work?

Life defies a simple, one-sentence definition

*Brainstorm: How can you test if

something is alive?

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Figure 1.2 Some properties of life

Order

Regulation
Evolutionary
adaptation

Energy processing

Growth and
development
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Response
to the
environment

Reproduction

Concept 1.1: The study of life reveals common

themes
There are five unifying themes
1. Organization
2. Information
3. Energy and matter
4. Interactions
5. Evolution

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Video: Seahorse Camouflage

Theme 1: New Properties Emerge at Successive

Levels of Biological Organization
Life can be studied at different levels, from
molecules to the entire living planet
This enormous range can be divided into different
levels of biological organization

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Figure 1.3 Exploringlevelsofbiologicalorganization

7 Tissues

1 The Biosphere
6 Organs
and Organ
Systems

2
Ecosystems

10
Molecules

3
Communities

8
Cells

5
Organisms

9 Organelles
4 Populations
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Biological organization: hierarchy of life

_
_
_
_

The entire portion of Earth inhabited by life

_
_

Two or more atoms held together by covalent bonds

_
_
_
_

The specialized structures within a cell that perform a specific function

The smallest structural and functional unit of an organism

An interacting group of various species in a common location
The complex of living organisms, their physical environment, and all
their interrelationships in a particular location
A group of tissues in a living organism that have been adapted to
perform a specific function
An individual living thing
A group of individuals of the same species that live in the same location
A group of structurally and functionally similar cells and their
intercellular material

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Emergent Properties
Emergent properties result from the arrangement
and interaction of parts within a system
Example: bicycle

Reductionism is the reduction of complex systems

to simpler components that are more manageable
to study
Example: studying the molecular structure of DNA
helps us to understand the chemical basis of
inheritance

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Systems Biology
A system is a combination of components that
function together
Systems biology constructs models for the
dynamic behavior of whole biological systems
How does a drug for blood pressure affect other
organs?
How does increasing CO2 alter the biosphere?

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Structure and Function

At each level of the biological hierarchy we find a
correlation between structure and function

Form fits function in a gulls wing: wings, bones, neurons,

and infoldings of membranes in mitochondria
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The Cell: An Organisms Basic Unit of Structure

and Function
The cell is the lowest level of organization that can
perform all activities required for life
All cells
Are enclosed by a membrane
Use DNA as their genetic information

A eukaryotic cell has membrane-enclosed

organelles, the largest of which is usually the nucleus
By comparison, a prokaryotic cell is simpler and
usually smaller, and does not contain a nucleus or
other membrane-enclosed organelles
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Figure 1.4 Contrastingeukaryoticandprokaryoticcellsinsizeandcomplexity

Eukaryotic cell
Membrane

Prokaryotic cell
DNA
(no nucleus)
Membrane

Cytoplasm

Nucleus
(membraneenclosed)
Membraneenclosed organelles
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DNA (throughout
nucleus)

1 m

Theme 2: Lifes Processes Involve the Expression

and Transmission of Genetic Information
Within cells, structures called chromosomes
contain genetic material in the form of DNA
(deoxyribonucleic acid)
25 m

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DNA, the Genetic Material

Each chromosome has one long DNA molecule
with hundreds or thousands of genes
Genes encode information for building the
molecules synthesized within the cell
Genes are the units of inheritance
The ability of cells to divide is the basis of all
reproduction, growth, and repair of multicellular
organisms

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Figure 1.6 InheritedDNAdirectsdevelopmentofanorganism

Nuclei containing DNA

Sperm cell

Egg cell

Fertilized egg
with DNA from
both parents

Embryos cells
with copies of
inherited DNA
Offspring with
traits inherited
from both parents

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Figure 1.7 DNA:Thegeneticmaterial

Nucleus

DNA

Nucleotide

T
A

Cell

T
A
C
C
G
T
A
G
T
A
(a) DNA double helix

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(b) Single strand of DNA

Figure 1.8 Geneexpression

(b) How do lens cells make crystallin proteins?

Crystallin gene

(a) Lens cells are

tightly packed
with transparent
proteins called
crystallin.

Lens
cell
DNA

A C

G A

G G

G C

G G

U G

G C

TRANSCRIPTION

Genes control protein

production indirectly
DNA is transcribed into
RNA, which is then
translated into a protein
Gene expression is the
process of converting
information from gene to
cellular product
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mRNA
TRANSLATION
Chain of amino
acids

PROTEIN FOLDING

Protein
Crystallin protein

Genomics: Large-Scale Analysis of DNA

Sequences
An organisms genome is its entire set of genetic
instructions
The human genome and those of many other
organisms have been sequenced
Genomics is the study of sets of genes within and
between species
Proteomics is the study of whole sets of proteins
encoded by the genome (known as proteomes)

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 The genomics approach depends on

High-throughput technology, which yields
enormous amounts of data
Bioinformatics, which is the use of computational
tools to process a large volume of data
Interdisciplinary research teams

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Theme 3: Life Requires the Transfer and

Transformation of Energy and Matter
The input of energy from the sun and the
transformation of energy from one form to another
make life possible
The dynamics of an ecosystem include two
major processes:
The flow of energy
Cycling of nutrients

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Figure 1.9 Energyflowandchemicalcycling

ENERGY FLOW
Chemicals
pass to
organisms
that eat the
plants.

