Professional Documents
Culture Documents
By Marissa Grotzke
The Testes
Paired, ovoid organs
Dual functions
1. Production of sperm
Testosterone
Spermatic cord can retract testicles into inguinal canal when injury is
threatened.
Spermatogenesis
Spermatogonia: stem cells that form sperm
Spermatogonia undergo mitosis & miosis; haploid cells
transform to form mature sperm.
Mature sperm has head, body, & tail so it can swim.
Hormonogenesis
Testosterone: controlled by FSH & LH, which are produced
by gonadotrophs
Hypergonadotropic hypogonadism
Klinefelters syndrome
Testicular feminization syndrome
5-alpha-reductase deficiency
Myotonic dystrophy
Testicular injury and infection
Sertoli-cell-only syndrome
Hypogonadotropic hypogonadism
Kallmanns syndrome
Hyperprolactinemia
Age
Pituitary disease
Parenteral testosterone
Intramuscular injection; most widely available & cost-effective
Testosterone gel
Gel applied to nongenital skin; risk of transmission to others
Buccal testosterone
Plastic tablet placed along gum line; local discomfort
Routine clinical evaluation for leg edema, sleep apnea, & prostate
enlargement
The Ovary
Paired organs with dual functions
Others
Inhibins A & B inhibit FSH production; activin enhances FSH
secretion & induces steroidogenesis.
Folliculostatin, relaxin, follicle regulatory protein, oocyte
maturation factor, meiosis-inducing substance
Follicular phase
Begins with onset of menses & ends on day of LH surge
A rise in FSH stimulates estrogen production.
Luteal phase
Starts with extrusion of ovum, about 36 hours after LH surge
Ends with onset of menses
Central control of FSH & LH secretion resides in gonadotropinreleasing hormone (GnRH) pulse generator of arcuate nuclei &
medial preoptic nuclei of hypothalamus.
Hypogonadotropic hypogonadism
Deficiency of FSH & LH; can cause secondary amenorrhea
Hypergonadotropic hypogonadism
Ovarian failure with elevation of FSH concentrations