Light
energy

Chemical
energy

Heat

Plants take
up chemicals
from the soil
and air.
Chemicals

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Decomposers
return
chemicals
to the soil.

Theme 4: From Ecosystems to

Molecules, Interactions Are
Important in Biological Systems
Interactions between the components of the
system ensure smooth integration of all the parts
This holds true equally well for components of an
ecosystem and the molecules in a cell
Each organism interacts continuously with other
organisms
These interactions may be beneficial or harmful to
one or both of the organisms
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gure 1.10 InteractionsofanAfricanacaciatreewithotherorganismsandthephysicalenvironment

Sunlight
Leaves absorb light
energy from the sun.

CO2 Leaves take in

carbon dioxide
from the air and
release oxygen.
O2

Leaves fall to the

ground and are
decomposed by
organisms that
return minerals
to the soil.
Water and
minerals in
the soil are
taken up
by the tree
through its
roots.
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Animals eat leaves

and fruit from the tree,
returning nutrients
and minerals to the
soil in their waste
products.

Molecules: Interactions Within Organisms

Interactions between componentsorgans,
tissues, cells, and moleculesthat make up living
organisms are crucial to their smooth operation
Cells are able to coordinate various chemical
pathways through a mechanism called feedback
In feedback regulation the output, or product of a
process, regulates that very process
Feedback is a regulatory motif common to life at all
levels
The most common form of regulation in living
organisms is negative feedback, in which the
response reduces the initial stimulus
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Figure 1.11 Feedbackregulation

STIMULUS: High
blood glucose level

Negative feedback

Insulin-producing
cell in pancreas
Insulin
Circulation
throughout
body via
blood

Liver and
muscle cells

RESPONSE: Glucose
uptake by liver and
muscle cells
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Evolution, the Core Theme of Biology

Evolution is the one idea that makes
logical sense of everything we know
about living organisms
The scientific explanation for both
the unity and diversity of organisms
is the concept that living organisms
are modified descendants of
common ancestors
Many kinds of evidence support the
occurrence of evolution
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Concept 1.2: The Core Theme: Evolution

accounts for the unity and diversity of life
Evolutionary mechanisms account for the unity
and diversity of all species on Earth

Think-pair-share:
*How many species have been
identified and named?
*How many species actually
exist?

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Classifying the Diversity of Life

Approximately ____ _illion species have been
identified and named to date, and thousands more
are identified each year
Estimates of the total number of species that
actually exist range from ___ _illion to over ___
_illion

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Grouping Species: The Basic Idea

Taxonomy is the
branch of biology
that names and
classifies species
into groups of
increasing breadth
Domains, followed
by kingdoms, are the
broadest units of
classification

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Figure 1.12 Classifyinglife

Ursus americanus
SPECIES

GENUS FAMILY

ORDER

CLASS PHYLUM KINGDOM DOMAIN

Ursus

Ursidae

Carnivora

Mammalia

Chordata

Animalia

Eukarya
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The Three Domains of Life

Organisms are divided into three domains, named
Bacteria, Archaea, and Eukarya
Domain Bacteria and domain Archaea compose
the prokaryotes (single-celled, simple, small, etc.)

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2 m

(b) Domain Archaea

2 m

(a) Domain Bacteria

 Domain Eukarya includes all

eukaryotic organisms
Domain Eukarya includes three
multicellular kingdoms
Plants, which produce their own food
by photosynthesis
Fungi, which absorb nutrients
Animals, which ingest their food
Protists are generally divided into a
number of supergroups
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Unity in the Diversity of Life

A striking unity underlies the diversity of life; for
example
DNA is the universal genetic language common to
all organisms
Unity is evident in many features of cell structure

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Figure 1.14 Anexampleofunityunderlyingthediversityoflife:thearchitectureofciliaineukaryotes

5 m

Cross section
of a cilium
15 m

Cilia of
Paramecium

Cilia of
windpipe cells

0.1 m

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Charles Darwin and the Theory of

Natural Selection
Fossils and other evidence document the
evolution of life on Earth over billions of years
Charles Darwin published On the Origin of
Species by Means of Natural Selection in
1859
Darwin made two main points
Species showed evidence of descent
with modification from common
ancestors; natural selection is the
mechanism
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 Darwin observed that

Individuals in a population vary in their traits, many
of which are heritable
More offspring are produced than survive, and
competition is inevitable
Species generally suit their environment

Darwin inferred that

Individuals that are best suited to their environment
are more likely to survive and reproduce
Over time, more individuals in a population will
have the advantageous traits

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 Evolution occurs as the unequal reproductive

success of individuals
In other words, the environment selects for the
propagation of beneficial traits
Darwin called this process natural selection
Natural selection results in the adaptation of
organisms to their environment
Darwins theory explained the duality of unity and
diversity

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Figure 1.17 Unityanddiversityamongbirds

European robin

American flamingo

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Gentoo penguin

Figure 1.18 Naturalselection

1 Population

with varied
inherited
traits

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2 Elimination

of individuals
with certain
traits

3 Reproduction

of survivors

4 Increasing

frequency
of traits that
enhance
survival

The Tree of Life

Unity in diversity arises from descent with
modification
For example, the forelimb of the bat, human, and
horse and the whale flipper all share a common
skeletal architecture

Fossils provide additional evidence of anatomical

unity from descent with modification

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Insect-eaters

Green warbler finch

Certhidea olivacea
Gray warbler finch
Certhidea fusca

Bud-eater

Seed-eater

COMMON
ANCESTOR

Warbler finches

Figure 1.20 Descent with modification: adaptive radiation of finches on the Galpagos Islands.

Sharp-beaked
ground finch
Geospiza difficilis
Vegetarian finch
Platyspiza crassirostris
Mangrove finch
Cactospiza heliobates

Insect-eaters

Tree finches

Woodpecker finch
Cactospiza pallida
Medium tree finch
Camarhynchus pauper
Large tree finch
Camarhynchus psittacula
Small tree finch
Camarhynchus parvulus

Seed-eaters

Ground finches

Darwin proposed that

natural selection could
cause an ancestral
species to give rise to two
or more descendent
species
For example, the
finch species of the
Galpagos Islands
are descended from
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a common ancestor

Cactus-flowereaters

Large cactus
ground finch
Geospiza conirostris
Cactus ground finch
Geospiza scandens
Small ground finch
Geospiza fuliginosa
Medium ground finch
Geospiza fortis
Large ground finch
Geospiza
magnirostris

Concept 1.3: In studying nature, scientists make

observations and form and test hypotheses
The word science is derived from Latin and
means to know
Inquiry is the search for information and
explanations of natural phenomena
The scientific process includes making
observations, forming logical hypotheses, and
testing them

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Making Observations
Recorded observations are
called data
Qualitative data often take the
form of recorded descriptions
For example, Jane Goodalls
observations of chimpanzee
behavior

Quantitative data are generally

expressed as numerical
measurement, organized into
tables and graphs

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Inductive Reasoning
Inductive reasoning draws conclusions through
the logical process of induction
Repeat specific observations can lead to
important generalizations
For example, the sun always rises in the east
Observations and inductive reasoning can lead
us to ask questions and propose hypothetical
explanations called hypotheses

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Forming and Testing Hypotheses

In science a hypothesis is a tentative answer to a
well-framed scientific question
It is usually a rational accounting for a set of
observations
It leads to predictions that can be tested by
making additional observations or by performing
experiments

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Figure 1.22 A campground example of

hypothesis-based inquiry.

For example
Observations

Observation: Your flashlight doesnt

work
Question: Why doesnt your
flashlight work?
Hypothesis 1: The batteries are
dead
Hypothesis 2: The bulb is burnt out

Question

Hypothesis #1:
Dead batteries

Hypothesis #2:
Burnt-out bulb

Prediction:
Replacing batteries
will fix problem

Prediction:
Replacing bulb
will fix problem

Test of prediction

Test of prediction

Test falsifies hypothesis

Test does not falsify hypothesis

Both these hypotheses are testable

Support (or lack of contradiction) of
a hypothesis does not prove that
hypothesis

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Questions That Can and Cannot Be Addressed

by Science
A hypothesis must be testable and falsifiable
For example, a hypothesis that ghosts broke the
flashlight cannot be tested

Supernatural and religious explanations are

outside the bounds of science

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Deductive Reasoning
Deductive reasoning uses general premises to
make specific predictions
Initial observations may give rise to multiple
hypotheses
In the scientific process, deductive testing takes the
form of Ifthen logic.
We can never prove that a hypothesis is true, but
testing it in many ways with different sorts of data
can increase our confidence in it tremendously

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The Flexibility of the Scientific Process

The scientific method is an idealized process of
inquiry
Hypothesis-based science is based on the
textbook scientific method but rarely follows all
the ordered steps
Backtracking and rethinking may be necessary
part way through the process

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Experimental Variables and Controls

In a controlled experiment, an experimental
group is compared with a control group
Ideally experimental and control groups differ in
only the one factor under investigation
Without controls the researchers would not be
able to rule out other factors besides model color
that might have affected the results

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Theories in Science
In the context of science, a theory is
Broader in scope than a hypothesis
General, and can lead to new testable
hypotheses
Supported by a large body of evidence in
comparison to a hypothesis
A scientific theory is a well-substantiated
explanation of some aspect of the natural world
that is acquired through the scientific method, and
repeatedly confirmed through observation and
experimentation.
National Academy of Sciences and AAAS Evolution Resources
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Science, Technology, and Society

The goal of science is to understand natural
phenomena
The goal of technology is to apply scientific
knowledge for some specific purpose
Science and technology are interdependent

DNA tests exonerate the innocent

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You should now be able to:

Briefly describe the unifying themes that
characterize the biological sciences
Describe the levels of the hierarchy of biological
organization
Distinguish among the three domains of life, and
the eukaryotic kingdoms
Describe the scientific methods

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